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The thermal behaviour of salicylsalicylic acid (CAS number 552-94-3) was studied by differential scanning calorimetry (DSC). The endothermic melting peak and the fingerprint of the glass transition were characterised at a heating rate of 10C min-1. The melting peak showed an onset at T on = 144C (417 K) and a maximum intensity at T max = 152C (425 K), while the onset of the glass transition signal was at T on = 6C. The melting enthalpy was found to be ΔmH = 28.90.3 kJ mol-1, and the heat capacity jump at the glass transition was ΔC P = 108.10.1 J K-1mol-1. The study of the influence of the heating rate on the temperature location of the glass transition signal by DSC, allowed the determination of the activation energy at the glass transition temperature (245 kJ mol-1), and the calculation of the fragility index of salicyl salicylate (m = 45). Finally, the standard molar enthalpy of formation of crystalline monoclinic salicylsalicylic acid at T = 298.15 K, was determined as ΔfHm o(C14H10O5, cr) = - (837.63.3) kJ mol-1, by combustion calorimetry.

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) Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans. Semin. Arthritis Rheum. 20 , 121–127. Elta G. H

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Journal of Thermal Analysis and Calorimetry
Authors: José Valdilânio Virgulino Procópio, Valmir Gomes de Souza, Rodrigo Albuquerque da Costa, Lidiane Pinto Correia, Fábio Santos de Souza, and Rui Oliveira Macêdo

simultaneous TG–DTA study of the thermal decomposition of 2-hydroxybenzoic acid, 2-carboxyphenyl ester (salsalate) . Thermochim Acta 410 : 15 – 21 10.1016/S0040-6031(03)00370-8 . 7. Chawla , G

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, Choi KM : Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A . Biochem. Pharmacol. 86 , 960 – 969 ( 2013 ) 10.1016/j.bcp.2013.07.034 23

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