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, Gallacher D : Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment . Eur. J. Pain. 10 , 287 – 333 ( 2006 ) 5. Christensen D , Gautron M , Guilbaud G , Kayser V : Effect of gabapentin and lamotrigine on

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1986 Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action Epilepsia 27 490 497

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Calabrese, J. R., Bowden, C. L., McElroy, S. L. és mtsai: Spectrum of activity of Lamotrigine in treatment-refracory bipolar disorder. Am. J. Psychiatry, 1999, 156 , 1019

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An HPTLC method with densitometric detection at 280 nm has been established for quantification of lamotrigine in human serum. Liquid-liquid extraction with ethyl acetate, with chloramphenicol as internal standard, was followed by chromatography on silica gel F254 plates with ethyl acetate-methanol-32% aqueous ammonia 17:2:1 (v/v) as mobile phase. The method was validated for linearity, precision, and accuracy. Calibration plots were linear in the range 0.6 to 300 ng per band, corresponding to 0.06–30.00 ng μL−1 lamotrigine in human serum after extraction and application of 1 μL to the chromatographic plate. The correlation coefficient was 0.998. Intra-assay and inter-assay precision, as relative standard deviation (RSD), were in the range 0.53–2.91% (n = 3) and 1.58–2.98% (n = 9), respectively. The limits of detection and quantification were 0.016 and 0.042 ng, respectively. Accuracy, calculated as percentage recovery, was between 94.09 and 101.30%, with RSD no higher than 3.52%. The method was selective for both lamotrigine and the internal standard. The method enables rapid, precise, accurate, selective, and sensitive quantitative analysis of lamotrigine in human serum.

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Orvosi Hetilap
Authors: Lenke Jenei Kluch, Irén Erdei, Éva Remenyik, Éva Surányi, Ferenc Bodnár, Gabriella Emri, and Andrea Szegedi

2020; 75: 781–797. 11 Naisbitt DJ, Farrell J, Wong G, et al. Characterization of drug-specific T cells in lamotrigine hypersensitivity. J Allergy Clin Immunol

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), whereas formic acid and lamotrigine (≥98%), as the internal standard (IS), were obtained from Sigma-Aldrich (St. Louis, MO, USA). Blank human plasma in ethylenediaminetetraacetic acid-tri-potassium anticoagulant (mixed gender) was from Biochemed Services

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and valproic acid: a nation-wide, population-based register study. Acta Paediatr., 2004, 93 (2), 174–176. 3 Sabers, A.: Algorithm for lamotrigine dose adjustment before

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Orvosi Hetilap
Authors: Judit Bene, Kinga Hadzsiev, Katalin Komlósi, Erzsébet Kövesdi, Petra Mátyás, and Béla Melegh

, C., Genton, P., et al.: Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia, 1998, 39 (5), 508–512. 18 Löscher, W.: Preclinical

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37 485 491 Lee, W. T., Shen, Y. Z., Chang, C. (2000) Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3

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. Salari, R. Fayazi, M.T. Shakeri & A.H. Young (2008) ‘Anticonvulsant Treatments of Dysphoric Mania: A Trial of Gabapentin, Lamotrigine and Carbamazepine in Iran’, Neuropsychiatric Disease and Treatment 1, 227

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