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considerations. J Trauma 2006; 60(6 Suppl): S3–S11. 2 Chang R, Cardenas JC, Wade CE, et al. Advances in the understanding of trauma-induced coagulopathy. Blood 2016; 128: 1043

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individualized goal-directed therapy for trauma-induced coagulopathy. Scand J Trauma Resusc Emerg Med. 2012; 20: 15. 53 Kozek-Langenecker S. Management of massive operative blood loss

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trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. Lancet Haematol. 2017; 4: e258–e271

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; 389: 2105–2116. [Correction: Lancet 2017; 389: 2104.] 48 Innerhofer P, Fries D, Mittermayr M, et al. Reversal of trauma-induced coagulopathy using first

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