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Acta Veterinaria Hungarica
Authors: Sanja Srzentić Dražilov, Janko Mrkovački, Vesna Spasovski, Amira Fazlagić, Sonja Pavlović, and Gordana Nikčević

regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs . Vet. Ther. 9 , 192 – 200 . Black , L. L. , Gaynor , J. , Gahring , D. , Adams , C. , Aron

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Felson DT, Thang Y: An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis and Rheumatism 41, 1343–1355 (1998) Thang Y. An update on the

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Orvosi Hetilap
Authors: Gábor Horváth, Gabriella Koroknai, Barnabás Ács, Péter Than, Árpád Bellyei, and Tamás Illés

reliability, questionable validity of 25 different classification criteria of knee osteoarthritis: a systematic appraisal. J. Clin. Epidemiol., 2008, 61 , 1205–1215. Koes B. W. Good

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Interventional Medicine and Applied Science
Authors: Sirous Azizi, Afsaneh Dadarkhah, Zahra Rezasoltani, Seyed Ahmad Raeissadat, Reza Kazempoor Mofrad, and Sharif Najafi

Introduction Knee osteoarthritis is a common form of arthritis identified by the physician in daily practice [ 1 ]. The prevalence of the disease is about 28% among the population over the age of 45 years, and people over 63 years

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Orvosi Hetilap
Authors: Margit Szentesi, Zoltán Nagy, Pál Géher, István Papp, and W. Uwe Kampen

Conaghan PG, Kloppenburg M, Schett G, et al. Osteoarthritis research priorities: a report from a EULAR ad hoc expert committee. Ann Rheum Dis. 2014; 73: 1442–1445. 3

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Introduction Osteoarthritis (OA) is a degenerative joint disease characterized by chronic pain, stiffness, and erosion in the cartilage, which subsequently decreases the quality of life in patients. Although it affects the joints in fingers, wrists

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Summary  

Arthritis of major joints, especially osteoarthritis of the knee is a very frequent disease of human beings mainly in the developed countries. The pathology of osteoarthritis has been subject of many publications before, using a wide spectrum of different methods to evaluate degenerative changes of hyaline cartilage. The authors examined osteoarthritic human knee joint hyaline cartilage with differential scanning calorimetry. The different stages of cartilage degeneration have been verified by histological examinations. The research group demonstrated thermal differences between various stages of osteoarthritis. Besides explaining possible causes for experienced thermodynamic effects, the authors reflect upon future research ways and the possibilities of applying the method in practice.

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Abstract  

The purpose of this investigation was to further elucidate calorimetric properties of cartilage samples from femoral head necrosis and osteoarthritis from live surgeries. The natural course of this disease is one of steady progression with eventual collapse of the femoral head, followed by secondary osteoarthritis in the hip joint. All samples showed a clear denaturation peak on the calorimetric curve. Cartilage obtained from necrotic femoral head required the lowest amount of energy for decomposition. The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating.

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Abstract  

Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in the extracellular matrix in osteoarthritis comes from animal models. Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which proved water content elevation contributing to disease progression.

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Orvosi Hetilap
Authors: Eszter Kővári, Ambrus Kaposi, Zsuzsanna Kiss, Réka Kurucz, Péter Mandl, Géza Péter Bálint, Gyula Poór, Miklós Szendrői, and Péter Vince Bálint

References 1 Bitton R. The economic burden of osteoarthritis. Am J Manag Care 2009; 15(Suppl): S230–S235. 2

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