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Thermal stability study of the protease inhibitors

Nelfinavir mesylate and atazanavir sulfate

Journal of Thermal Analysis and Calorimetry
Authors: Katarzyna Michalik, Zofia Drzazga, Anna Michnik, and M. Kaszuba

Abstract  

A thermal and kinetic analysis of two protease inhibitors: nelfinavir mesylate and atazanavir sulfate, were carried out to find their thermal stability. DSC curves of both drugs showed exothermic transition. This observed process resulted in two steps. Obtained apparent activation energy pointed at low stability of studied protease inhibitors in water solutions.

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Journal of Thermal Analysis and Calorimetry
Authors: M. Łaszcz, K. Trzcińska, K. Filip, A. Szyprowska, M. Mucha, and P. Krzeczyński

. Thermal stability study of the protease inhibitors Nelfinavir mesylate and atazanavir sulfate . J Therm Anal Calorim . 2007 ; 88 : 401 – 404 . 10.1007/s10973-006-8128-7 . 6. Howell , BA

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Labs Ltd. (Mumbai, India) while RIF and nelfinavir mesylate hydrate (NELF) were obtained from Sigma-Aldrich (Steinheim, Germany). HPLC-grade acetonitrile, methanol, and ethanol were purchased from Sigma-Aldrich (Steinheim, Germany) and ethyl acetate

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