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hypericin in some Hypericum species from Turkey during the course of ontogenesis. — Biochem. Syst. Ecol. 34 : 1–13. Kevseroğlu K. Morphogenetic and diurnal variation of hypericin in

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Hypericum perforatum L. (St. John's wort) is a well-known traditional medicinal plant that has been used for centuries for the treatment of several diseases and this feature is obviously attributed to the presence of a broad spectrum of secondary metabolites including hypericins. In the present study, the aim was to determine total hypericin content of this plant from wild population of Northern Turkey. Thus, Hypericum perforatum plants representing a total of 45 wild populations were collected from 15 sites in each of 3 regions, during flowering and subsequently assayed for total hypericin. Hypericin content in these wild populations varied from 0.28 to 4.46 mg/g dry matter. According to the results of analysis of variance, there was a significant difference in hypericin content between sites as well as regions. One of the problems associated with medicinal plant preparations is the extreme variability in the phytomedicinal and marker compounds. Products containing H. perforatum have varied greatly in content of secondary metabolites since it is currently supplied by cultivated and wild-harvested materials. Therefore the variation of phytomedicinals like hypericin in H. perforatum, especially from wild populations has a great importance in term of health care and herbal industry.

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Acta Botanica Hungarica
Authors: C. Çi̇rak, M. Odabaş, A. Ayan, B. Sağlam, and K. Kevseroğlu

Agostinis, P., Annelies, V., Wilfried, M. and Peter A. M. (2002): Hypericin in cancer treatment: more light on the way. — Int. J. Biocem. Cell Biol. 34 : 221

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hipericina en Hierba de San Juan ( Hypericum perforatum L.) en función del ambiente y tiempo de postcosecha. [(Hypericin content in St. John's wort ( Hypericum perforatum L.) as a function of environment and postharvest time).] Agro-Ciencia , 16 , 243

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derivatives, phenolic compounds, and essential oils ( Zhao et al., 2015 ). Among the chemical constituents, hypericin and hyperforin were indicated to be synergistically responsible for the antidepressant activity of Hypericum extracts ( Kasper et al., 2010

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., Komjatiova , M., Csanyiova , Z., Galova , E., Cellarova , E. & Vlcek , D. (2010): Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin. Phytotherapy Res ., 24 , 90–95. Vlcek D

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. , Krasnoff , S. B. and Gibson , D. M. ( 2003 ): Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores . – J. Chem. Ecol. 29 : 2667 – 2681 . https://doi.org/10.1023/b:joec.0000008011

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, P.R. China), hypericin was purchased from Chengdu Munster biotechnology company (Chengdu, China), and hyperforin was purchased from ChromaDex Corporate (California, USA). (6 S ,7 E ,9 R )-Roseoside was isolated in our laboratory (purity, >98%), and

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Hungarian Medical Journal
Authors: Yousif Asiri, Abdlatif Al-Dhawailie, Saleh Alqasoumi, Mohammed Al-Yahya, and Syed Rafatullah

De Los Leyes, G. C., Koda, R. T.: Determining hyperforin and hypericin content in eight brands of St. John’s wort. Am. J. Health Syst. Pharm., 2002, 59 , 545–7. Koda R. T

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