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Introduction Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the main psychoactive, naturally occurring alkaloid in over 200 species of mushrooms worldwide. As the prodrug of psilocin (4-OH-dimethyltryptamine), these compounds act in

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Journal of Psychedelic Studies
Authors: Henrik Børsting Jacobsen, Audun Stubhaug, Bjørn Holmøy, Tor Morten Kvam, and Silje Endresen Reme

Introduction Psilocybin, or 4-phosphoryloxy-N,N-dimethyltryptamine, is a hallucinogenic compound that is one of a few active constituents contained in a variety of mushrooms, most in the family psilocybe, referred to as “magic mushrooms”. In recent

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Journal of Psychedelic Studies
Authors: Kelley C. O’Donnell, Sarah E. Mennenga, and Michael P. Bogenschutz

Introduction Although clinical research on classic psychedelics [e.g., psilocybin, lysergic acid diethylamide (LSD), and ayahuasca] dates back almost 70 years, its current iteration is relatively new. The number of groups

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Introduction The last decade has witnessed a resurgence of interest in serotonergic psychedelics, such as lysergic acid diethylamide (LSD) and psilocybin, for the treatment of a range of psychopathologies. Whilst individuals self-medicate with

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Introduction Studies suggest that the psychedelic compound psilocybin may be an effective treatment for a variety of clinical issues, including treatment-resistant depression ( Roseman, Nutt, & Carhart-Harris, 2018 ), anxiety and depression related

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Introduction Hallucinogens, primarily lysergic acid diethylamide (LSD) and psilocybin, have been used for the treatment of anxiety and mood disturbance associated with terminal illnesses since as early as 1960, with four

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during the highest intensity hours of a psilocybin session, but begin discussing the patients experience before the effects of the psychedelic compound have completely worn off. Both psychedelic-assisted and psycholytic psychotherapy are designed

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-addictive, and exerting profound effects on human consciousness. Examples of classical psychedelics include DMT, LSD, psilocybin, mescaline, and compounds of the 2C family. The tryptamine psychedelics such as DMT and psilocybin structurally resemble serotonin

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intentionally ingest psilocybin in Mexico” as well as the only author of the book Mushrooms, Russia, and History ( Wasson & Wasson, 1957 ). In fact, Gordon Wasson's wife, Dr. Valentina “Tina” Pavlovna Wasson, had as much if not more influence in bringing the

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participants in a two-session psilocybin trial met criteria for remission ( Carhart-Harris et al., 2018 ), a rate comparable to that of placebos ( Kirsch, 2019 ). Ketamine infusions improve mood and other symptoms almost immediately, and benefits remain at day

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