Authors:Igor Rabelo de França, Daniela Meneses-Santos, Gabriela Virginia Moreira, Fábio Bessa Lima, Carla Roberta de Oliveira Carvalho, and Anderson Carlos Marçal
molecular adjustments in the level and/or degree of phosphorylation of proteins involved in the intracellular insulin receptor/insulin-like growth factor receptor (IR/IGF1R) signalingpathway [ 10 – 15 ].
Proteins located downstream of the IR/IGF1
with luteolin ameliorates retinal apoptosis in diabetic retinopathy rats by regulating the NLRP1/NLRP3/ NOX4 signallingpathway. Thus, luteolin could be used clinically for the management of diabetic retinopathy. Ethics approval and consent to
Authors:SB Zanjani, L Chodari, FM Bavil, P Sadeghzadeh, and P Shahabi
Among dozens of molecular mediators related to angiogenesis, protein kinase B (AKT) and extracellular signal-regulated kinase (ERK 1/2) signalingpathways are significant as they control proliferation and survival of endothelial cells. There are
Ceppi M, Pereira PM, Dunand-Sauthier I, Barras E, Reith W, Santos MA, Pierre P: MicroRNA-155 modulates the interleukin-1 signalingpathway in activated human monocyte-derived dendritic cells. Proc
Authors:Soheil Biglari, Alireza Ghardashi Afousi, Farnoosh Mafi, and Fatemeh Shabkhiz
pathway leads to hypertrophy [ 2 ]; one of the main factors in this signalingpathway is IGF-I, which stimulates muscle fiber growth by activating an intracellular cascade [ 3 ]. In addition, the IGF-I/Akt pathway can inhibit translocation of the forkhead
Haluska, F. G., Tsao, H., Wu, H., et al.: Genetic alterations in signalingpathways in melanoma. Clin. Cancer Res., 2006, 12 (7 Pt 2), 2301s–2307s.
Lang, J., Boxer, M., MacKie, R.: Absence of exon 15 BRAF germline
reported as a general metabolic regulator ( 29 ). In addition, Wnt plays a critical role in modulations of cell growth, apoptosis, and in the process of gene expression of cell self-renewal ( 72 ).
There are many signalpathways involved in an