Authors:M. Souza, Marta Conceição, M. Silva, L. Soledade, and A. Souza
Statins are a group of lipoproteins that
are used in medicine to treat the high cholesterol level. The effectiveness
of statins in reducing the cholesterol level is significant and in long time
scale the reduction of the cholesterol level helps to avoid the incidence
of degenerative diseases. Simvastatin and lovastatin are belonging to the
‘statins’ family, one of the pharmacologic groups used in the
control of dislipidemy. The objective of this work is the thermal stability
and kinetic study of the active forms of simvastatin and lovastatin.
Thermal data indicated that lovastatin and simvastatin are stable up
to 190 and 170°C in air and up to 205 and 203°C in nitrogen, respectively.
For melting temperatures DSC curves showed good correlation with the literature
data. Comparing the activation energies of the statins at heating rate of
10°C min–1, lovastatin is more stable
than simvastatin under the applied experimental conditions.
Authors:H. Belmir, A. Abourriche, A. Bennamara, T. Saffaj, and Bouchaib Ihssane
Introduction Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. It is a new class of drug more prescribed for the treatment of hypercholesterolemia in patients with cardiovascular disease and those at high risk of
Authors:Veronika Sági, László Herszényi, Zsolt Tulassay, and Beáta Gasztonyi
.: Beyond aspirin – cancer prevention with statins, metformin and bisphosphonates. Nat. Rev. Clin. Oncol., 2013, 10 (11), 625–642.
Clendening, J. W., Pandyra, A., Boutros, P. C., et al.: Dysregulation of the
Authors:Mariann Harangi, Noémi Zsíros, Lilla Juhász, and György Paragh
Cholesterol Treatment Trialists’ (CTT) Collaborators, Mihaylova, B., Emberson, J., Blackwell, L., et al.: The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27
. C. R. Harper T. A. Jacobson 2007 The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis Curr. Opin. Lipidol. 18 401 – 408 .
. J.M. McKenney M. H. Davidson T. A. Jacobson 2006
Authors:Wael Alshitari, Fatimah Al-Shehri, Deia Abd El-Hady, and Hassan M. Albishri
significant lipid modification to CHD prevention are the central to the pathogenesis of atherosclerosis. One of the main drugs prescribed to the treatment of hypercholesterolaemia are statins [ 1 ]. This is because statins drugs tend to enhance the stability