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This study was designed to establish serum cardiac troponin I (cTnI) concentrations in healthy newborn goat kids and in those with cardiac nutritional muscular dystrophy (NMD). Thirty-five single full-term newborn goat kids (20 males and 15 females; age: 6.1 ± 3.5 h; weight 3.4 ± 0.68 kg), together with their respective mothers (Group 1; G1) were enrolled consecutively. Thirty-one goat kids (age: 9.5 ± 4.3 days) with NMD, together with 20 control goat kids (age: 7.8 ± 4.3 days) were also included in this study (Group 2; G2). Blood samples were collected from G1 within 12 h of birth and from G2 on admission. Serum samples were collected and analysed for cTnI. In G1, the mean serum concentration of cTnI in goat kids was 0.290 ± 0.37 ng/mL, with no statistically significant difference between male and female kids (P = 0.61). The mean cTnI concentration in the does was 0.017 ± 0.04, ng/mL. Serum values of cTnI in the goat kids and in their respective mothers differed significantly (P = 0.0001). In G2, the mean cTnI concentration was 0.02 ± 0.05 ng/mL in the control and 11.18 ± 20.07 ng/mL in the diseased goat kids, with a statistically significant difference between diseased and control goat kids (P = 0.017). Serum concentrations of cTnI are higher in goat kids than in their respective mothers. In conclusion, the cTnI assay appears to be a sensitive and specific marker for myocardial injury in goat kids.

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Orvosi Hetilap
Authors:
Eszter Szánthó
,
Zoltán Szabó
,
József Varga
,
György Paragh
, and
Anna V. Oláh

. 2009 361 858 867 Keller, T., Zeller, T., Peetz, D. és mtsai: Sensitive troponin I assay in early diagnosis

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The main target of this study was to measure the influence of sumac juice drink on muscle indices and pain during an acute, intense exercise for 30 days. Forty healthy volunteers (15–25 years) were involved in aerobic exercise program for 4 weeks. Participants ingested sumac juice or placebo drink twice daily for 30 days. All participants were subjected for the evaluation of pain and estimation of serum: creatine kinase (CK), lactic acid dehydrogenase (LDH), troponin I, hydroxyproline (hyp), total antioxidant capacity (TAC), and in vitro antioxidant activity of sumac juice using pre-validated visual analog scale, colorimetric and immunoassays. The participants of both groups, placebo and sumac, showed an increment in pain scores both during exercise and post-exercise intervals. However, the sumac juice group showed a significant smaller increase in the pain scores compared to the placebo group. Participants in the sumac juice group were more willing to use the drink in the future. They achieved a higher satisfaction of sumac juice in ameliorating and the reduction of pain. Also, the sumac group showed a significant enhancement in the level of CK, LDH, troponin I, hyp, along with significant increase in serum (TAC) compared to the placebo group. The protective activity of muscle may relate to the antioxidant activity of phenolic component(s) in sumac juice as measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging (87.9%) and β-carotene–linoleic acid (68.7%) assays. These data suggest that oral administration of sumac juice may have a beneficial effect on muscle performance among athletes.

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Orvosi Hetilap
Authors:
Ferenc Kovács
,
Ibolya Kocsis
,
Marina Varga
,
Enikő Sárváry
, and
György Bicsák

Babić, Z., Bogdanović, Z., Dorosulić, Z., et al.: Quantitative analysis of troponin I serum values in patients with acute cholecystitis. Coll. Antropol., 2012, 36 (1), 145–150. 10

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. 2005 258 391 393 Moammar, M. Q., Ali, M. I., Mahmood, N. A., et al.: Cardiac troponin I levels and

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Acta Veterinaria Hungarica
Authors:
Hayoon Lee
,
Dohee Lee
,
Jooyoung Park
,
Taesik Yun
,
Yoonhoi Koo
,
Yeon Chae
,
Byeong-Teck Kang
,
Mhan-Pyo Yang
, and
Hakhyun Kim

presents the occurrence of myocardial damage due to excessive thyroid hormone levels, which may have caused heart failure based on the observed high cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) values, as well as on

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Serum creatine phosphokinase (CK-MB) activity and troponin I (cTnI) level were measured as markers for cardiac muscle damage. CK-MB activity was determined spectrophotometrically at 340 nm using commercially available kits (Stanbio Laboratory, Inc., TX

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Physiology International
Authors:
Tanja Sobot
,
Zorislava Bajic
,
Ranko Skrbic
,
Snezana Uletilovic
,
Nebojsa Mandic-Kovacevic
,
Tanja Cvjetkovic
,
Ugljesa Malicevic
,
Djordje Djukanovic
,
Milica Gajic Bojic
,
Sanja Jovicic
,
Maja Barudzija
,
Milos P. Stojiljkovic
, and
Dragan M. Djuric

concentration of high-sensitivity troponin I (hsTnI) and homocysteine (Hcy) were measured on Abbot Alinity ci-series by chemiluminescent microparticle immunoassay (CMIA) [ 16 ]. Oxidative stress markers Prooxidant markers, such as superoxide anion radical (O 2

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Acta Veterinaria Hungarica
Authors:
Ugur Aydogdu
,
Ramazan Yildiz
,
Hasan Guzelbektes
,
Alparslan Coskun
, and
Ismail Sen

The aim of this study was to determine the clinical relevance of cardiac biomarkers [troponin I and T, creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH)] in premature calves with respiratory distress syndrome. Seventy premature calves were admitted to the clinic within 24 h after birth. Respiratory distress syndrome was diagnosed in premature calves by clinical examination and venous blood gas analysis. Ten healthy calves, aged 5 days, were used as control. Cardiac troponin I and T were analysed using ELISA and ELFA, respectively. Serum CK-MB and LDH were also analysed in an automatic analyser. The calves had low venous pH, pO2, O2 saturation and high pCO2 values consistent with dyspnoea, hypoxaemia, and inadequate oxygen delivery. Mean serum troponin I, troponin T, CK-MB and LDH levels were increased in the premature calves compared to the control group. In conclusion, the results in this study demonstrated that serum CK-MB, troponin I and troponin T concentrations could be used for evaluating myocardial injury in premature calves with respiratory distress syndrome.

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Acta Veterinaria Hungarica
Authors:
Ayse Er
,
Feray Altan
,
Gul Cetin
,
Burak Dik
,
Muammer Elmas
, and
Enver Yazar

The aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, β-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.

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