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Abstract  

A study was made of the thermal behavior of the starting materials, their mixtures and the resulting mebendazole tablets. The thermal curves were obtained with a Shimadzu thermobalance, model TGA-50, using an air flow of 50 mL min−1 and a heating rate of 10°C min−1 in the temperature interval 30–900°C. The reaction constant velocities for the mebendazole salt and tablets were determined isothermally, using the Arrhenius expression. The thermal stability of mebendazole tablets is lower than that of the mebendazole salt, due to the presence of starch and lactose in the composition. Analysis of the data reveals that thermogravimetry is a powerful tool in pharmaceutical technology and quality control.

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Abstract  

The objective of this work was to develop and validate a fast and reproducible method able to determine the concentration of mebendazole in raw materials and tablets. The samples were analyzed by dynamic thermogravimetry, in the heating rates of 10, 20, 40, 60 and 80C min–1, in the atmospheres of nitrogen and nitrogen with synthetic air. Obtained data were used in the equations of Antoine and Langmuir, with the purpose to get the pressure curves of those. Vapor pressure curves of drug and tablet of mebendazole were evaluated using the mathematical indexes of difference factor, f 1, and similarity factor, f 2, to compare its profiles. The data showed that there is no significant difference between the vapor pressure profiles of drug and tablet of mebendazole in both environmental conditions studied, what confirms that the process is really vaporization. The concentration of mebendazole was determined in the raw material and tablets with the drug.

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Acta Microbiologica et Immunologica Hungarica
Authors: Balázs Dezsényi, László Sárközi, László Kaiser, Klára Tárkányi, Radka Nikolova, and Zorán Belics

mebendazole, pyrantel pamoate, or albendazole [ 3 ]. In Hungary, benzimidazole derivatives, such as mebendazole and albendazole, are currently available. Data on the use of benzimidazoles in pregnant woman are scarce. A prospective-controlled cohort study that

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Orvosi Hetilap
Authors: Andrea Horváth, Attila Patonay, Dénes Bánhegyi, János Szlávik, György Balázs, Dénes Görög, and Klára Werling

77 Wilson, J. F., Rausch, R. L., McMahon, B. J. és mtsa: Parasiticidal effect of chemotherapy in alveolar hydatid disease: review of experience with mebendazole and

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Acta Veterinaria Hungarica
Authors: T. Müller, T. Molnár, Éva Szabó, R. Romvári, Cs. Hancz, M. Bercsényi, and P. Horn

. 50 475 486 Székely, Cs. and Molnár, K. (1987): Mebendazole is an efficacious drug against pseudodactylogyrosis in the European eel ( Anguilla

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. 11 31 35 Székely, Cs., Molnár, K. (1987) Mebendazole is an efficacious drug against pseudodactylogirosis in the European eel (Anguilla anguilla

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Acta Veterinaria Hungarica
Authors: Alenka Dovč, Gordana Gregurić Gračner, Iztok Tomažič, Ksenija Vlahović, Marina Pavlak, Renata Lindtner Knific, Klemen Kralj, Mateja Stvarnik, and Aleksandra Vergles Rataj

): Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur ( Lemur catta ), China . Parasitol. Res. 111 , 935 – 937 . Lynne , S. G. ( 2007

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. Székely , Cs. and Molnár , K. ( 1987 ): Mebendazole is an efficacious drug against pseudodactylogyrosis in the European eel (Anguilla anguilla) . J. Appl. Ichthyol. 3 , 183 – 186

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Journal of Thermal Analysis and Calorimetry
Authors: Agna Hélia de Oliveira, Elisana Afonso de Moura, Márcia Ferraz Pinto, José Valdilânio Virgulino Procópio, Valmir Gomes de Souza, Fábio Santos de Souza, and Rui Oliveira Macêdo

-6031(02)00088-6 . 20. Gomes , APB , Correia , LP , Simões , MOS , Macêdo , RO . Development of thermogravimetric method to quantitative determination of mebendazole . J Therm Anal Calorim . 2007 ; 87 : 919 – 925 . 10.1007/s10973

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)–densitometry methods. The model process was applied earlier to formulations containing acetylsalicylic acid, acetaminophen, ibuprofen, and chlorpheniramine maleate [ 1 ]; mebendazole, diphenhydramine HCl, amodiaquine, and artesunate [ 2 ]; amodiaquine and diazepam [ 3

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