Search Results

You are looking at 1 - 10 of 22 items for :

  • "osteonecrosis" x
Clear All

–2768. Brozoski, M. A., Traina, A. A., Deboni, M. C., et al.: Bisphosphonate-related osteonecrosis of the jaw. Rev. Bras. Reumatol., 2012, 52 (2), 265–270. Ruggiero, S. L., Dodson, T. B., Fantasia, J., et al.: American

Restricted access
Authors: G. Bognár, Cs. Pintér, B. Horváth, T. Sydo, E. Ligeti, J. Pulai and D. Lőrinczy

Abstract  

Osteonecrosis (ON) of the femoral frequently occurs after steroid medication. One of the final pathways leading to steroid induced ON is thought to be pathologic fat metabolism. The pathobiological mechanism underlying the induction of fat metabolism outslides by steroids leading to ON has not been fully elucidated. The purpose of this study was to examine the intraoperative obtained gluteal fat tissue from ON patients with histology, gas chromatography (GC) and differential scanning calorimetry (DSC) and to compare them with otherwise healthy patient’s samples. The histological sections showed no significant differences compared with the control group. GC revealed that fraction of saturated fatty acids decreased in ON samples from mean values of controls of 24% to 21, the polyunsaturated fraction from 20 to 14%. The monounsaturated acids showed an increase from mean rate of 52% of the controls to 65% of steroid treated samples. DSC curves correlate with chromatographic analysis of the tissue fatty acids (Steroid treated, heating between 0–100°C: Tm=5.7°C, ΔH= −15.8J/g−1; heating between −20–100°C: Tm= −9.96 and 5.85°C, ΔH= −59.17 and −16.2 J g−1. Non-necrotic, heating between 0–100°C: two separable transition with Tm=5.7 and 9.9°C, total ΔH= −20.8 J g−1; heating between −20–100°C: Tm= −10.9 and 4.95°C, total ΔH= −75.8 J g−1.) Our preliminary findings are rather tendentious. Further investigations are needed with higher sample rate and under other anamnestic circumstances too.

Restricted access

References 1 Christodoulou, C., Pervena, A., Klouvas, G., et al.: Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the

Restricted access
Authors: Ferenc Koppány, Árpád Joób-Fancsaly, Zsolt Németh, Andrea Alexandra Belik, Mihály Vaszilkó, Edvárd Márton Varmuzsa and Krisztián Benedek Csomó

-related osteonecrosis of the jaw – 2014 update. J Oral Maxillofac Surg. 2014; 72: 1938–1956. [Correction: J Oral Maxillofac Surg. 2015; 73: 1440.] [Published correction: J Oral Maxillofac Surg. 2015; 73: 1879

Open access
Authors: Cs. Pintér, G. Bognár, B. Horváth, T. Sydo, E. Ligeti, J. Pulai and D. Lőrinczy

Abstract  

The osteonecrosis or avascular necrosis of the antero-superior part of the human femoral head (ANFH) often causes incongruity in the hip joint and leads to severe pain and disability in middle aged patients. This abnormality often requires surgical intervention, mainly total hip arthroplasty (THA). The possible pathomechanisms of ANFH are fat embolism, arterial occlusion, fatty necrosis of osteocytes and intraosseous hypertension. Factors have been proposed in the literature that can lead to this condition are alcohol abuse, steroid therapy, metabolic changes, dyslipidaemia. In some case we can not verify any factor; these are the so called idiopathic ANFH cases. We observed macroscopic variation in colour and consistency of the subcutaneous fat tissue in patients with ANFH compared to osteoarthritis or hip fracture during THA procedures. Subcutaneous fat tissues during THA from a patient with ANFH due to alcohol abuse were compared with an otherwise healthy patient who underwent surgery due to traumatic hip fracture. No histological changes were notified in the size; shape of adipocytes and in the cells of the septae of the connective tissue. Gas chromatography showed that the patient with alcoholic ANFH had less long chain fatty acids. DSC revealed, that in case of non-necrotic sample as a reference, during heating between 0–100°C two separable transitions are with T m=5.7 and 9.9°C, total ΔH= −20.8 J g−1. In −20–100°C range endotherms with T m= −10.9 and 4.95°C, total ΔH= −75.8 J g−1 could be detected. In case of alcohol-induced avascular necrosis we have found endotherms between 0–100°C with: T m=7.3°C, total ΔH= −26.9 J g−1, and heating between −20–100°C: T m= −0.25°C, total ΔH= −103.3 J g−1 thermal parameters. The alteration in the fatty acid profile did not cause histological changes, but we were able to detect it with analytical methods e.g. DSC and gas chromatography.

Restricted access
Authors: Cs. Pintér, G. Bognár, B. Horváth, T. Sydo, E. Ligeti, J. Pulai and D. Lőrinczy

Abstract  

Avascular necrosis of human femoral head (ANFH) causes incongruity in the joint that leads to disability in patients requires total hip arthroplasty (THA). Several etiological factors of ANFH have been proposed in the literature but there are cases of idiopathic origin. We observed macroscopic variation in quality of the subcutaneous fat tissue in patients with ANFH compared to patients with osteoarthritis or hip fracture during THA procedures. The samples were analysed by histology, gas chromatography (GC) and differential scanning calorimetry (DSC). Conclusion: the alteration in the fatty acid profile did not cause histological changes, however we could detect biochemical changes using DSC and GC.

Restricted access

Soós B, Vajta L, Szalma J. Sunitinib and zoledronic acid induced osteonecrosis of the jaw. [Sunitinib és zoledronsav által indukált állcsont-osteonecrosis.] Orv Hetil. 2015; 156: 1865

Open access

Biszfoszfonát-kezelés során fellépő állcsontnecrosis

Gyakorlati útmutató a biszfoszfonáttal kezelt betegeknél fellépő osteonecrosis megelőzéséhez és kezeléséhez

Authors: Enikő Udvardy, Pál Redl and Ildikó Márton

Irodalom 1. L Assael 2004 New foundations in understanding osteonecrosis of the jaws J Oral Maxillofac

Restricted access
Authors: Szófia Szentpéteri, László Restár, Zsolt Németh and Mihály Vaszilkó

References 1 Wang J, Goodger NM, Pogrel MA. Osteonecrosis of the jaws associated with cancer chemotherapy. J Oral Maxillofac Surg. 2003; 61: 1104

Open access

–1117. 2 Ruggiero SL, Dodson TB, Assael LA, et al. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws – 2009 update. J Oral Maxillofac

Open access