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this study. It was cloned into TOPO-100 expression vector and alanine mutations were generated as follows: NDM-2 (P28A), NDM-3 (D95A), NDM-4 (M154A), NDM-5 (V88A), NDM-7 (D130A), and NDM-9 (E152A). Changes in the activities of the alanine mutation
Authors:Elham Rayzan, Gholamreza Pouladfar, Nima Parvaneh, Mohammad Shahrooei, Zahra Aryan, and Nima Rezaei
). Defects in each subunit of PHOX can lead to CGD [ 2 , 3 ].
The assembled NADPH oxidase complex activity. Defective activity of each component will result in CGD. CYBA - 16q24 - mutation is responsible