Authors:N. Manin, A. Fini, A. Manin, and G. Perlovich
Enthalpies of solution and dilution of aqueous solutions of sodium diclofenac salt were measured by isoperibolic calorimeter
at 293.15, 298.15, 303.15, 308.15 and 318.15 K. The concentration of the electrolyte was restricted to solubility salt at
various temperatures and did not exceed 0.035–0.057 mol kg−1 values depending on the studied temperature. The virial coefficients were derived from Pitzer’s model and the excess thermodynamic
functions of both the solution and the components of the solution were calculated. The analysis of thermodynamic characteristics
of the solution from concentration and temperatures was carried out and discussed.
Authors:Y. A. Ribeiro, J. D. S. de Oliveira, M. I. G. Leles, S. A. Juiz, and M. Ionashiro
Thermogravimetry, derivative thermogravimetry (TG, DTG) and differential scanning calorimetry (DSC), were used to study the thermal behaviour of mefenamic acid, ibuprofen, acetaminophen, sodium diclofenac, phenylbutazone, dipyrone and salicylamide. The results led to thermal stability data and also to the interpretation concerning the thermal decomposition.
Authors:B. Pose-Vilarnovo, C. Rodríguez-Tenreiro Sánchez, N. Diéguez Moure, J. Vila-Jato, and J. Torres-Labandeira
The effect of a hydrophilic polymer, hydroxypropylmethyl cellulose K4M, on the complexation of diclofenac sodium with b- and
hydroxypropyl-b-cyclodextrins has been studied. Multicomponent systems were prepared with the drug, both cyclodextrin and
the polymer. Phase solubility diagrams revealed the positive effect of the polymer on the complexation of the drug but this
effect was found after autoclaving the solutions. Solid inclusion complexes were prepared by freeze-drying and characterized
by thermal analysis (DSC) and X-ray diffractometry. In solid state, binary inclusion complexes enhance the dissolution behaviour
of diclofenac but, from the b-cyclodextrin multicomponent complex, the polymer controls the release of the drug. In the case
of hydroxy- propyl-b-cyclodextrin multicomponent system, the solubility of the drugs increases significantly compared with
the binary complex.
Authors:Irene Pasquali, R. Bettini, and F. Giordano
This work aims to investigate the thermal behaviour of diclofenac, diclofenac sodium, and NaHCO3 both as single components and binary mixtures. In particular, the melting point and latent heat of fusion binary diagrams
of the diclofenac sodium/diclofenac mixtures at different mole fraction compositions were investigated in order to gain information
about the thermal behaviour of their solid mixtures. A good agreement between liquidus curves, calculated by the Schroeder-Van
Laar equation from fusion enthalpies and temperatures, and the experimental results was found. For all binary compositions,
an endothermic effect at 153�C, probably due to the eutectic fusion, is present.
Authors:Thiago O. Carvalho, Ana E. B. Matias, Lilian R. Braga, Sheila M. Evangelista, and Alexandre G. S. Prado
obtained from Genix Pharmaceutical Industry (Brazil) and sodiumdiclofenac and sodium dipyrone were obtained from Aldrich. The reagents as acetic acid, sodium hydroxide, and glutaraldehyde were obtained from Vetec.
diclofenac–paracetamol molecular interaction in aqueous binary solutions by the solution calorimetric method. Whereas Alves et al. [ 11 ] used a heat conduction microcalorimeter to measure the enthalpies of dissolution of sodiumdiclofenac and paracetamol in
Authors:M. Rizk, S. Toubar, E. Ramzy, and Marwa Helmy
, 332 – 334 . 31. Navas , N. ; Ureña , R. ; Capitan-Vallvey , L. F. Determination of celecoxib, rofecoxib, sodiumdiclofenac and niflumic acid in human serum samples by HPLC with DAD detection . Chromatographia . 2008 , 67 , 55 – 61 . https