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6102 6108 Travis, S. P. L., Stange, E. F., Lémann, M. és mtsai: European evidence-based consensus on the management of ulcerative colitis, current management. J
11 7525 7530 Jantchou, P., Monnet, E., Carbonnel, F.: Environmental risk factors in Crohn’s disease and ulcerative colitis (excluding
., Papadakis, K. A.: Visilizumab induces apoptosis of mucosal T-lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways. Clin. Immunol., 2008, 127 , 322–329. Papadakis K. A
Barreiro, P., Pinto Marques, P., Couto, G., et al.: Autoimmune pancreatitis and ulcerative colitis: A clinical challenge of a true association. GE J. Port. Gastrenterol., 2013, 20, 36
European Federation of Crohn’s and Ulcerative Colitis Associations: Results from the EFCCA Pan-European survey of Crohn’s disease and ulcerative colitis patients. Available at http://www.efcca.org/final_pan_eu_survey_fact_sheet.pdf , 2005
Kornbluth, A., Sachar, D. B.: Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee. Am. J. Gastroenterol., 2004, 99
Introduction Inflammatory bowel disease (IBD), is a chronic and relapsing non-specific inflammatory intestinal disease including ulcerative colitis (UC) and Crohn's disease (CD), which is hallmarked by a disturbance in
Sood, A., Midha, V., Sood, N. et al.: Incidence and prevalence of ulcerative colitis in Punjab, North India. Gut, 2003, 52 , 1587–1590. Sood N. Incidence and prevalence of
Abstract
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) in which there is recurrent inflammation of the mucous membranes of the colon. Inflammation is accompanied by the production of reactive oxygen species (ROS) including, amongst others, hydrogen peroxide. Selenium in the form of the selenoprotein glutathione peroxidase (GSH-Px) acts as a catalyst in the reaction which reduces hydrogen peroxide to water. It may therefore beneficial to supplement the diets of patients who suffer from UC with selenium. In this preliminary study nine patients suffering from moderate UC were supplemented with selenium-
tablets (300 
g Se per tablet) twice daily. Blood samples were taken at the start of the trial and at 1, 2 and 4 week intervals. Freeze-dried serum samples were analysed for their selenium content using the technique of instrumental neutron activation analysis (INAA). Samples were also analysed by particle induced X-ray emission (PIXE) to monitor other trace elements levels. Selenium concentrations were found to increase during supplementation and iron concentrations to decrease. Stool frequency was also found to improve suggesting that ROS may be important in the pathogenesis of UC.
References 1 Solberg, I. C., Lygren, I., Jahnsen, J., et al.: Clinical course during the first 10 years of ulcerative colitis: results from a population
