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critical and rate-limiting step in the development process and present great potential for new enabling technologies and innovations. In this regard, there have been exciting advancements in the medicinal chemistry optimization toolbox. For example

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JPC - Journal of Planar Chromatography - Modern TLC
Authors: Genowefa Misztal, Beata Paw, Robert Skibiński, Łukasz Komsta and Joanna Kołodziejczyk

. 1983 3 21 42 A. Gringauz , Introduction to Medicinal Chemistry, Wiley-VCH, New York, 1997

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Journal of Flow Chemistry
Authors: Klára Lövei, István Greiner, János Éles, Áron Szigetvári, Miklós Dékány, Sándor Lévai, Zoltán Novák and György István Túrós

In medicinal chemistry, the development of synthetic procedures for the access of new heterocyclic systems as potential scaffolds is elementary. Herein, we report our results on the formation of small drug-like heterocycles, utilizing flow chemistry. This approach enables the extension of the reaction parameter window, including high-pressure/high-temperature or hazardous chemistry. In our work, various novel condensed tricyclic benzothiazoles fused with furo- and thieno-rings were synthesized applying a multistep continuous-flow protocol. The process includes two ring closure steps and a nitro group reduction step. Batch and telescoped continuous-flow syntheses were also designed and performed.

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Abstract  

Technetium(I) tricarbonyl complexes may form with the pyridine aldehyde thiosemicarbazones (TSCs), in which chelating ligand is bound tri- or bidentately. Intend of the presented work was to check, if labeling the N-heterocyclic TSCs with tricarbonyl [99mTc]-technetium(I) may lead to formation of the complexes suitable for the radiopharmaceutical purposes. Syntheses of the complexes were provided in the conditions analogous to those performed in the nuclear medicine laboratories. Main physicochemical properties of the complexes important in the medicinal chemistry were studied. Relevant results of the numerical calculations remain in fair agreement with these properties.

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Abstract  

Vic-dioxime ligandsand their metal complexes are used in analytical, bio, pigment and medicinal chemistry. Complexes of nickel(II), copper(II), and cobalt(II) with benzylamino-p-chlorophenylglyoxime (BpCPG) are synthesised. Thermal behaviour of these complexes was studied in dynamic nitrogen atmosphere by DTA, DTG and TG techniques. GC-MS combined system was used to identify the products during pyrolytic decomposition. The pyrolytic end products were identified by X-ray powder diffraction. Thermoanalytical data of these complexes are presented in this communication. Interpretation and mathematical analysis of these data and evaluation of order of reaction, the energy and entropy of activation based on the integral method using the Coats-Redfern equation and the approximation method using the Horowitz-Metzger equation are also given. The metal complexes undergo decomposition in three stages and metal oxides remained as end products of the complexes.

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JPC - Journal of Planar Chromatography - Modern TLC
Authors: Mirjana Aleksic, Slavica Eric, Danica Agbaba, Jadranka Odovic, Dušica Milojkovic-Opsenica and Živoslav Tesic

30 123 132 W.O. Foye, T.L. Lemke , and D.A. Williams , Principles of Medicinal Chemistry, 4th edn, Williams and Wilkins, USA

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JPC - Journal of Planar Chromatography - Modern TLC
Authors: Jelena Veličković, Deana Andrić, Goran Roglić, Živoslav Tešić and Dušanka Milojković-Opsenica

) 1987 Gareth Thomas , Medicinal Chemistry, Wiley, Chichester, UK, 2000. Thomas G

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) Medicinal Chemistry and Drug Discovery, John Wiley and Sons, Hoboken, New Jersey, 2003. Medicinal Chemistry and Drug Discovery 2003

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N.P. Gensmantel , Physicochemical Properties and Drug Design. In: F.D. King (Ed.) Medicinal Chemistry: Principles and Practice, Royal Society of Chemistry, Cambridge, 2001, pp. 98

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.), Burger’s Medicinal Chemistry and Drug Discovery, Vol. 5, Wiley, New York, 1997, p. 183. Burger’s Medicinal Chemistry and Drug Discovery, Vol. 5 1997

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