Biology of Heat ShockProteins (HSPs)
In 1962, Feruccio Ritossa ( 94 ) described puffiness in Drosophila salivary chromosomes and changes in gene expression in response to heat. This serendipitous finding was followed 12
new antirheumatic drugs or develop a new strategy in the treatment of RA in combination with MTX.
Heat shockproteins (HSPs) constitute a chaperone-conserved protein family that plays important roles in refolding of protein misfolding under