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Introduction Vicia faba, commonly known as “bakla” in Turkey, contains levodopa, a medicine used to treat Parkinson's disease (PD). It belongs to the family of the Fabaceae. Levodopa is found in a variety of natural

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Authors: József Attila Szász, Szabolcs Szatmári, Viorelia Constantin, István Mihály, Attila Rácz, Lajos Csaba Domokos, Tamás Vajda and Károly Orbán-Kis

Parkinson’s before levodopa – carbidopa intestinal gel infusion: Data from 107 tested patients [abstract]. International Congress, October 6, 2018. Mov Disord. 2018; 33(Suppl 2). Available from

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A simple, rapid, specific, and accurate reverse-phase high-performance thin-layer chromatography (RP-HPTLC) method was developed and validated for simultaneous quantification of levodopa, carbidopa, and entacapone in their combined dosage form. Due to the structural similarity between levodopa and carbidopa, and vast difference in their polarity with that of entacapone, it is very challenging to carry out the simultaneous estimation of all three drugs together. In the developed method, chromatography was performed on TLC plates with precoated silica gel 60 RP-18 F254 using acetonitrile-n-butanol-water-triethylamine (0.5:9.5:1:0.001, ν/ν/ν/ν), pH adjusted to 3.6 with o-phosphoric acid, as the mobile phase. Densitometric evaluation was performed at 282 nm. The R F values were 0.46, 0.64, and 0.87 for levodopa, carbidopa, and entacapone, respectively. The polynomial regression data for the calibration plots showed good linear relationship in the concentration range 300–1500 ng per spot for levodopa, 200–1000 ng per spot for carbidopa, and 200–2000 ng per spot for entacapone. The suitability of this HPTLC method for quantitative determination of drugs was proved by validation in accordance with the requirements of the International Conference on Harmonization (ICH) guidelines (Q2B).

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Authors: József Attila Szász, Viorelia Constantin, Péter Alpár Fazakas, Eszter Blényesi, Levente Gábor Grieb, Antal Balla, Mónika Sárig, Kinga Szegedi, Eszter Noémi Bartha and Szabolcs Szatmári

Parkinson’s disease. N Engl J Med. 2009; 361: 1268–1278. 4 Rascol O, Brooks DJ, Melamed E, et al. Rasagiline as an adjunct to levodopa in patients with Parkinson’s disease and

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Authors: Viktor Bencs, János Bencze, V. László Módis, Viktória Simon, János Kálmán and Tibor Hortobágyi

; 14: 191–210. 50 Szász JA, Szatmári Sz, Constantin V, et al. Characteristics of levodopa treatment in advanced Parkinson’s disease in the

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Authors: Mária Csóka, Sándorné Molnár, Éva Kellős and Gyula Domján

Klivényi, P., Vécsei, L.: Clinical studies with levodopa/carbidopa intestinal gel. [Levodopa/carbidopa intestinalis géllel végzett klinikai vizsgálatok.] Ideggyogy. Sz., 2014, 67 (1–2), 5

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Authors: Béla Faludi, József Janszky, Sámuel Komoly and Norbert Kovács

levodopa in Parkinson’s disease. Clin. Neuropharmacol., 2000, 23 (1), 28–33. 11 Iranzo, A.: Parkinson disease and sleep: sleep-wake changes in the premotor stage of

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Authors: Enikő Sáfrány, László Balikó, András Guseo, Bernadett Faragó and Béla Melegh

: Spinocerebellar ataxia type 2 presenting as familial levodopa-responsive parkinsonism. Ann. Neur., 2001, 50 , 812–815. Sun C. M. Spinocerebellar ataxia type 2 presenting as familial

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Authors: Anett Lindner, Márta Novák and Miklós Zsolt Molnár

Benes, H., Kurella, B., Kummer, J. és mtsai: Rapid onset of action of levodopa in restless legs syndrome: a double-blind, randomized, multicenter, crossover trial. Sleep, 1999, 22 , 1073–1081. Kummer J

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Kumakura Y, Danielsen EH, Reilhac A, Gjedde A, Cumming P: Levodopa effect on [18F]fluorodopa influx to brain: normal volunteers and patients with Parkinson’s disease. Acta Neurol. Scand. 110, 188–195 (2004) Cumming

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