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,056 participants in 14 randomised trials of statins. Lancet, 2005, 366 , 1267–1278. Kearney P. M. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90

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Thermal and kinetic study of statins

Simvastatin and lovastatin

Journal of Thermal Analysis and Calorimetry
Authors: M. Souza, Marta Conceição, M. Silva, L. Soledade, and A. Souza

Abstract  

Statins are a group of lipoproteins that are used in medicine to treat the high cholesterol level. The effectiveness of statins in reducing the cholesterol level is significant and in long time scale the reduction of the cholesterol level helps to avoid the incidence of degenerative diseases. Simvastatin and lovastatin are belonging to the ‘statins’ family, one of the pharmacologic groups used in the control of dislipidemy. The objective of this work is the thermal stability and kinetic study of the active forms of simvastatin and lovastatin. Thermal data indicated that lovastatin and simvastatin are stable up to 190 and 170°C in air and up to 205 and 203°C in nitrogen, respectively. For melting temperatures DSC curves showed good correlation with the literature data. Comparing the activation energies of the statins at heating rate of 10°C min–1, lovastatin is more stable than simvastatin under the applied experimental conditions.

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Introduction Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. It is a new class of drug more prescribed for the treatment of hypercholesterolemia in patients with cardiovascular disease and those at high risk of

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Orvosi Hetilap
Authors: Veronika Sági, László Herszényi, Zsolt Tulassay, and Beáta Gasztonyi

.: Beyond aspirin – cancer prevention with statins, metformin and bisphosphonates. Nat. Rev. Clin. Oncol., 2013, 10 (11), 625–642. Clendening, J. W., Pandyra, A., Boutros, P. C., et al.: Dysregulation of the

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Orvosi Hetilap
Authors: Mariann Harangi, Noémi Zsíros, Lilla Juhász, and György Paragh

Cholesterol Treatment Trialists’ (CTT) Collaborators, Mihaylova, B., Emberson, J., Blackwell, L., et al.: The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27

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dyslipidaemia guidelines? Arch. Med. Sci., 2012, 8 (4), 608–613. 5 Kiss, Z., Nagy, L., Reiber, I., et al.: Resistence with statin therapy in Hungary. Arch

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statins: Focus on clinical pharmacokinetics and drug interactions. American Heart Association, Circulation 109 , III-50–III-57, DOI: 10.1161/01.CIR.0000131519.15067.1f Corsini A

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Harper, C. R., Jacobson, T. A.: The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis. Curr. Opin. Lipidol., 2007, 18 , 401

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References [1]. C. R. Harper T. A. Jacobson 2007 The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis Curr. Opin. Lipidol. 18 401 – 408 . [2]. J.M. McKenney M. H. Davidson T. A. Jacobson 2006

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significant lipid modification to CHD prevention are the central to the pathogenesis of atherosclerosis. One of the main drugs prescribed to the treatment of hypercholesterolaemia are statins [ 1 ]. This is because statins drugs tend to enhance the stability

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