Authors:X. Han, Y. Hu, Z. Lin, S. Li, F. Zhao, Z. Liu, J. Yi, L. Zhang, and X. Ren
Effects of fullerenes including FS, EFS and pure C60 on thermal behaviors of polyethylene glycol (PEG) have been studied by employing thermogravimetry-differential thermogravimetry
(TG-DTG), differential scanning calorimeter (DSC) and off-line furnace-type pyrolysis-gas chromatography/mass spectrometry
(Py-GC/MS). The products were collected by Cambridge filter pad which was widely used in analyzing the combustion products
of cigarette. The results showed that the addition of fullerenes obviously restrained the thermal decomposition of PEG. The
initial decomposition temperatures (IDT) and maximum decomposition peak temperatures (MDT) were evidently postponed by the
addition of fullerenes. Pyrolysis products with one or two hydroxyl end groups obviously increased with the addition of 10%
C60. The reasons of the changes were discussed from the aspects of reaction mechanisms.
Solid dispersions of the antidiabetic drug glibenclamide and polyethylene glycol 4000 (macrogol 4000) were prepared by the
melting method in order to increase the solubility of this poorly water-soluble compound. The temperature/composition phase
diagram of the components was analyzed by hot-stage microscopy and differential scanning calorimetry, showing a monotectic.
Polarized light hot stage microscopy and X-ray-powder diffraction confirmed, that glibenclamide is mainly present in a non-crystalline
state after melting and solidifying of a 10% (w/w) mixture, which results in an enhanced solubility compared to physical mixtures. The solubility and dissolution rate of the
drug increases clearly with decreasing drug/polymer ratio. Moreover, it was observed for the first time that a drug could
crystallize as whiskers at the surface of aged solid dispersion particles. Besides relaxation phenomena, this crystallization
mechanism may be responsible for a deterioration of liberation properties and bioavailability of solid dispersion based drug
products with increasing storage time.
Authors:Venkata Ramana Malipeddi, Rajendra Awasthi, and Kamal Dua
with varying concentrations of a mixture of two polymers: a water-insoluble polymer, ethylcellulose (EC), and a water-soluble polymer, polyethyleneglycol-6000 (PEG-6000).
EC, if used alone, a hydrophobic water-impermeable matrix would be formed
Authors:J. Rais, P. Selucký, M. Kyrš, and L. Kadlecová
The extraction of cesium and barium cations into nitrobenzene and 60% (vol.%) nitrobenzene +40% CCl4 mixture in the presence of dicarbollide (+Slovafol 909), and primary alkylammonium cations has been studied. Extraction constants determined for three methylammonium cations correlate well with their hydration enthalpies. Reverse order of the hydrophobicity of methylammonium cations (competition with bare Cs+ ion) and of their tendency to enter the polyethylene glycol complex (competition with polyethylene glycol complexed Cs+ and Ba2+ ions) is recorded. The possibility of the regeneration of the organic phase after stripping of Cs+ and Ba2+ ions with methylammonium cations has been investigated.
Authors:Jie Chen, Young Nho, Oh Kwon, and A. Hoffman
Polyethylene glycol methacrylate (PEGMA) with different polyethylene oxide units were grafted onto polypropylene (PP) films
by a preirradiation grafting method. The effect of co-solvent system on the degree of grafting and water contact angle were
determined, respectively. The grafted sample films were verified by Fourier Transform Infrared (FTIR) spectroscopy in the
attenuated total reflectance mode (ATR). The biocompatibility and blood compatibility of the grafted PP films were evaluated
by the determination of protein adsorption, platelet adsorption and thrombus.
A new polyethylene glycol supported chiral monosulfonamide was conveniently synthesized from (R,R)-1,2-diphenylethylenediamine. The ruthenium catalyst prepared from polyethylene glycol supported chiral monosulfonamide with
[RuCl2(p-cymene)]2 was used in the asymmetric transfer hydrogenation of prochiral ketones in neat water with good to excellent conversions and
enantioselectivities. The catalyst could be easily recovered and reused several times.
Authors:J. Suñol, J. Farjas, R. Berlanga, and J. Saurina
A modified isoconversional method is applied to perform the kinetic analysis of non-isothermal processes. The solidification
process of a polyethylene glycol with a mean molecular of 4000 (PEG 4000) was here analyzed. It was stated that the Avrami
model provides a good description of the solidification process.
Temperature-cooling rate-transformation diagrams were constructed and there was a good agreement between experimental data
and the calculated T-CR-T curves. Moreover, morphological qualitative analysis has been performed by means of scanning electron
The extraction of strontium and cesium ions from high ionic strength acid, base, and salt solutions into an organic extractant
consisting of alkyl cobalt dicarbollide and polyethylene glycol (PEG) in diethylbenzene was investigated. Adding hexaethylene
glycol or PEG-400 improved the strontium extraction ≥100-fold, while cesium extraction was decreased at high PEG concentrations.
The extractions are rapid and selective, even in the presence of molar concentrations of sodium ion, suggesting that alkyl
cobalt dicarbollide extractants are useful for the treatment of alkaline nuclear wastes. A method for the synthesis of tetra-n-hexyl(cobalt dicarbollide) is described.