Thermal characterization is proposed as analytical methodology for the purity assay of lapachol, and for determination of
the quality parameters of capsules containing this molecule. The TG data revealed that lapachol is more stable in the presence
of adjuvants, showing the good quality of the formulation. The kinetic parameters obtained were lower for lapachol drug than
for the formulated lapachol. The DSC data demonstrated good compatibility between lapachol drug and the adjuvant in the formulated
lapachol, and did not reveal impurities such as secondary products of the isolation and recrystallization processes. The data
were confirmed by the DSC-photovisual findings.
Authors:F. Budán, I. Szabó, Á. Ember, Ő. Horváth, L. Illényi, Zs. Orsós, A. Blasio, I. Magda, T. Gracza, P. Perjési, T. Dávid, G. Nowrasteh, and I. Ember
Esteves-Souza, A., Figueiredo, D.V., Esteves, A., CÂmara, C.A., Vargas, M.D., Pinto, A.C. & Echevarria, A. (2007): Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA. Braz. J. Med. Biol. Res. , 40 , 1399