Authors:Rui Macêdo, Antonio Gouveia de Souza, Ana Miriam, and Carvalho Macêdo
A study was made of the thermal behavior of the starting materials, their mixtures and the resulting mebendazole tablets.
The thermal curves were obtained with a Shimadzu thermobalance, model TGA-50, using an air flow of 50 mL min−1 and a heating rate of 10°C min−1 in the temperature interval 30–900°C. The reaction constant velocities for the mebendazole salt and tablets were determined
isothermally, using the Arrhenius expression. The thermal stability of mebendazole tablets is lower than that of the mebendazole
salt, due to the presence of starch and lactose in the composition. Analysis of the data reveals that thermogravimetry is
a powerful tool in pharmaceutical technology and quality control.
Authors:Ana Gomes, Lidiane Correia, Mônica da Silva Simões, and Rui Macêdo
The objective of this work was to develop and validate a fast and reproducible
method able to determine the concentration of mebendazole in raw materials
and tablets. The samples were analyzed by dynamic thermogravimetry, in the
heating rates of 10, 20, 40, 60 and 80C min–1,
in the atmospheres of nitrogen and nitrogen with synthetic air. Obtained data
were used in the equations of Antoine and Langmuir, with the purpose to get
the pressure curves of those. Vapor pressure curves of drug and tablet of
mebendazole were evaluated using the mathematical indexes of difference factor, f1, and similarity factor, f2, to compare its profiles.
The data showed that there is no significant difference between the vapor
pressure profiles of drug and tablet of mebendazole in both environmental
conditions studied, what confirms that the process is really vaporization.
The concentration of mebendazole was determined in the raw material and tablets
with the drug.
Authors:Balázs Dezsényi, László Sárközi, László Kaiser, Klára Tárkányi, Radka Nikolova, and Zorán Belics
mebendazole, pyrantel pamoate, or albendazole [ 3 ]. In Hungary, benzimidazole derivatives, such as mebendazole and albendazole, are currently available. Data on the use of benzimidazoles in pregnant woman are scarce. A prospective-controlled cohort study that
)–densitometry methods. The model process was applied earlier to formulations containing acetylsalicylic acid, acetaminophen, ibuprofen, and chlorpheniramine maleate [ 1 ]; mebendazole, diphenhydramine HCl, amodiaquine, and artesunate [ 2 ]; amodiaquine and diazepam [ 3