Search Results

You are looking at 1 - 10 of 46 items for :

  • "reference range" x
Clear All

Absztrakt:

Bevezetés: Korábbi kísérletek és klinikai megfigyelések alapján a pajzsmirigyhormonok szerepet játszhatnak a prosztatarák kialakulásában. Célkitűzés: Retrospektív adatelemzésünk során a pajzsmirigy-stimuláló hormon (TSH) és a prosztataspecifikus antigén (PSA) vérszintjei közötti kapcsolatot értékeltük a Semmelweis Egyetem Laboratóriumi Medicina Intézetében az elmúlt 12 évben mért TSH- és PSA-szintek alapján. Módszer: A laboratóriumi informatikai rendszerből lekértük azon, 40 és 75 éves kor közötti férfi betegek TSH- és PSA-értékeit, akiknél a két mérés között legfeljebb 14 nap telt el (n = 7279). A logaritmizált TSH- és PSA-szintek közti kapcsolatot többszörös regresszióval értékeltük, és a betegek életkorára korrigáltuk. Eredmények: Az lnPSA és lnTSH, valamint az lnPSA és az életkor között szignifikáns kapcsolatot találtunk (r = 0,297, illetve 0,472). A hyperthyreoticus (TSH<0,35 mU/ml) (n = 405) és euthyreoticus (TSH 0,35–4,95 mU/ml) (n = 6698) betegek PSA-szintjei szignifikánsan különböztek, alacsonyabb TSH esetén magasabb volt a PSA-szint (1,118 [0,639–2,338] vs. 0,920 [0,508–1,826] ng/ml, p<0,016). A regressziós elemzés alapján a TSH 10%-os csökkenése esetén a vizsgált populációban 0,42%-kal nő a PSA-szint. Ez azt jelenti, hogy ha egy betegnél a 2,0 mU/ml TSH-szint 0,2 mU/ml-re csökken, akkor a PSA-értéke 42%-kal emelkedne. Következtetés: Eredményeink arra utalnak, hogy a PSA-szint egészséges referenciatartománya hyperthyreoticus és euthyreoticus betegek között eltér. Javasolt, hogy a PSA klinikai vágóértékét a laboratóriumok a beteg pajzsmirigystatusa alapján módosítsák. Orv Hetil. 2019; 160(35): 1376–1379.

Open access

.: Abbott Diagnostic Educational Servi European Evolutions. Kiadói példány, 1999. Soldin, S. J.: Pediatrics reference ranges. AACC Press, 1999. Hicks, J. M

Restricted access
Acta Veterinaria Hungarica
Authors: Beáta Török-Nagy, Péter Vajdovich, Lajos Balogh, Julianna Thuróczy and Béla Dénes

Ltd.). Statistical analysis of the results The reference range was set up on the basis of the measurement results of samples from dogs judged to be healthy. This group had normal distribution, as proved by the Shapiro–Wilk test. The P value was 0

Open access
Physiology International
Authors: M Zdravkovic, B Milovanovic, S Hinic, I Soldatovic, T Durmic, G Koracevic, S Prijic, O Markovic, B Filipovic and D Lovic

, although still in normal reference range, were significantly higher in athletes compared with the control group. Also, there was a statistically significant correlation between all these parameters and QTc interval duration ( p  < 0.01). Concerning

Restricted access

The aim of this study was to determine the reference range of Schirmer tear test (STT) values in sheep using Greek indigenous and mixed breeds and to investigate the potential effect of breed and season on these values. Ninety (30 Chios, 30 Florina and 30 Lacaune mixed breed) ewes aged 2 years or more were used for the study. The aqueous portion of the tear film was measured using Schirmer tear test (STT) commercial strips bilaterally by the same investigator with the animal in standing position. The average STT value recorded was 18.45 ± 3.93 mm/min and the range 10.8–26.2 mm/min. STT was significantly affected by the season and the recorded values were significantly higher in summer compared to winter. The breed had no significant effect on tear secretion. The results of the present study provide a reference range of STT values in sheep and indicate that tear secretion is significantly affected by the season.

Restricted access

Abstract  

In this study, bromine (Br), chlorine (Cl), potassium (K) and sodium (Na) were measured in the blood of Brazilian inhabitants from Southeast (S) and Northeast (N) regions. A reference range was established as a function of sex and considering lifestyle factors (non-smokers and non- drinkers). For both regions lower values of K were found in females when compared to males and lower values of Na were found in males compared to females. Increasing trends for Na and Br were observed in the Northeast region.

Restricted access
Acta Veterinaria Hungarica
Authors: Sándor Hornok, Marina Meli, Enikő Gönczi, Éva Ignits, Barbara Willi, Hans Lutz and Regina Hofmann-Lehmann

Although haemobartonellosis was previously reported in Hungary, until now the diagnosis (based on morphological identification in blood smears) has only been suggestive of the occurrence of the large species, recently reclassified as Mycoplasma haemofelis . However, in July 2007 a cat was presented at a small animal clinic with severe haemolytic anaemia, icterus and haemoglobinuria. While biochemical parameters were within the reference range, the cat had leukocytosis and rapidly decreasing haematocrit values, and eventually died 7 days after the sudden onset of aggravating clinical signs. From blood samples of the cat ‘ Candidatus Mycoplasma haemominutum’ was identified by molecular methods, according to its 100% 16S rRNA gene sequence homology with two Swiss isolates and one isolate from the UK. The rapid termination of the disease and the high pathogenicity of the causative agent observed in this case are unusual, taking into account that PCR results were negative for immunosuppressive viruses. This is the first record of this feline haemoplasma species in Hungary.

