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. De Bont, M. P., Wilderjans, H. and Simon, O. (2010): Standing laparoscopic ovariectomy technique with intraabdominal dissection for removal of large pathologic ovaries in mares. Vet. Surg. 39 , 737–741. Simon

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-brain barrier disruption during focal cerebral ischemia in younger and older rats Horm. Metab. Res. 2006 38 377 381 Cipolla MJ, Godfrey JA, Wiegman MJ: The effect of ovariectomy and estrogen on

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Messinis IE, Kariotis I Milingos S, Kollios G, Seferiadis K: Treatment of normal women with oestradiol plus progesterone prevents the decrease of leptin concentrations induced by ovariectomy. Hum. Reprod. 15, 2383-2387 (2000

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Committee of Capital Medical University, Beijing, China (IAEC/CMU/2019/08). Induction of osteoporosis and treatment Bilateral ovariectomies were performed in accordance with a previously reported study [ 12 ]. All animals were anaesthetised. An incision of

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Ha BJ: Oxidative stress in ovariectomy menopause and role of chondroitin sulfate. Arch. Pharm. Res. 27(8), 867–872 (2004) Ha B.J. Oxidative stress in ovariectomy menopause and role

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The effect of 40% partial food deprivation was studied on the immunohistochemically detectable amount of glial fibrillary acidic protein (GFAP) — the specific marker of astroglia — in the dorsal subnucleus of lateral septum (LS) of male, intact and ovariectomized (OVX) female rats. Animals were either fed ad libitum (control) or 40% food deprived for one week, then perfusion-fixed, their brains removed, and serial vibratome sections were processed for the immunocytochemical localization of GFAP. Computeraided densitometry was carried out on digital photographs.The results showed that ovariectomy alone did not exert any effect on the density of GFAPimmunoreactivity (GFAP-IR) as compared to the values detected in intact females. Food deprivation increased the density of GFAP in each experimental group. The difference was most pronounced in males, significant in females and much less in ovariectomized females. Parietal cortex chosen as reference area did not show any increase in the local GFAP-IR.It was previously shown that the dorsal subnucleus of the lateral septum reacts with plastic neurochemical changes to food deprivation. Our results prove that these changes affect not only neuronal but also glial elements.

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405 412 Fedotova J: Effects of mild, moderate and severe stress on depression in female rats: modifications by estrous cycle, ovariectomy and estradiol treatment. Biol. Psychiat

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Acta Physiologica Hungarica
Authors: F. Saffarzadeh, M. Eslamizade, H. Nemati Karimooy, M. Hadjzadeh, M. Khazaei, and Mahmoud Hosseini

Ha BJ: Oxidative stress in ovariectomy menopause and role of chondroitin sulfate. Arch. of Pharmacol. Res. 27, 867–872 (2004) Ha B.J. Oxidative stress in ovariectomy menopause and

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447 452 Monteiro SC, Matte C, Delwing D, Wyse ATS: Ovariectomy increases Na, K-TPase, acetylcolinesterase and catalase in rat hippocampus. Molecular and Cellular Endocrinology

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The purpose of this work was to study the role of 5-HT1A receptors on the level of anxiety in adult intact and ovariectomized (OVX) female rats. The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) given for 14 days alone or in combination with 17µ-estradiol (0.5 µg i.m./rat/day) was studied on behavior in the elevated plus maze. In intact females administration of NAN-190 resulted in significant increase in the number of enterings and the time spent on the open arms in every phase of the estrous cycle, however, 8-OH-DPAT failed to modify these parameters. In OVX females 8-OH-DPAT alone or in combination with 17µ-estradiol significantly increased the number of enterings and time spent on the open arms. On the contrary, NAN-190 alone or in combination with 17µ-estradiol in OVX females failed to evoke behavioral changes in the elevated plus maze. Thus, the 5-HT1A receptor antagonist NAN-190 induced anxiolytic effect in intact female rats, while 5-HT1A receptor agonist 8-OH-DPAT produced an anxiolytic profile on OVX rats. Results of this work specify the involvement of 5-HT1A receptors in behavioral mechanisms of anxiety in OVX female rats.

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