Authors:Sirous Azizi, Afsaneh Dadarkhah, Zahra Rezasoltani, Seyed Ahmad Raeissadat, Reza Kazempoor Mofrad, and Sharif Najafi
Introduction Knee osteoarthritis is a common form of arthritis identified by the physician in daily practice [ 1 ]. The prevalence of the disease is about 28% among the population over the age of 45 years, and people over 63 years
Authors:Sara Asadi, Parvin Farzanegi, and Mohammad Ali Azarbayjani
Introduction Osteoarthritis (OA) is a degenerative joint disease characterized by chronic pain, stiffness, and erosion in the cartilage, which subsequently decreases the quality of life in patients. Although it affects the joints in fingers, wrists
Arthritis of major joints, especially osteoarthritis of the knee is a very frequent disease of human beings mainly in the
developed countries. The pathology of osteoarthritis has been subject of many publications before, using a wide spectrum of
different methods to evaluate degenerative changes of hyaline cartilage. The authors examined osteoarthritic human knee joint
hyaline cartilage with differential scanning calorimetry. The different stages of cartilage degeneration have been verified
by histological examinations. The research group demonstrated thermal differences between various stages of osteoarthritis.
Besides explaining possible causes for experienced thermodynamic effects, the authors reflect upon future research ways and
the possibilities of applying the method in practice.
Authors:Z. Aigner, L. Mécs, G. Sohár, K. Wellinger, Piroska Szabó-Révész, and K. Tóth
The purpose of this investigation was to further elucidate calorimetric properties of cartilage samples from femoral head
necrosis and osteoarthritis from live surgeries. The natural course of this disease is one of steady progression with eventual
collapse of the femoral head, followed by secondary osteoarthritis in the hip joint. All samples showed a clear denaturation
peak on the calorimetric curve. Cartilage obtained from necrotic femoral head required the lowest amount of energy for decomposition.
The use differential scanning calorimetry as part of thermal analysis was a reliable method for differentiating.
Authors:G. Sohár, E. Pallagi, P. Szabó-Révész, and K. Tóth
Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly
well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well
as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in
the extracellular matrix in osteoarthritis comes from animal models.
Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative
human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which
proved water content elevation contributing to disease progression.