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Acta Microbiologica et Immunologica Hungarica
Authors: Marzieh Aligholi, Mohammad Emaneini, Morovat Taherikalani, Shadi Shahsavan, Fereshteh Jabalameli, Parisa Asadollahi, Babak Khoramian, and Mohammad Eslampour

. R., Appelbaum, P. C.: Activities and time-kill studies of selected penicillins, beta-lactamase inhibitor combinations, and glycopeptides against Enterococcus faecalis . Antimicrob. Agents Chemother. 42 , 857–861 (1998

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., Pfaller, M. A.: Influence of test conditions on antifungal time-kill curve results: proposed for standardized methods. Antimicrob Agents Chemother 42 , 1207 (1998). Pfaller M. A

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vancomycin, respectively. Time-kill studies and growth arrest conditions Time-kill assays were performed by methods based on the CLSI standard [ 10 ]. Mueller–Hinton broth was used in 10 ml final volumes. Antibiotics were

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Acta Microbiologica et Immunologica Hungarica
Authors: Máté Szász, Mária Hajdú, Natasa Pesti, Mónika Domahidy, Katalin Kristóf, ákos Zahár, Károly Nagy, and Dóra Szabó

Biofilm-forming Staphylococcus epidermidis strains are common cause of the periprosthetic infection. The treatment of the periprosthetic infection is very problematic, so the prevention of these infections by an antibiotic containing prothesis could be an option for prevention.The purpose of the present study was to examine the in vitro effects of drug delivery systems (DDSs), namely Wax 1 and Wax 2 with different vancomycin content: 0.5, 1, 2 and 4 mg. In order to control the antibacterial activity of DDSs killing curve study was performed and in order to determine the antibiotic release and the antibiotic peak concentration from the DDSs biological assay was carried out.The time kill curve studies showed, that both DDSs with all vancomycin concentration decreased significantly the bacterial counts, however, Wax 2 with 4 mg vancomycin significantly decreased the bacterial count than all the other groups.The vancomycin release was the best with the highest peak concentration from DDSs with 4 mg vancomycin contain; it was significantly better than in the other groups, however, no significant difference was observed between Wax 1 and Wax 2 in this respect.These findings suggest that Wax 2 with 4 mg vancomycin content could be a potential agent for clinical use.

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Susceptibility Tests for Bacteria that Grow Aerobically, 4th edition. Approved Standard-M7-A4 (1997). Spangler, S. K., Jacobs, M. R., Appelbaum, P. C.: Time-kill studies on susceptibility of nine penicillin susceptible and

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Acta Microbiologica et Immunologica Hungarica
Authors: Béla Kádár, Béla Kocsis, Ákos Tóth, Ivelina Damjanova, Máté Szász, Katalin Kristóf, Károly Nagy, and Dóra Szabó

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay. Int J Antimicrob Agents 37 , 244–247 (2011). Tsakris A. Activity of tigecycline alone

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over 24 h intervals, placed on PCA (Plate Count Agar) plate in triplicate and incubated at 37 °C for 24 h. Time-kill curves were realised by plotting log 10 CFU ml –1 against time (h). 1.6 Bacteriolysis and nucleic leakage To study the integrity of

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Bonapace, C.R., White, R.L., Friedrich, L.V., Bosso, J.A.: Evaluation of antibiotic synergy against Acinetobacter baumannii : a comparison with Etest, time-kill, and checkerboard methods. Diagn Micr Inf Dis 38 , 43–50 (2000

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within 24 hours of co-incubation. The authors measured an MIC of capsaicin against P. gingivalis of 16 mg/L and an MBC of 64 mg/L. Kinetic time-kill studies revealed that P. gingivalis growth was inhibited in a capsaicin concentration- and time

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