Authors:G. Challet-Bouju, E. Hurel, E. Thiabaud, J. Leboucher, M. Leroy, A. L. Quibel, and M. Grall-Bronnec
related to both gambling and gambling problems. These include cognitive flexibility, planning, decision making, response inhibition, learning and working memory, intellectual functioning and the capacity to adapt a strategy within the gambling environment
A new thermokinetic reduced extent method for the product inhibition of single substrate enzyme-catalyzed reactions is proposed
and compared with the traditional initial rate method in this paper. The arginase-catalyzed hydrolysis of L-arginine to L-ornithine and urea was studied at 37C in 40 mM sodium barbiturate-HCl buffer solution (pH=9.4). Michaelis constant (Km) for arginine and maximum velocity (Vm) of the reaction were determined by initial method and thermokinetic method. The activation of exogenous manganese to this
reaction was also studied. The product inhibition constant (KP), which cannot be obtained directly from the initial rate method, was determined by thermokinetic without adding L-ornithine
to the reaction system. When the concentration of Mn2+ in cell is 0.1 mM, the enzyme gets its full activity. Incubation arginase with appropriate concentration of Mn2+resulted in increased Vmax and a higher sensitivity of the enzyme to product with no change in the Km for arginine. We suggest that the exogenous manganese ions in solution have just recovered the activity of arginase, which
was lost in dissolving and dilution, but no effect on the mechanism of the reaction.
deviation. ** P < 0.01 with a one-way analysis of variance followed by Tukey's test. hc, hair cells. sgn, spiral ganglion neurons Cx43 inhibition suppresses the growth of fibers and synaptogenesis of H.C. To test the effects of Cx43 on the re-innervation of
might have problems with inhibition, but little research has been conducted on this issue. The current study attempted to address that knowledge gap.
Inhibition of interfering information is essential in order to focus attention, eliminate
Authors:G.P. Li, D. Zhou, L.N. Kan, Y.W. Wu, J.F. Fan, and J. Ouyang
De La Rosa
, L. , Alvarez-Parrilla , E. , Moyers-Montoya , E. , Villegas-Ochoa , M. , Ayala-Zavala , J. , Hernández , J. , Ruiz-Cruz , S. & González-Aguilar , G.A. ( 2011 ): Mechanism for the inhibition of apple juice