The STEP NC system that replaces the ISO 6983 standard has been under development more than 10 years. However, just a few control developers find alternatives in the new standard that includes several completed modules. The paper shows in which role the industrial companies could use a new generation NC standard. The paper concludes the parameters that support the setting up of a mathematical model for a place-centered application with the help of case studies. The expected powerful opportunities of the application of a new generation NC standard are described with the help of case studies.
Within industrial thermal analysis applications there is an increasing requirement for more rigorous standardisation to ensure
that the data obtained can be reproduced within any other laboratory, using the same procedures. Fundamental to all Quality
Accreditation programmes is the need to generate ‘equivalent data’. The paper highlights TA applications where this is not
achieved despite the use of standard calibration procedures, where true calibration is difficult to establish due to hardware/software
design limitations or the absence of proven and traceable reference materials. Lack of standardisation can have important
commercial or legal consequences for both instrument manufacturer and end-user.
Whereas standardization has conventionally been believed to be an obstacle to innovation, there are growing public policies and academic literature that perceive standardization as an ‘enabler or catalyst’ for
The present state of the certification of the reference materials for thermal analysis is considered. Six sets of reference materials for temperature calibration, resulting from the research work of the ICTA Standardization Committee, are discussed.
Previous study showed that the standardised 50% aqueous-methanol extract of Eurycoma longifolia (TAF-273) affected phase 1 aminopyrine metabolism especially in adult male and female rat hepatocytes. The present study evaluated the molecular mechanism of TAF-273 on phase 1 aminopyrine metabolism in adult male and female rat hepatocytes by using ten cellular stimulants/inhibitors. The study suggested that the effect of TAF-273 on hepatic phase 1 aminopyrine metabolism in adult male rats was probably mediated through the inhibition of tyrosine kinases and through the activation of G-protein, protein kinase G, protein kinase A in the cAMP pathway, calmodulin and protein kinase C. On the contrary, the extract affected adult female rat hepatocytes, only through the activation of G-protein, protein kinase G, protein kinase A in the cAMP pathway and protein kinase C. The effect of TAF-273 on aminopyrine metabolism in the presence of trifluoperazine, phorbol myristate acetate and genistein also exhibited significant difference (P<0.05) between male and female rats. The rate of aminopyrine metabolism was higher in male rats than in female rats and the effect of TAF-273 on aminopyrine metabolism at the molecular level was different in male and female rats on the activation of calmodulin, protein kinase C and tyrosine kinases.
Modern DSC instruments generally give very reproducible results that are ideal for quality assurance work. However, various
corrections are needed before quantitative data are obtained. Since the corrections differ from one type of instrument to
another, it is important to ensure that they are all properly carried out. Without these corrections, it is fruitless to compare
data from different sources. The types of problem, and their solutions, are discussed.