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Abstract  

Oxamniquine (OXA) is a schistosomicide agent that causes some adverse effects in central nervous system. Intending to improve OXA therapeutic properties, a polymeric prodrug was designed. Currently, there is an increasing interest of thermal analytical techniques in the pharmaceutical area, so differential thermal analysis (DTA) and thermogravimetry (TG) were carried out to evaluate the thermal behavior of OXA, polymethacrylic acid (PMA), [poly(methacrylic-co-oxamniquine methacrylate)acid] (PMOXA) and physical mixture (OXA+PMA). The thermoanalytical profile of the physical mixture showed characteristic events of the thermal decomposition of OXA and PMA. Distinctly, PMOXA DTA curve did not show an endothermic peak at 148.5C indicating that the drug was incorporated into the polymeric system. These results were corroborated by the IR spectroscopy and X-ray diffraction data.

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. Brooker , S. , Kabatereine , N. B. , Gyapong , J. O. , Stothard , J. R. , Utzinger , J. ( 2009 ) Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa . Parasitol. 136

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Orvosi Hetilap
Authors: Alexandra Juhász, Ádám Dán, Béla Dénes, István Kucsera, József Danka, and Gábor Majoros

–23. 20 Lambertucci, J. R.: Acute schistosomiasis mansoni: revisited and reconsidered. Mem. Inst. Oswaldo Cruz, 2010, 105 (4), 422–435. 21

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Abstract  

The impact of 17 year period of funding in schistosomiasis research on publication outcome was examined. Two productivity and three quality indicators were used to compare the output from the entire population of schistosomiasis in this period with those associated with 351 funded researchers. A substantially higher productivity and citation impact were found. This consistency of direction points to the positive effect of a period of sustained funding commitment.

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Journal of Thermal Analysis and Calorimetry
Authors: Ana Luiza Ribeiro de Souza, Tatiana Andreani, Fernando M. Nunes, Douglas Lopes Cassimiro, Adélia Emília de Almeida, Clóvis Augusto Ribeiro, Victor Hugo Vitorino Sarmento, Maria Palmira Daflon Gremião, Amélia M. Silva, and Eliana B. Souto

schistosomiasis, as well as in other fluke infections that are pathogenic to humans [ 1 ]. After oral administration, PZQ suffers a rapid and nearly complete absorption, to a significant first-pass effect, of liver metabolism and kidney elimination [ 2 ]. PZQ

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References Agrawal , M. ( 2012 ): Schistosomes and schistosomiasis in South Asia . Springer (India) Pvt. Ltd. , New Delhi . pp. 101 – 112

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European Journal of Microbiology and Immunology
Authors: Z. Dakić, A. Nikolić, L. Lavadinović, M. Pelemiš, I. Klun, O. Dulović, B. Milošević, G. Stevanović, I. Ofori-Belić, J. Poluga, Olgica Djurković-Djaković, and M. Pavlović

, Ejov M , Joergensen P : Malaria in the WHO European Region ( 1971–1999 ) Euro Surveill 6 , pii=213 (2001). 4. Jelinek T : Imported schistosomiasis in Europe

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Journal of Thermal Analysis and Calorimetry
Authors: Adelia Emilia de Almeida, Ana Luiza Ribeiro Souza, Douglas Lopes Cassimiro, Maria Palmira Daflon Gremião, Clóvis Augusto Ribeiro, and Marisa Spirandeli Crespi

Introduction Schistosomiasis is a group of parasitic diseases caused by the species of trematodes, a helminths belonging to the genus Schistosoma . It is estimated that around two hundred million people are affected by

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Posey, D. L., Blackburn, B. G., Weinberg, M., et al.: High prevalence and presumptive treatment of schistosomiasis and strongyloidiasis among African refugees. Clin. Infect. Dis., 2007, 45 (10

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