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Journal of Thermal Analysis and Calorimetry
Authors: Á. Beretzky, P. Kása, K. Pintye-Hódi, J. Bajdik, P. Szabó-Révész, and I. Erős

Abstract  

The flowability of needle- or plate-shaped crystals is very poor and the direct compression of these crystals is difficult. Commercial phenylbutazone consists of needle crystals and it has three polymorphs.The aim of this work was to investigate the solid-state thermal stability of phenylbutazone at condition of the pelletization process (40°C; 60 min). The other aim was the preparation of phenylbutazone pellets with centrifugal granulator.Based non the flowability and the other parameters of, the pellets, they are suitable for capsule filling or tabletting. The centrifugal granulation and the conditions were favourable for the preparation of pellets from phenylbutazone in the form of needle crystals.

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Abstract  

[4−14C] phenylbutazone (4-butyl-1,2-diphenyl-3,5-[4−14C] pyrazolidinedione) has been synthesised on the 5 mmole scale. [2−14C] Diethyl malonate was reacted with n-butyl bromide and the product condensed with hydrazobenzene in the same reaction vessel. The radiochemical yield of highly purified product was 48%. It is proposed that care should be taken in analyses for metabolic products, particularly by TLC, since 4-hydroxyphenylbutazone was shown to be an oxidation product of phenylbutazone in solution and on TLC plates under quite mild conditions. A pure sample of 4-hydroxy [4−14C] phenylbutazone was isolated.

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Journal of Thermal Analysis and Calorimetry
Authors: Y. A. Ribeiro, J. D. S. de Oliveira, M. I. G. Leles, S. A. Juiz, and M. Ionashiro

Thermogravimetry, derivative thermogravimetry (TG, DTG) and differential scanning calorimetry (DSC), were used to study the thermal behaviour of mefenamic acid, ibuprofen, acetaminophen, sodium diclofenac, phenylbutazone, dipyrone and salicylamide. The results led to thermal stability data and also to the interpretation concerning the thermal decomposition.

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. Lees, P., Taylor, J. B., Higgins, A. J. and Sedgwick, A. D. (1988): In vitro and in vivo binding of phenylbutazone and related drugs to equine feeds and digesta. Res. Vet. Sci. 44 , 50-56. In vitro and in vivo binding of

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prepared aseptically distal to the fetlock joint. The contralateral limb was covered with a sterile surgical drape. The horses were positioned with both of their front feet on a 10 cm high wooden block ( Fig. 1 ). Phenylbutazone (2.2 mg/kg) and amoxicillin

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. Beretzky , Á , P Kása Jr , Pintye-Hódi , K , Bajdik , J , Szabó-Révész , P , Erős , I . Pelletization of needle-shaped phenylbutazone crystals . J Therm Anal Calorim . 2002 ; 69 : 529 – 539 . 10.1023/A:1019959722975

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treatment has been reported so far. A number of management and pharmaceutical interventions including increased exercise/turnout, diet changes, acupuncture, chiropractic, herbs, flunixin meglumine, phenylbutazone, tranquilisers, muscle relaxants and

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