Authors:Orsolya Kiss, Anna-Mária Tőkés, Sándor Spisák, Anna Szilágyi, Norbert Lippai, A. Marcell Szász and Janina Kulka
Reyes, C., Jorda, M., Gomez-Fernandez, C.: Salivarygland-like tumors of the breast express basal-type immunohistochemical markers. Appl. Immunohistochem. Mol. Morphol., 2012 Aug 29. [Epub ahead of print]
lesions to the oral mucosa [ 1 ]. The most frequently reported complaint related to medication usage is salivation dysfunction, and specifically dry mouth sensation. Salivation is defined as the secretion of fluids by the salivaryglands, and is essential
Authors:Yevhen V. Kuzenko, Anatoly M. Romanuk, Olena Olegivna Dyachenko and Olena Hudymenko
Papillary cyst adenolymphoma is the second most common benign cystic tumor of the salivarygland. This tumor was first described by Hilderbrand in 1895 as a form of congenital cyst of
Gamma-ray transmission tomography and neutron induced gamma-ray emission tomography (NIGET) where delayed gamma-rays from an activated sample are detected in a tomographic mode, were used to investigate the elemental composition and distribution of a salivary gland stone, nondestructively. Transmission tomography provided information about the distribution of the linear photon attenuation coefficient in the object and showed clearly the two regions of inorganic and organic material in a number of sections through it. In addition it was possible to derive from the data the concentration of Ca and the ratio of Ca to P in the stone. By using NIGET it was shown that the concentration of Ca and Na in the object can be mapped and quantitative measurements of these elements could be obtained in any particular location within the salivary gland stone. The spatial resolution which depends on detector collimation was 1 mm for transimission and 2 mm for emission measurements. Instrumental neutron activation analysis was also used to determine the concentration of five elements in the stone, as a whole.
Authors:Omar Kujan, Abdulwahab Abuderman and Ahmad Zahi Al-Shawaf
Fragile histidine triad (FHIT) is a tumor suppressor gene that is commonly inactivated in human tumors. Interestingly, the normal pattern of FHIT expression is largely unknown.
This study is aimed to characterize the expression of FHIT protein in normal human tissues.
Materials and methods
A total of 119 normal human tissue specimens were analyzed for the FHIT expression using immunohistochemistry technique. The inclusion criteria included: normal/inflammatory tissue with no evidence of cellular atypia.
All studied specimens were stained positively with FHIT and showed either nuclear or cytoplasmic expression. Interestingly, the pattern of FHIT staining was similar among different specimens from each organ. FHIT is located predominantly in the nucleus, although cytoplasmic staining is also present in some cell types. Oral squamous epithelium, breast ductal epithelium, squamous and tubal metaplastic epithelium of the uterine cervix, esophageal squamous epithelium, salivary glands, and bronchial epithelia all strongly expressed the nuclear protein. In connective tissue, FHIT has shown strong cytoplasmic expression in histocytes including macrophages and dendritic cells, fibroblasts, and myofibroblasts.
Documentation of the pattern of FHIT expression in normal tissues will contribute to our understanding of the normal function of this protein and to interpretation of potentially altered FHIT expression in human tumors.