., Kordzaia, D., Dzidziguri, D. (2009) Biliary hypertension as the cell proliferation trigger in bile duct ligated rats. Georgian Med. News 111–116.
Benedetti, A., Bassotti, C., Rapino, K., Marucci, L., Jezequel, A. M
, there is increased risk of hypertension in women possessing high plasma testosterone levels as in polycystic ovary disease ( 3 , 12 ).
The effects of testosterone on blood pressure regulation have been documented in animals. In hypertensive rats
male Sprague Dawley rats aged 3–4 months and weighing between 150 and 180 g were maintained at room temperature at Nile Center for Experimental Research and had free access to food (standard pellet diet) and tap water ad libitum . This study was
In rats with diabetes induced at weaning, pathological examinations have shown that the reduction of myelin thickness occurs earlier than axon size reduction. The aim of this study was to provide a detailed description of neurophysiological changes during nerve growth and maturation in rats with streptozotocin-induced diabetes in prepubertal stage. Five-day male Wistar rats received an injection of streptozotocin. Motor and sensory conduction velocities increased until 6.5 months in diabetic and control rats and at this age it became lower in diabetic rats. In diabetic rats, the amplitudes of the compound motor action potentials (CMAP) were lower by the 3 months and did not increase later. The amplitudes and areas of sensory action potentials (SNAP) increased until 9 months in both groups. SNAP duration decreased with ageing. Sensory peak 1 and peak 2 latencies became longer from 6.5 to 9 months in diabetic rats, with a longer latency difference between the 2 sensory peaks by 4 months. At 3 and 4 months of age, peak 1 and peak 2 latencies correlated with SNAP amplitude and duration in control rats but not in diabetic rats. In conclusion, in rats with early induced diabetes, the earliest electrophysiological impairments consist of lower CMAP amplitudes, and longer difference between latencies of sensory peaks 1 and 2. These sequential neurophysiological changes should be considered when testing new therapeutic approaches in diabetic neuropathy.
accompanied by increased levels of adenosine ( 10 , 35 ). This study assessed the in vivo glycemic response of T1DM rats made hypoglycemic by insulin injection, as well as their liver gluconeogenic activity, in the presence of exercise, and/or caffeine. The
Aronia melanocarpa fruit juice (AMFJ) is rich in phenolic substances, mainly flavonoids and tannins. The influence of AMFJ (5 and 10 ml kg−1) on the gastrointestinal propulsion of charcoal meal in rats was investigated. AMFJ dose-dependently reduced the rate of intestinal transit and the effect was statistically significant at the dose of 10 ml kg−1. This reduction of the intestinal transit rate might be due to the the presence of flavonoids and tannins in the juice.
The main bioactive substances in Aronia melanocarpa fruit juice (AMFJ) are polyphenols (flavonoids, procyanidins, and phenolic acids). A great number of polyphenols are able to traverse the blood-brain barrier. In recent years more attention is drawn to the ability of these substances to influence central nervous system functions. The aim of the present study was to investigate the effects of AMFJ on exploratory behaviour and locomotor activity in male Wistar rats. AMFJ was administered orally for 7, 14, 21, and 30 days at three increasing doses (2.5, 5, and 10 ml kg−1). The changes in exploratory behaviour and locomotor activity were recorded in an Opto Varimex apparatus. It was found that the low doses of AMFJ (2.5 and 5 ml kg−1) for all treatment periods did not significantly affect exploratory behaviour and locomotor activity of rats compared to the saline-treated controls. AMFJ at the highest dose of 10 ml kg−1 had no significant effect on exploration and locomotion for the treatment periods of 7 and 14 days, while for the periods of 21 and 30 days it significantly decreased the number of horizontal and vertical movements, which might be the result of a sedative effect. At all the doses and testing periods, AMFJ did not disturb the progressive decrease in motor behaviour, suggesting habituation.