. a process associated with “degrading” functional disorders or disease; 2. whereas “normalageing” is a process in which the reduction in function is continuous but does not involve diseases or other pathological processes 3. and in “successful ageing
Authors:D. Cutts, R. Maguire, K. Leenders, and N. Spyrou
In the 'normal' ageing brain a decrease in the cerebral metabolic rate has been determined across many brain regions. This
study determines whether age differences would affect metabolic rates in regions and different hemispheres of the brain. The
regional metabolic rate of glucose (rCMRGlu) was examined in a group of 72 subjects, ages 22 to 82 years, with 36 regions
of interest chosen from both hemispheres of the cortex, midbrain and cerebellum. To determine metabolic rates the in-vivo
technique of positron emission tomography (PET) was employed. Three age groups were chosen to compare hemispherical differences.
In both young and intermediate age groups the left hemisphere had higher rCMRGlu values than those of the right for the majority
of regions with, although less pronounced in the intermediate group. Importantly, the older age group displayed little difference
Thirteen brain regions were dissected from both hemispheres of fifteen ‘normal’ ageing subjects (8 females, 7 males) of mean
age 79±7 years. Elemental compositions were determined by simultaneous application of particle induced X-ray emissions (PIXE)
and Rutherford backscattering (RBS) analyses using a 2 MeV, 4nA proton beam scaned over 4 mm2 of the sample surface. Elemental concentrations were found to be dependent upon the brain region and hemisphere studied.
Hierarchical cluster analysis was applied to group the brain regions according to the sample concentrations of eight elements.
The resulting dendrogram is preseted and its clusters related to the sample compositions of grey and white matter.
Authors:Henrietta Papp, I. Török, A. Matsumoto, T. Enomoto, S. Matsuyama, and P. Kása
neurofibrillary tangles in subdivisions of the hippocampal cortex in normalageing and Alzheimer's disease. Neurosci. Lett. 200 , 57-60.
Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal