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receptor function is affected by the presence of various genetic polymorphisms [ 26 ]. Several polymorphisms have been identified in the introns and exons of the VDR gene. These include Tru9I and BsmI on intron 8, FokI on exon 2 and Taq I on exon 9 [ 33

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Abstract  

Terfenadine samples prepared by crystallization in different media and supersaturation conditions were used to investigate the polymorphism of the substance. The study was based on DSC melting curves. An empirical parametric equation was used for modelling the experimental data. The signal recorded was resolved into the corresponding overlapping peak components by fitting analysis. Four polymorphic phases were identified.

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Polymorphism of paracetamol

Relative stability of the monoclinic and orthorhombic phase revisited by sublimation and solution calorimetry

Journal of Thermal Analysis and Calorimetry
Authors: G. Perlovich, Tatyana Volkova, and Annette Bauer-Brandl

Abstract  

The thermodynamic relationship between crystal modifications of paracetamol was studied by alternative methods. Temperature dependence of saturated vapor pressure for polymorphic modifications of the drug paracetamol (acetaminophen) was mea sured and thermodynamic functions of the sublimation process calculated. Solution calorimetry was carried out for the two modifications in the same solvent. Thermodynamic parameters for sublimation for form I (monoclinic) were found: ΔG sub 298=60.0 kJ mol−1; ΔH sub 298=117.9�0.7 kJ mol−1; ΔS sub 298=190�2 J mol−1 K−1. For the orthorhombic modification (form II), the saturated vapor pressure could only be studied at 391 K. Phase transition enthalpy at 298 K, ΔH tr 298(I→II)=2.0�0.4 kJ mol−1, was derived as the difference between the solution enthalpies of the noted polymorphs in the same solution (methanol). Based on ΔH tr 298 (I→II), differences between temperature dependencies of heat capacities of both modifications and the vapor pressure value of form II at 391 K, the temperature dependence of saturated vapor pressure and thermodynamic sublimation parameters for modification II were also estimated (ΔG sub 298=56.1 kJ mol−1; ΔH sub 298=115.9�0.9 kJ mol−1; ΔS sub 298=200�3 J mol−1 K−1). The results indicate that the modifications are monotropically related, which is in contrast to findings recently reported found by classical thermochemical methods.

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O, Yang F, Tsai MY: C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease. Clin. Chem. 47, 661–666 (2001

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locus for obesity. The genetic variants of FTO gene were found to be significantly associated with obesity in diverse populations [ 17–21 ]. To the best of our knowledge, there is only one report regarding the impact of FTO gene polymorphisms

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. Biagini A. Clerico 2003 Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease Clin Chem

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-Lynch, F., Adams, C., Amos, C., Zhu, D. K., McDermott, M. F., Shanahan, F., Molloy, M. G., O'Gara, F.: Tumour necrosis factor 5' promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis in immunogenetically defined multiplex

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Interventional Medicine and Applied Science
Authors: Mojgan Karimi-Zarchi, Mansour Moghimi, Hajar Abbasi, Amaneh Hadadan, Razieh-Sadat Tabatabaei, Atiyeh Javaheri, and Hossein Neamatzadeh

.3 [ 13 ]. It is involved in the homologous recombination repair (HR) pathway, responsible for DNA double-strand breaks [ 14 ]. XRCC3 is a polymorphic gene where many SNPs have been already described. Several polymorphisms in the XRCC3 gene have been

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Interventional Medicine and Applied Science
Authors: Mojgan Karimi-Zarchi, Mansour Moghimi, Hajar Abbasi, Amaneh Hadadan, Razieh-Sadat Tabatabaei, Atiyeh Javaheri, and Hossein Neamatzadeh

.3 [ 13 ]. It is involved in the homologous recombination repair (HR) pathway, responsible for DNA double-strand breaks [ 14 ]. XRCC3 is a polymorphic gene where many SNPs have been already described. Several polymorphisms in the XRCC3 gene have been

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Battistuzzi G, Petrucci R, Silvagni L, Urbani FR, Caiola S: δ-Aminolevulinate dehydrase: a new genetic polymorphism in man. Ann. Hum. Genet. 45, 223–229 (1981) Caiola S δ

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