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Introduction The octapeptide NAP consists of eight amino acids (namely, NAPVSIPQ) and was initially identified as a biologically active fragment of the activity-dependent neuroprotective protein (ADNP) [ 1 ]. Human ADNP is not

Open access
European Journal of Microbiology and Immunology
Authors: Markus M. Heimesaat, André Fischer, Anja A. Kühl, Ulf B. Göbel, Illana Gozes and Stefan Bereswill

The octapeptide NAP has been shown to exert neuroprotective properties. Here, we investigated potential anti-inflammatory effects of NAP in an acute ileitis model. To address this, C57BL/6j mice were perorally infected with Toxoplasma gondii (day 0). Within 1 week postinfection (p.i.), placebo (PLC)-treated mice developed acute ileitis due to Th1-type immune responses. Mice that were subjected to intraperitoneal NAP treatment from day 1 until day 6 p.i., however, developed less distinct macroscopic and microscopic disease as indicated by less body weight loss, less distinct histopathological ileal changes, and lower ileal apoptotic, but higher proliferating cell numbers, less abundance of neutrophils, macrophages, monocytes, and T lymphocytes, but higher numbers of regulatory T cells in the ileal mucosa and lamina propria, and lower concentrations of pro-inflammatory mediators in the ilea as compared to PLC controls at day 7 p.i. Remarkably, NAP-mediated anti-inflammatory effects could also be observed in extra-intestinal compartments including liver and spleen. Strikingly, lower MCP-1, TNF, and IL-12p70 serum concentrations in NAP as compared to PLC-treated mice at day 7 p.i. indicate a pronounced systemic anti-inflammatory effect of NAP in acute ileitis. These findings provide first evidence for NAP as a potential novel treatment option in intestinal inflammation.

Open access

Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis . Eur J Microbiol Immunol . 2018 ; 8 : 34 – 40 . doi: 10.1556/1886.2018.00006 . PubMed PMID: 29997909; PubMed Central PMCID: PMCPMC6038539. 43

Open access

Gozes , I . The octapeptide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis . Peptides. 2018 ; 101 : 1 – 9 . 10.1016/j.peptides.2017.12.023 22

Open access