Authors:Zsuzsanna Lengyel, Anita Lukács, Andrea Szabó, and L. Institóris
Three different insecticides: dimethoate, cypermethrin and amitraz were given, alone or combined with the heavy metals Pb, Hg and Cd, to male Wistar rats per os for 12 weeks from their 4th week of life. After the treatment period, the left hemisphere of the rats was exposed in urethane anaesthesia, and spontaneous and evoked cortical activity was recorded from the primary sensory areas. The effects of dimethoate on the spontaneous activity, and of dimethoate and amitraz on the evoked responses, were increased by the metal combination treatment, whereby the metals alone had no effect on the spontaneous and mild effect on the evoked activity. Finally, the animals were dissected, organ weights measured, and relative organ weights calculated. The weight gain of all treated groups was significantly retarded compared to the control. Several organ weights were also significantly reduced, mainly in groups receiving insecticide plus metal treatment. The toxic interactions observed in this work indicate that combined human exposure to environmental pesticide residues and heavy metals may have unexpectedly severe effects.
Authors:Oliwier Teodorowski, Łukasz Adaszek, Mehmet Erman Or, Banu Dokuzeylül, Alev Meltem Ercan, Duygu Tarhan, Marta Staniec, and Stanisław Winiarczyk
far, no studies have been conducted to determine the serum concentration of manganese in dogs with babesiosis. Manganese (Mn) is neurotoxic when present in excessive concentrations ( Racette et al., 2017 ). The mechanism of neurotoxicity appears to be
Authors:Laura von Brzezinski, Paula Säring, Peter Landgraf, Clemens Cammann, Ulrike Seifert, and Daniela C. Dieterich
Application of the proteasome inhibitor Bortezomib for the treatment of haematopoietic malignancies such as multiple myeloma significantly improves the average overall survival of patients. However, one of the most severe side effects is the development of peripheral neuropathies caused by neurotoxic effects of Bortezomib limiting its therapeutic efficacy. With ONX-0914 a specific inhibitor of the β5i (LMP7)-immunosubunit containing proteasomes was developed that targets exclusively the proteasome subtypes mainly expressed in immune cells including B lymphocytes as the origin of multiple myeloma. Furthermore, immunosubunitspecific inhibitors have been shown to be promising tools for the therapy of autoimmune disorders. In the presented study, we analysed the concentration-dependent impact of both inhibitors on primary neurons regarding survival rate, morphological changes, and overall viability. Our results clearly demonstrate that ONX-0914, compared to Bortezomib, is less neurotoxic suggesting its potential as a putative antineoplastic drug and as a candidate for the treatment of autoimmune disorders affecting the peripheral and/or central nervous system.
Authors:Ilona Banczerowski-Pelyhe, Petra Varró, and Ildikó Világi
Neurotoxicity Testing (2004)
Silva RF, Falcao AS, Fernandes A, Gordo AC, Brito MA, Brites D. (2005): Dissociated primary nerve cell cultures as models for assessment of neurotoxicity. Toxicol. Lett. (Epub ahead of print: Pubmed