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Cohen, S. B., Emery, P., Greenwald, M. W. és mtsai:
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a
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CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med., 2002,
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Rituximab was successively labeled with [67Ga]-gallium chloride after residulation with freshly prepared cyclic DTPA-dianhydride. The best results of the conjugation
were obtained by the addition of 1 ml of a rituximab pharmaceutical solution (5 mg/ml, in phosphate buffer, pH 8) to a glass
tube pre-coated with DTPA-dianhydride (0.01 mg) at 25 °C with continuous mild stirring for 30 minutes. Radio thin-layer chromatography
showed an overall radiochemical purity of 96–99% at optimized conditions (specific activity = 300–500 MBq/mg, labeling efficiency
77%). The final isotonic 67Ga-DTPA-rituximab complex was checked by gel electrophoresis for radiolysis control. Radio-TLC was performed to ensure the
formation of only one species, followed by filtration through a 0.22 μm filter. Preliminary in vivo studies in normal rat
model was performed to determine the biodistribution of the radioimmunoconjugate up to 6 hours.
Schulz, H., Bohlius, J. F., Trelle, S. és mtsai:
Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis. J. Natl. Cancer. Inst., 2007,
.: Clinical value of minor responses after 4 doses of rituximab in Waldenström macroglobulinaemia: a follow-up of the Eastern Cooperative Oncology Group E3A98 trial. Br. J. Haematol., 2009, 147 , 677–680.
Heffner L. T