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were developed for their determinations in the pharmaceutical tablets form or biological matrixes [ 5 , 6 ]. There is a huge tendency towards greening analytical approaches owing to its friendly impact towards the environment, which is a great of
available in 50 mg, 100 mg, and 200 mg strengths tablets. The recommended starting dose is 100 mg, but based on individual efficacy and tolerability, the dose can be increased to 200 mg. Maximum daily dose is 200 mg/day. It has the molecular formula C 23 H
Abstract
This study demonstrates the thermalanalysis applications in compatibility and stability studies of the propranolol binary mixture sand tablets A and B. The propranolol binary mixtures were prepared in the laboratory and compared to the fully formulated tablets using the thermogravimetric (TG) and calorimetric(DSC) methods. DSC of binary mixtures showed similar phase transition to propranolol drug. The tablets phase transition decreased and there was no detectable significant interaction in propranolol–lactose mixture and tablets. The DSC-photovisual test revealed an interaction similar to the Maillard reaction. The TG isothermal study showed a difference in the profile between the drug and tablets due excipients quality and problems in manufacture process. The kinetic parameters indicated a lower stability for the tablets than propranolol drug. The thermal techniques thermally differentiated the propranolol preparations demonstrating the importance in the design development of pharmaceuticals solid-dosage form.
Summary
A new, simple, accurate, and precise high-performance thin-layer chromatographic (HPTLC) method has been established for simultaneous analysis of eprosartan and hydrochlorothiazide in tablet formulations. Standard and sample solutions of eprosartan and hydrochlorothiazide were applied to precoated silica gel G 60 F254 HPTLC plates and the plates were developed with benzene-methanol-formic acid 7:3:0.1 (υ/υ) as mobile phase. Detection and evaluation of chromatograms was performed densitometrically at 272 nm. The retention factors of eprosartan and hydrochlorothiazide were 0.76 and 0.57, respectively. The linear range was 4.8–43.2 μg per spot for eprosartan and 0.15–1.35 μg per spot for hydrochlorothiazide; the correlation coefficients, r, were 0.998 and 0.999, respectively. The method was validated and successfully used for analysis of the drugs in tablets.
A simple and selective liquid chromatographic method was developed for the simultaneous determination of tenofovir disoproxil fumarate (TEN) and emtricitabine (EMT) in combined tablets. The method is based on separation of TEN and EMT on a Zorbax SB-C8 column, 5 μm, 4.6 × 250 mm, with a mobile phase consisting of 50 mM disodium hydrogen phosphate-acetonitrile (50:50, v/v). The mobile phase contains 0.1% triethylamine (TEA) and was adjusted to pH 6.0. Quantification of the analytes is achieved with diode array — ultraviolet detector (DAD-UV) at 260 and 280 nm for TEN and EMT, respectively, based on peak area. Different variables affecting the method were carefully investigated and optimized. Reliability and analytical performance of the proposed method, including linearity, range, precision, accuracy, and detection and quantitation limits, were statistically validated. The high-performance liquid chromatography (HPLC) method was successfully applied for determination of each drug in their binary tablets.
Bowman who kindly answered me and informed me that they are working on deciphering the new tablets (“about a dozen or so tablets with substantial text, mainly letters”) and preparing an edition and a previous presentation to appear in the journal
expectations associated with perceptual characteristics: ethnic factors Percept. Mot. Skills 55 915 – 918 . [15]. F. Köteles Gy. Bárdos 2007 Expectations of drug effects based on colours and sizes of tablets Mentálhig. Pszichoszom. 8
1 INTRODUCTION For more than one hundred years, curse tablets have been representing one of the main direct sources of Vulgar Latin. Besides being essential for scholars in field of ancient magic and religion, these small sheets of metal usually
Introduction and background A recent article by Qureshi [ 1 ] goes directly to the problem in the development and validation of drug dissolution (disintegration of oral solid dose tablets and capsules): dissolution tests used
effects based on colour and size of tablets Mentálhigiéné és Pszichoszomatika 8 277 – 290 . [6]. L. W. Buckalew K. E. Coffield 1982 An investigation of drug expectancy as a function of capsule colour, size, and preparation form J. Clin