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Abstract  

Thermal characterization is proposed as analytical methodology for the purity assay of lapachol, and for determination of the quality parameters of capsules containing this molecule. The TG data revealed that lapachol is more stable in the presence of adjuvants, showing the good quality of the formulation. The kinetic parameters obtained were lower for lapachol drug than for the formulated lapachol. The DSC data demonstrated good compatibility between lapachol drug and the adjuvant in the formulated lapachol, and did not reveal impurities such as secondary products of the isolation and recrystallization processes. The data were confirmed by the DSC-photovisual findings.

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Acta Alimentaria
Authors: F. Budán, I. Szabó, Á. Ember, Ő. Horváth, L. Illényi, Zs. Orsós, A. Blasio, I. Magda, T. Gracza, P. Perjési, T. Dávid, G. Nowrasteh, and I. Ember

Esteves-Souza, A., Figueiredo, D.V., Esteves, A., CÂmara, C.A., Vargas, M.D., Pinto, A.C. & Echevarria, A. (2007): Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA. Braz. J. Med. Biol. Res. , 40 , 1399

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lapachol with pharmaceutical excipients for the development of topical formulations . Thermochim Acta. 2007 ; 457 : 1 – 6 http://dx.doi.org/10.1016/j.tca.2007.02.017 . 14. Verma

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Journal of Thermal Analysis and Calorimetry
Authors: Bogdan Tiţa, Adriana Fuliaş, Zoltan Szabadai, Gerlinde Rusu, Geza Bandur, and Dumitru Tiţa

-009-0347-2 . 20. Lira , AM , Araújo , AAS , Basílio , IDJ , Santos , BLL , Santana , DP , Macedo , RO 2007 Compatibility studies of lapachol with pharmaceutical excipients for the development of topical formulations

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