& Hollmann, 2008 ; Pérez-Otaño, Larsen, & Wesseling, 2016 ). It has been reported that the expression of NMDA receptors is not limited to the neural cells; other cell types, such as lymphocytes, may also express NMDA receptors ( Boldyrev et al., 2004
18 25 Globerson A, Effros RB: Ageing of lymphocytes and lymphocytes in the aged. Immunol. Today 21, 515–521 (2000) Effros R
733 734 Sinkovics, J. G.: Cytolytic Immune Lymphocytes in the Armamentarium of the Human Host. Schenk Buchverlag, Passau, Pécs, Budapest, 1–418 (2008
, several data verified the presence of hormones in lymphocytes, and also characterized their immune regulatory effects; there is no any data about the connection of the hormone content of immune cells and their differentiation states. The aim of our study
Smith, E.M., Phan, M., Kruger, T.E., Coppenhaver, D.H., Blalock, J.E.: Human lymphocyte production of immunoreactive thyrotropin. Proc Natl Acad Sci USA 80 , 6010–6013 (1983). Blalock J
. 59 31 681 Evans, H. J., O'Riordan, M. L. (1975) Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests
Radiation damage to lymphocyte membranes
II. Structural changes of lipid domain after low doses of high let irradiation
Abstract
The changdes of some physical parameters of lymphocyte membranes following neutron irradiation from a252Cf sourcein vitro in range of very low doses were studied. We aimed our attention at fluorescence intensity, fluorescence polarisation, microviscosity and order parameter of lipid bilayer of lymphocyte membranes. The values of above mentioned parameters were obtained by means of fluorescent spectrometry using 1,6-diphenyl-1,3,5-hexatriene (DPH) as a fluorescent probe. It was shown, that with increasing doses of radiation the values of all studied parameters have been decreasing. The microviscosity of membranes decreased to 37% of the control value.
. Sokol, L., Luoghran, T. P. Jr.: Large granular lymphocyte leukemia. Oncologist, 2006, 11 (3), 263–273. Wlodarsky, M. W., O’Keefe, C., Howe, E. C., et al.: Pathologic clonal cytotoxic T-cell responses: nonrandom
ginsenosides on the growth of mice splenic lymphocytes have not been reported. Splenic lymphocytes are the important cells of immunologic system and play a significant role in host acute or chronic diseases. As the first step for T cell activation
Yoshimura, T., Kurita, C., Yamazaki, F. és mtsai: Lymphocyte stimulation test with tetrazolium-based colorimetric assay for diagnosis of drug-induced allergic hepatitis. Biol. Pharm. Bull., 1994, 17 , 921
