Authors:Katarzyna Michalik, Zofia Drzazga, Anna Michnik, and M. Kaszuba
and kinetic analysis of two protease inhibitors: nelfinavir mesylate and atazanavir
sulfate, were carried out to find their thermal stability. DSC curves of both
drugs showed exothermic transition. This observed process resulted in two
steps. Obtained apparent activation energy pointed at low stability of studied
protease inhibitors in water solutions.
Authors:Saneesh Kumar, Patrick J. Bouic, and Bernd Rosenkranz
Labs Ltd. (Mumbai, India) while RIF and nelfinavirmesylate hydrate (NELF) were obtained from Sigma-Aldrich (Steinheim, Germany). HPLC-grade acetonitrile, methanol, and ethanol were purchased from Sigma-Aldrich (Steinheim, Germany) and ethyl acetate