Restricted access
Acta Alimentaria
Authors: M. Antal, A. Regöly-Mérei, L. Biró, K. Nagy, J. Fülöp, E. Beretvás, E. Gyömörei, O. Kis and A. Vámos

This study investigates the nutritional status, life-style practices, serum vitamin D and bone density of adolescents. A total of 326 adolescents, aged between 11 and 14 years, were involved in the present examination: after winter 110 boys and 97 girls (March 2002 and February 2003), and after summer 66 boys and 53 girls (October 2002 and 2003) were investigated. Energy and nutrient intake and life-style practices were assessed. Body mass and height were measured, body mass index was calculated. Serum concentration of 25-hydroxyvitamin D [25(OH)D] was determined. Bone mineral density of calcaneus was measured. Protein intake was higher than the Hungarian RDA. All of the students had vitamin D intake far below the RDA, 33.3% of boys and 43.2% of girls had Ca intake below 70% of RDA, and sodium intake was more than twice higher than the RDA. After winter, 2% of boys and 8% of girls were considered vitamin D deficient and 11% and 19% vitamin D insufficient, respectively. After summer, 24% of boys and 21% of girls had 25(OH)D level over the reference range. The mineral content of bone was insufficient in 12.9% of boys and 10.4% of girls, respectively. The majority of the students had physical activity only in school, incorporated in the timetable.

Restricted access

Plasma homocysteine and Cystatin C levels of 360 chronic haemodialysed patients were measured in fasting (191 men, mean age: 55.5 years; and 169 women, mean: 62.9 years). The patients were divided into subgroups: diabetes mellitus (34 men and 38 women 7 vs 8 IDDM). obliterative arteriosclerosis (68 men and 61 women), cardiovascular complications (75 men and 84 women) and stroke (16 men and 12 women), and after renal transplantation in chronic rejection (15 men and 5 female). Homocysteine was determined by IMx analyser from Abbott by FPIA method. Immunoturbidimetric method was used for quantification of Cystatin C (PETIA). The lowest Cystatin C concentration was found in diabetic patients (4.35±0.15 mg/l in men and 3.18±1.77 mg/l in women) and the highest one occurred in anuric and bilateral nephrectomised and transplanted chronic rejected patients (6.075 mg/l in men and 6.35 mg/l in women: p<0.001). The homocysteine levels (24.98±2.94mmol/l in men and 23.88±1.76mmol/l in women) exceeded the upper limit of reference range (<15.0mmol/l). There was a significant difference in favour of subgroup of cardiovascular (27.25mmol/l in men and 26.87mmol/1 in women) and stroke patients (27.16mmol/l in men and 30.76mmol/l in women p<0.001). Elevated levels were found in chronic rejected patients with accelerated arteriosclerotic events (25.94mmol/l in men and 27.43mmol/l in women). Good positive linear correlation was found between serum homocysteine and Cystatin C levels (r=0.2393 and 0.2252). The authors demonstrated hyperhomocysteinaemia associated with high Cystatin C concentration in four subgroups of haemodialysed patients (obliterative and accelerated arteriosclerosis. cardiovascular disease, and cerebrovascular complications and stroke).

Restricted access
Orvosi Hetilap
Authors: V. Oláh Anna, János Mátyus, Erika Sárkány, Andrea Horváth and Bertalan Fodor

Újabb klinikai vizsgálatok szerint az albuminuria a cardiovascularis betegségek korai markere. Míg a proteinuria elsősorban a vesefunkció-romlás, az albuminuria a cardiovascularis rizikó paramétere. A régebbi laboratóriumi tesztek érzékenysége nem megfelelő, és a 24 órás vizeletgyűjtés pontatlansága is sok bizonytalanságot okoz. Ezért a mai nemzetközi irányelvek 24 órás gyűjtés helyett a reggeli első vizeletből az albumin/kreatinin (ACR) és protein/kreatinin (PCR) meghatározását javasolják. Klinikai laboratóriumok számára javasolhatók az újabb, nagy érzékenységű immunkémiai vizeletalbumin-reagensek. Az albuminspecifikus tesztcsíkok az albuminuria fokának meghatározására nem elég érzékenyek. A vizeletfehérje-meghatározáshoz szintén léteznek nagy érzékenységű, széles mérési tartományú reagensek, így erre nem alkalmazhatók a szérumfehérje-reagensek (például Biuret). A módszerválasztás sarkalatos pontja, hogy a kalibrátor nemzetközi referensanyagra visszavezethető legyen. Mindezekből következik, hogy egy beteg ACR- vagy PCR-értéke az adott módszert és döntési határértéket alkalmazó ugyanazon laboratóriumban követhető jól. A laboratóriumi leleten az albumin/kreatinin referenciatartományát nemenként kell megadni.

Restricted access