* Advanced Synthesis and Catalysis 2013 , 355 , 209 – 219 .
“ Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors ” A. Nagaki , Y. Uesugi , H. Kim , J.-i. Yoshida * Chemistry — An
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“Continuous flow synthesis of ketones from carbon dioxide and organolithium or grignard reagents” J. Wu, X. Yang, Z. He, X. Mao, T
synthesized using different methods [ 1 , 6 ]. However, a few methods are available for the organometallic synthesis of sulfones and they depend on the use of sulfonyl chlorides or sulfonate esters. Sulfonyl chlorides react with organolithium or Grignard
leveraged the enhanced mixing capabilities in flow to improve the performance of an organometallic reaction (Scheme 5 ) [ 33 ]. Rapid metalation and organolithium addition to a chiral ketamine in flow allowed for improved yield (↑18%), efficiency (<1 s τ