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Genetic effects that contribute to the risk of developing chronic obstructive pulmonary disease (COPD) have been reported. Our purpose was to estimate the possible genetic influence on CT features related to COPD in twins.

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Abstract

Introduction

It is well known that mitral stenosis (MS) is complicated by pulmonary hypertension (PH) of varying degrees. The hemodynamic derangement is associated with structural changes in the pulmonary vessels and parenchyma and also functional derangements. This article analyzes the pulmonary function derangements in 25 patients with isolated/predominant mitral stenosis of varying severity.

Aims

The aim of the study was to correlate the pulmonary function test (PFT) derangements (done by simple methods) with: a) patient demographics and clinical profile, b) severity of the mitral stenosis, and c) severity of pulmonary artery hypertension (PAH) and d) to evaluate its significance in preoperative assessment.

Subjects and Methods

This cross-sectional study was conducted in 25 patients with mitral stenosis who were selected for mitral valve (MV) surgery. The patients were evaluated for clinical class, echocardiographic severity of mitral stenosis and pulmonary hypertension, and with simple methods of assessment of pulmonary function with spirometry and blood gas analysis. The diagnosis and classification were made on standardized criteria. The associations and correlations of parameters, and the difference in groups of severity were analyzed statistically with Statistical Package for Social Sciences (SPSS), using nonparametric measures.

Results

The spirometric parameters showed significant correlation with increasing New York Heart Association (NYHA) functional class (FC): forced vital capacity (FVC, r = −0.4*, p = 0.04), forced expiratory volume in one second (FEV1, r = −0.5*, p = 0.01), FEV1/FVC (r = −0.44*, p = 0.02), and with pulmonary venous congestion (PVC): FVC (r = −0.41*, p = 0.04) and FEV1 (r = −0.41*, p = 0.04). Cardiothoracic ratio (CTR) correlated only with FEV1 (r = −0.461*, p = 0.02) and peripheral saturation of oxygen (SPO2, r = −0.401*, p = 0.04). There was no linear correlation to duration of symptoms, mitral valve orifice area, or pulmonary hypertension, except for MV gradient with PCO2 (r = 0.594**, p = 0.002). The decreased oxygenation status correlated significantly with FC, CTR, PVC, and with deranged spirometry (r = 0.495*, p = 0.02).

Conclusions

PFT derangements are seen in all grades of severity of MS and correlate well with the functional class, though no significant linear correlation with grades of severity of stenosis or pulmonary hypertension. Even the early or mild derangements in pulmonary function such as small airway obstruction in the less severe cases of normal or mild PH can be detected by simple and inexpensive methods when the conventional parameters are normal. The supplementary data from baseline arterial blood gas analysis is informative and relevant. This reclassified pulmonary function status might be prognostically predictive.

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ageing that increase the risk and severity of SARS-CoV-2–induced pneumonia. Since the risk of developing a lower airways infection is increased by the impaired clearance of inhaled pollutants or infectious agents from the small airways [ 2 ], data on

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respiratory disease . Rev. Port. Pneumol. 20 ( 1 ), 36 – 41 ( 2014 ) 2. Baraldo , Turato G , Saetta M : Pathophysiology of the small airways in chronic

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Obstruktív tüdőbetegségek súlyosbodása SARS-CoV-2-fertőzés hatására a marosvásárhelyi Pulmonológiai Klinika beteganyagában

Exacerbation of obstructive pulmonary diseases by SARS-CoV-2 infection in patients treated in the Pulmonology Clinic of Târgu Mures

Orvosi Hetilap
Authors:
Mioara Szathmáry
,
Elena-Cristina Gîrbovan
,
Hédi-Katalin Sárközi
,
Zsuzsanna Gáll
,
Mara Andreea Vultur
,
Alexandra Floriana Nemeș
,
Edith Simona Ianoși
, and
Gabriela Jimborean

pulmonary disease: From pathophysiology to therapy. Mini-review. Physiology Int. 2022; 109: 9–19. 14 Leung JM, Yang CX, Tam A, et al. ACE-2 expression in the small

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European Journal of Microbiology and Immunology
Authors:
Katja Fischer
,
Jan-Moritz Doehn
,
Christian Herr
,
Carolin Lachner
,
Annina Heinrich
,
Olivia Kershaw
,
Meike Voss
,
Max H. Jacobson
,
Achim D. Gruber
,
Matthias Clauss
,
Martin Witzenrath
,
Robert Bals
,
Birgitt Gutbier
, and
Hortense Slevogt

Introduction Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis associated with chronic inflammation of the small airways and in the lung parenchyma, as well as obstruction of the small airways

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Physiology International
Authors:
Monika Fekete
,
Zsofia Szarvas
,
Vince Fazekas-Pongor
,
Agnes Feher
,
Norbert Dosa
,
Andrea Lehoczki
,
Stefano Tarantini
, and
Janos Tamas Varga

T-L , Singhera GK , et al. ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID

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Interventional Medicine and Applied Science
Authors:
Seyed Alireza Mahdaviani
,
Sepideh Darougar
,
Davood Mansouri
,
Sabereh Tashayoie-Nejad
,
Mahshid Movahedi
,
Karim Rahimi Aghdam
,
Hosseinali Ghaffaripour
,
Nooshin Baghaie
,
Maryam Hassanzad
,
Alireza Eslaminejad
,
Atefeh Fakharian
,
Guitti Pourdowlat
,
Jalal Heshmatnia
,
Mehrdad Bakhshayeshkaram
,
Mohammadreza Boloursaz
,
Payam Tabarsi
,
Seyed Karen Hashemitari
, and
Ali Akbar Velayati

group and was predominantly the result of repeated and prolonged infections. Small airway involvement is relatively common in CVID that leads to ventilation abnormalities and even chronic obstructive disease, which appears at CT imaging as areas

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to human surfactant proteins A and D, fibronectin, and small airway epithelial cells under shear conditions Infect Immun 74 3587 – 3596 . 110

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