Authors:Gary Perkins, Omar Khatib, Matthew Peterson, Annukka Kallinen, Tien Pham, Alison Ung, Ivan Greguric and Giancarlo Pascali
Carbon dioxide chemistry is an area of continuing growth in recent times, due to socioeconomic and environmental reasons. Several methods have now been reported for obtaining N-methylation on primary and secondary amines directly from CO2. We have translated in two microfluidic setups (Slug Flow [SF] and Tube-in-Tube [TiT]) a ruthenium (Ru)-catalyzed process previously reported using a pressure vessel. Here, we demonstrate how the SF approach is more efficient but requires more input to reach a steady state, while the TiT system is less efficient but more tuneable.We have tested these processes on three model amines and two radiopharmaceutical precursors that are routinely used in 11C chemistry. The microfluidic processes tested are also potentially more efficient than the pressure vessel counterpart, in terms of amount of Ru catalyst needed (1% vs. 10%) and projected reaction completion time.
Arnholdt-Schmitt, B., Herterich, S., Neumann, K. H. (1995) Physiological aspects of genome variability in tissue culture. I. Growth phase-dependent differential DNA methylation of the carrot genome ( Daucus
Authors:Muhammad Saad, Helen Mary, Umar Amjid, Ghulam Shabir, Kashif Aslam, Shahid Masood Shah and Abdul Rehman Khan
Different epigenetic marks like DNA methylation and histone modification play their role in modulating the plant stress response. Among these, DNA methylation is most stable epigenetic mechanism that can have implications in crop
Authors:Denis N. Jumbam, Ryan A. Skilton, Andrew J. Parrott, Richard A. Bourne and Martyn Poliakoff
This paper describes the next stage in our development of self-optimising reactors. We demonstrate that the same reaction can be optimised for a series of different criteria including yield, space–time yield, E factor and a weighted yield function (the product of space–time yield and yield). In different experiments, we achieved 97.6% yield, space–time yield of 42.9 kg/L/h and E factors of 1.4 and 3.3 (including CO2) and the weighted yield, which gave a promising balance between yield, E factor and space–time yield.
Authors:Orsolya Dóra Ács, Bálint Péterfia, Péter Hollósi, Irén Haltrich, Ágnes Sallai, Andrea Luczay, Karin Buiting, Bernhard Horsthemke, Dóra Török, András Szabó and György Fekete
Wang W, Law HY, Chong SS. Detection and discrimination between
deletional and non-deletional Prader–Willi and Angelman syndromes by
methylation-specific PCR and quantitative melting curve analysis