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Abstract  

Enthalpies of solution and dilution of aqueous solutions of sodium diclofenac salt were measured by isoperibolic calorimeter at 293.15, 298.15, 303.15, 308.15 and 318.15 K. The concentration of the electrolyte was restricted to solubility salt at various temperatures and did not exceed 0.035–0.057 mol kg−1 values depending on the studied temperature. The virial coefficients were derived from Pitzer’s model and the excess thermodynamic functions of both the solution and the components of the solution were calculated. The analysis of thermodynamic characteristics of the solution from concentration and temperatures was carried out and discussed.

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Journal of Thermal Analysis and Calorimetry
Authors: Y. A. Ribeiro, J. D. S. de Oliveira, M. I. G. Leles, S. A. Juiz, and M. Ionashiro

Thermogravimetry, derivative thermogravimetry (TG, DTG) and differential scanning calorimetry (DSC), were used to study the thermal behaviour of mefenamic acid, ibuprofen, acetaminophen, sodium diclofenac, phenylbutazone, dipyrone and salicylamide. The results led to thermal stability data and also to the interpretation concerning the thermal decomposition.

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Journal of Thermal Analysis and Calorimetry
Authors: B. Pose-Vilarnovo, C. Rodríguez-Tenreiro Sánchez, N. Diéguez Moure, J. Vila-Jato, and J. Torres-Labandeira

Abstract  

The effect of a hydrophilic polymer, hydroxypropylmethyl cellulose K4M, on the complexation of diclofenac sodium with b- and hydroxypropyl-b-cyclodextrins has been studied. Multicomponent systems were prepared with the drug, both cyclodextrin and the polymer. Phase solubility diagrams revealed the positive effect of the polymer on the complexation of the drug but this effect was found after autoclaving the solutions. Solid inclusion complexes were prepared by freeze-drying and characterized by thermal analysis (DSC) and X-ray diffractometry. In solid state, binary inclusion complexes enhance the dissolution behaviour of diclofenac but, from the b-cyclodextrin multicomponent complex, the polymer controls the release of the drug. In the case of hydroxy- propyl-b-cyclodextrin multicomponent system, the solubility of the drugs increases significantly compared with the binary complex.

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Abstract  

This work aims to investigate the thermal behaviour of diclofenac, diclofenac sodium, and NaHCO3 both as single components and binary mixtures. In particular, the melting point and latent heat of fusion binary diagrams of the diclofenac sodium/diclofenac mixtures at different mole fraction compositions were investigated in order to gain information about the thermal behaviour of their solid mixtures. A good agreement between liquidus curves, calculated by the Schroeder-Van Laar equation from fusion enthalpies and temperatures, and the experimental results was found. For all binary compositions, an endothermic effect at 153�C, probably due to the eutectic fusion, is present.

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obtained from Genix Pharmaceutical Industry (Brazil) and sodium diclofenac and sodium dipyrone were obtained from Aldrich. The reagents as acetic acid, sodium hydroxide, and glutaraldehyde were obtained from Vetec. Preparation of

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.: Clinical study of the therapeutic efficacy and tolerance of nimesulide in comparison with a sodium diclofenac in the treatment of acute superficial thrombophlebitis. Minerva Cardioangiol., 1992

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diclofenac–paracetamol molecular interaction in aqueous binary solutions by the solution calorimetric method. Whereas Alves et al. [ 11 ] used a heat conduction microcalorimeter to measure the enthalpies of dissolution of sodium diclofenac and paracetamol in

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Thermal stability of ketoprofen—active substance and tablets

Part 1. Kinetic study of the active substance under non-isothermal conditions

Journal of Thermal Analysis and Calorimetry
Authors: Dumitru Tiţa, Adriana Fuliaş, and Bogdan Tiţa

sodium diclofenac . Rev Chim (Bucureşti) 60 : 524 – 528 . 29. Fuliaş , A , Tiţa , B , Bandur , G , Tiţa , D 2009 Thermal decomposition of some benzodiazepines under non

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Journal of Thermal Analysis and Calorimetry
Authors: Bogdan Tiţa, Adriana Fuliaş, Zoltan Szabadai, Gerlinde Rusu, Geza Bandur, and Dumitru Tiţa

sodium diclofenac . Rev Chim (Bucureşti) 60 : 524 – 528 . 15. Fuliaş , A , Tiţa , B , Bandur , G , Tiţa , D 2009 Thermal decomposition of some benzodiazepines under non

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, 332 – 334 . 31. Navas , N. ; Ureña , R. ; Capitan-Vallvey , L. F. Determination of celecoxib, rofecoxib, sodium diclofenac and niflumic acid in human serum samples by HPLC with DAD detection . Chromatographia . 2008 , 67 , 55 – 61 . https

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