Search Results

You are looking at 1 - 10 of 40 items for :

  • "human heart" x
  • Refine by Access: All Content x
Clear All
Acta Physiologica Hungarica
Authors:
J Dudka
,
F Burda
,
Barbara Madej
,
Justyna Szumilo
,
Edyta Tokarska
,
Agnieszka Korobowicz
,
R Klepacz
,
Monika ChyüyÅska
, and
Elżbieta Korobowicz

Metabolic acidosis complicates methanol, ethylene glycol and other alcohol intoxications. It is caused firstly by acid metabolites and secondly by the lactate elevation. The aim of the study was to evaluate the effect of alcohol dehydrogenase (ADH; EC 1.1.1.1) inhibitors and substrates: 4-methylpyrazole (4-MP), cimetidine, EDTA, ethanol and methanol on lactate dehydrogenase (LDH; EC 1.1.1.27) activity. The activity of LDH was determined spectrophotometrically in in vitro human heart homogenates with the mentioned compounds at 0.01, 0.1, 1.0 mM concentrations of 4-MP, cimetidine, EDTA, and 12.5, 25.0, 50.0 mM of ethanol and methanol. The LDH activity was significantly inhibited by 0.1 mM (p<0.05) and 1.0 mM (p<0.01) 4-MP and 1.00 mM EDTA (p<0.05). Higher LDH activity vs. control was observed in the samples incubated with all studied ethanol and methanol concentrations but these differences were not statistically significant. Thus, 4-MP was found to be the most effective inhibitor of LDH of all compounds tested. Therefore, such effect of 4-MP seems to be an additional advantage in methanol and ethylene glycol intoxications.

Restricted access

.: Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev., 1999, 51 (4), 651–690. 51 La Rovere, M. T., Specchia, G., Mortara, A., et al.: Baroreflex

Restricted access

This article compares Euripides’s Iphigenia Taurica with Goethe’s Iphigenie auf Tauris, and investigates how the theme of love between siblings is related to the religious issue in both tragedies. I firstly analyze how, in the Euripidean tragedy, the value of familial love can connect the two worlds of gods and humans, thanks to the parallel between the human (Iphigenia and Orestes) and the divine couple of siblings (Artemis and Apollo). By sharing this human value, the gods demonstrate that they can be different from the immoral deities depicted in myth, and correspond to Iphigenia’s ethically purified image of them. However, the Euripidean plot included at least three elements which an Eighteenth-century intellectual could not accept (paragraph three): the obscurity of the divine messages; the centrality of theft and cunning; the inability of men to solve the tragic predicament autonomously. The value of family affection is momentous for the removal of those elements (paragraph four): in the Goethean play, the Gods demonstrate that they share it not by directly intervening, but by providing the human sister with the powers of the divine sister: therefore, Iphigenia can heal her brother, and the statue of Artemis need not to be stolen. Iphigenia proves that the gods speak to the human heart, and in this way the problem of communication with the supernatural sphere is solved.

Restricted access
Interventional Medicine and Applied Science
Authors:
Tamás Ruttkay
,
László Bárány
,
András Grimm
,
Lajos Patonay
,
Örs Petneházy
,
Gergely Rácz
,
Gábor Baksa
, and
Zoltán Galajda

Introduction

Many coronary anastomotic devices have been designed to replace manual stitching in coronary surgery; however, interestingly, none of them became widespread. Our aim was to work out an easy and fast endoluminal vessel-to-vessel stent bridge distal anastomotic technique.

Materials and methods

Ten coronary arteries of eight fresh human hearts were used in this study. The anastomosis was performed with the implantation of a graft vessel into the lumen of the coronary artery by performing stent fixation. The technique is described and photo documented in detail. The durability and the conductibility of the anastomosis were examined with intraluminal endoscopy, functional streaming test, and a coloring of the vessels.

Results

The anastomosis had great results in all cases. Obstruction, dissection, or dislocation of the vessels was not observable.

Conclusions

This study confirmed the ex-vivo feasibility of the described technique. This method can be an easy, fast, and reliable method applied in the endoscopic distal coronary artery anastomosis surgery. The development of stents adapted to this method and the in-vivo testing of this technique are necessary for the future.

Open access

A meszes mitralis billentyű sebészi kimetszése ultrahangvágóval

Excision of the calcified mitral valve with ultracision knife

Magyar Sebészet
Authors:
Dashti Asghar
,
Lehel Palotás
,
Zsanett Kromplák
,
Lajos Patonay
,
István Szentkirályi
, and
Zoltán Galajda

Absztrakt

Jelenleg az elmeszesedett mitralis billentyű kimetszése ultrahangvágóval még nem meghonosodott eljárás a szívsebészetben. A szerzők az elmeszesedett mitralis billentyű kimetszését ultrahangvágóval végezték, ily módon lerövidítve a műtét idejét. Ugyanakkor a billentyű kimetszése helyben történik, anélkül hogy előhúznák vagy kiemelnék. Az eljárást előbb sertésszíveken (20 eset) próbálták ki, majd 15 emberen végzett műtét során alkalmazták. A kísérletekben és műtéteknél nyert szövetmintákat szövettani vizsgálatnak vetették alá. A szöveti károsodás átlagos kiterjedése az állatkísérleteknél 0,7 mm-t, az emberi műtétek esetén 1,1 mm-t mutatott. Nem észleltek hátrányos mellékhatást az ultrahangvágó használatával mitralis billentyű kimetszése során, és ezért javasolják a használatát.

Restricted access

References 1 Durrer D, van Dam RT, Freud GE, et al. Total excitation of the isolated human heart. Circulation 1970; 41: 899

Restricted access

Durrer, D., van Dam, R. T., Freud, G. E., et al.: Total excitation of the isolated human heart. Circulation, 1970, 41 , 899–912. Freud G. E. Total excitation of the isolated human

Open access
Orvosi Hetilap
Authors:
László Balogh
,
István Czuriga
,
János Hunyadi
,
László Galuska
,
Éva Kristóf
, and
István Édes

Strauer, B. E., Brehm, M., Zeus, T. és mtsai Regeneration of human heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease. The ICAT Study. J. Am. Coll. Cardiol., 2005, 46 , 1651

Restricted access
Orvosi Hetilap
Authors:
Réka Urbancsek
,
Ildikó Noémi Forgács
,
Tímea Bianka Papp
,
Judit Boczán
,
Judit Barta
,
István Édes
,
Zoltán Csanádi
, and
László Rudas

Kaye DM, Lefkovits J, Jennings GL, et al. Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol. 1995; 26: 1257

Open access
Orvosi Hetilap
Authors:
Tamás Szili-Török
,
Csaba Földesi
,
Berthold Stegeman
,
Zsolt Török
,
Éva Sitkei
,
Tamás Farkas
, and
László Rudas

1992 Elam, M., Macefield, V.: Multiple firing of single muscle vasoconstrictor neurons during cardiac dxsrrhythmias in human heart

Restricted access