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In this study, we examined the relationship between levels of lactoferrin (LF) and IL-17 in human serum and breast milk and the development of allergy in children. LF and IL-17 levels were determined by ELISA in healthy (n=19) and allergic mothers (n=21) on the 5th day after delivery. Two years later, information on breastfeeding and allergic outcomes was collected by questionnaires from parents of both groups and district child care nurses. Significantly higher concentrations of LF were found in the breast milk of allergic mothers compared to the healthy controls. At 2 years of age, only those three infants became allergic from the atopic group in whose starting breast milk samples a very high LF level (306 μg mg–1 protein) or simultaneously elevated concentrations of LF and IL-17 were measured. These findings indicate that the very early measurement of LF and IL-17 levels in the breast milk of allergic mothers may help to predict the allergy development in their infants.
Abstract
One of the frequent causes of pollen allergy in our region (Serbia, Yugoslavia) is the pollen of poplar (Populus canadensis). The aim of this study was to form RAST for the determination of specific anti-Populus canadensis IgE antibodies. Affinity purified and radiolabelled (I-125) MoAb E1 was used for forming assay for the determination of specific IgE. By titration of extract of poplarPopulus canadensis we determined that the quantity of 0.65 mL extract is needed for coupling of lg BrCN activated paper discs. Coupling was performed in Na2CO3/NaHCO3 buffer pH 10, on 4°C for 48h. Using this newely formed RAST, specific forPopulus canadensis, we have deteminated anti-Populus canadensis IgE antibodies as well as cross reactivity between pollens ofPopulus canadensis andPopulus deltoides.
Agriculture is highly affected by climate change. Climate change impacts may influence almost all fields of agricultural activities; production efficiency, quantitative and qualitative deterioration of crop yields produced for alimentary purposes, and determine post-harvest manifestation of agricultural products inducing hazard in the field of food safety, transport, storage and distribution. Soil-climatic conditions, amount and distribution of precipitation, anomalies and extremities of temperature as well as various manifestation of air movement from stand still to storms are some of the main factors that may influence agriculture. Pollution has been considered solely as the presence of unfavourable alien matter in the environment, but in reality pollution is far more than that. Agri-environmental pollution is largely independent of mankind, since many pollution or degradation processes may begin with no direct relationship to human activities. Soil degradation, or irreversible damage to natural ecosystems by climatic factors (drought, flood, water logging, salinity) are the most frequent consequences. Biological pollution, like weed infestation, epidemics and gradations, pollen allergy, the poisonous effect of mycotoxins on farm animals and humans, new pests and diseases, the emission of greenhouse gases, and biological factors which cause quality deterioration represent an increasing pressure on agri-environment. This paper is intended to give an overview of some research activities and their results in relation with climatic aspects of agri-environmental pollution in Hungary.
Absztrakt:
A pulmonalis arterialis intimalis sarcoma ritka, magas mortalitású daganat, mely lokalizációja miatt a pulmonalis embolia, valamint a tüdőgyulladás tünettanát utánozhatja. A diagnózis felállítása és a megfelelő kezelés kiválasztása körül számos kérdés merülhet fel. Egy 46 éves, korábban hereseminoma, pulmonalis embolia, asztma, valamint pollenallergia miatt kezelés alatt álló férfi kontroll mellkasi CT-felvételén bal oldalon a mediastinalis pleurát infiltráló, az arteria pulmonalist teljesen elzáró, összességében 7–8 cm-es térfoglaló folyamatot írtak le. A hörgőbiopsziás mintából orsósejtes tumor diagnózisa született, illetve leiomyoma, leiomyomatosus hyperplasia, illetve leiomyosarcoma lehetőségét vetették fel. A fennálló obstrukció miatt a beteg bal oldali tüdőeltávolításon esett át. A szövettani vizsgálat a pulmonalis artériákban terjedő, orsósejtes daganatot kórismézett, immunhisztokémiailag diffúz SMA- és fokális MDM2-pozitivitással, valamint magas proliferációs aktivitással. A h-caldesmon, az S100 protein, az ERG, valamint a pancitokeratin-immunfestések negatívnak bizonyultak. Fluoreszcens in situ hibridizációval a tumorsejtek mintegy 10%-ában polysomiát, illetve MDM2-amplifikációt lehetett igazolni, aminek alapján a „high-grade” pulmonalis arterialis intimalis sarcoma diagnózisa megerősítésre került. Féléves követés alatt a betegség nem újult ki. A pulmonalis arterialis intimalis sarcoma pontos incidenciája nem ismert. Egyes források szerint a krónikus pulmonalis hypertoniás betegek 1–4%-ánál fordul elő. A tünetek közül a fogyás kelti fel a leginkább a daganatos betegség gyanúját. A képalkotó és a kórszövettani vizsgálatoknak kulcsszerepük van a diagnózis felállításában. A daganat rossz kórjóslata miatt a minél korábbi felismerés és a kemoterápiával kombinált sebészi kezelés javíthatja a túlélési lehetőségeket. Orv Hetil. 2020; 161(6): 232–236.
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A 2019. évi ARIA kezelési irányelvek magyar adaptációja és a hazai alkalmazás lehetőségei allergiás rhinitisben
Hungarian adaptation and launch of the 2019 ARIA care pathways of allergic rhinitis in Hungary
5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018; 141: 529–538.e13
only partly cooperative, he keeps telling that he is feeling unwell. Apart from pollen allergy there is no relevant medical history. ” Based on the given details, the correct answer of sepsis/SIRS could be misdiagnosed most likely as
