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Interventional Medicine and Applied Science
Authors: Ahmet Akça, Meriban Karadoğan, Demir Kürşat Yildiz, Funda Çorapçioğlu and Yonca Anik

A 2-year-old patient with a history of non-Hodgkin’s lymphoma (NHL) was presented to our hospital with the complaint of shortness of breath and wheezing. Posteroanterior chest radiograph revealed hyperlucency and hyperexpansion of the right hemithorax. We performed computed tomography (CT) because of a suspicion of foreign body aspiration. CT revealed right main bronchus occlusion by a hypodense lesion. Bronchoscopy revealed a mass lesion in the right main bronchus which was histopathologically diagnosed as NHL. Only a few cases of endobronchial recurrence of lymphoma have been reported in the current literature, but there is no reported case in a pediatric patient.

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Orvosi Hetilap
Authors: Ferenc Harangi, Katalin Lőrinczy, Anett Lázár, Mária Örkényi, Mária Adonyi and Béla Sebők

., Russel, G., Adam, M. G. és mtsai: Prevalence of asthma and wheeze in the Highlands of Scotland. Arch. Dis. Child., 1994, 71 , 211–216. Adam M. G. Prevalence of asthma and wheeze

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Acta Microbiologica et Immunologica Hungarica
Authors: Mehrdad Mohammadi, Jila Yavarian, Vajihe Karbasizade, Sharareh Moghim, Bahram Nasr Esfahani and Nafiseh Sadat Hosseini

amplification of NP1, NS1 or/and the VP1/2 gene, or other nucleic acid-based determination methods [ 8 – 10 ]. HBoV clinical manifestations might vary in infants and toddlers and include fever, wheezing, coughing, and rhinorrhea [ 11 , 12 ]. There are four

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Acta Microbiologica et Immunologica Hungarica
Authors: Péter Pankovics, Ákos Boros, Hajnalka Szabó, Gyöngyi Székely, Kálmán Gyurkovits and Gábor Reuter

Human enterovirus 109 (EV109) is a recently identified recombinant enterovirus in family Picornaviridae from acute paediatric respiratory illness in Nicaragua. EV109 have not been reported elsewhere. Our aims were the molecular detection and genetic analysis of EV109 from acute childhood respiratory infections in Hungary. Nasopharyngeal aspirates were collected from children under age of 10 years with acute respiratory infections treated in Department of Pulmonology, Kaposi Mór Teaching Hospital, Mosdós, Hungary. Samples were taken from 15 October to 15 May in two respiratory seasons 2005/2006 and 2006/2007. Samples were tested using EV109 specific VP1 primers by RT-PCR method. One (1.1%) of the 92 nasopharyngeal aspirates was positive for EV109 collected from a 2.5-year-old child in January, 2007. The main symptoms were dropping nose, fever (38.1°C), hard cough and wheezing associated with bronchitis and pneumonia. Based upon the VP1 gene region EV109 (L87/HUN/2007, JN900470) has 93% nucleotide identity and identical recombinant pattern to the prototype EV109. This is the first detection of the novel recombinant enterovirus, EV109, in Hungary (in Europe). This study supports the possibility that EV109 is able to cause acute respiratory infections, in addition, it might be plays a part in lower respiratory disease with hospitalization in children.

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Abstract

Abstract

The human respiratory syncytial virus (hRSV) is one of the major causes of respiratory infection of infants and children worldwide. The molecular epidemiology of hRSV is unknown in Hungary.

Aims

Our aims were the molecular detection and genetic analysis of hRSV from childhood respiratory infections in Hungary.

Materials and methods

Nasopharyngeal aspirates collected from children under the age of 10 years with acute respiratory infections were provided by Pediatric Department of the Hospital for Chest Diseases in Mosdós. Samples were taken from 15 October to 15May in seasons 2005/2006 and 2006/2007. The clinical and epidemiological data were collected prospectively. The amplification of the surface fusion glycoprotein (F) and the attachment glycoprotein (G) genes of viral RNA was made by RTPCR method. PCR-products were sequenced and analyzed by phylogenetic analysis.

Results

Nasopharyngeal aspirates of 104 children were examined out of which 23 (22.1%) samples — 16 males (69.6%) and 7 females (30.4%) — (first season: 1/49, 2%; second season: 22/55, 40%) contained hRSV. The hRSV infections were taking place from December to March. The average age was 2.1 years (1 month to 8 years). The leading symptoms were dropping nose, fever, cough and wheezing. 39.1% of the hRSV infected children had underlying diseases. Based upon the F region, 22 (96%) viruses genetically belonged to the type A and 1 (4%) was classified as type B hRSV. Based upon the G region out of the 11 type A viruses 8 (72.7%) belonged to group GA5 and 3 (27.3%) to group GA2. Viral nucleotide sequence was identical in several cases.

Conclusions

To our knowledge, this is the first report on molecular detection and genetic analysis of the two types (A and B) of hRSV of children under the age of 10 with respiratory infections in Hungary. In winter and spring hRSV is an important cause of childhood respiratory infections particularly in infants, which often require hospitalization.

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and wheeze: what mediates wheezing in atopic phenotypes? Ann. Allerg. Asthma Im. , 97 , 84 – 91 . Lim , R.H. , Kobzik , L. & Dahl , M. ( 2010

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Interventional Medicine and Applied Science
Authors: Maryam Hassanzad, Seyed Alireza Nadji, Sepideh Darougar, Sabereh Tashayoie-Nejad, Mohammad Reza Boloursaz, Seyed Alireza Mahdaviani, Nooshin Baghaie, Hosseinali Ghaffaripour and Ali Akbar Velayati

hyperresponsiveness may occur in response to many common environmental triggers [ 2 , 3 ] leading to asthma exacerbations. Asthma exacerbations are acute or subacute worsening episodes of shortness of breath, coughing, wheezing, and chest tightness [ 4 ], which are

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Az emberi légúti óriássejtes vírus (hRSV) a csecsemő- és kisgyermekkori légúti fertőzések, járványok egyik leggyakoribb kórokozója világszerte. A hRSV molekuláris epidemiológiája nem ismert hazánkban, ma azonban már lehetőség van a vírus genetikai szintű kimutatására és nyomon követésére e módszerrel. Célkitűzés: A szerzők célja a hRSV molekuláris kimutatása és a vírusok genetikai elemzése volt gyermekkori légúti fertőzésekből hazánkban. Módszer: A garatmosó folyadékok a mosdósi kórházban kezelt 10 év alatti, légúti fertőzésben szenvedő gyermekektől származtak két légúti szezonból (2005/2006 és 2006/2007) október 15. és május 15. között. A klinikai és epidemiológiai adatokat prospektív módon, formanyomtatványokon gyűjtöttük. A virális RNS fúziós (F) és glikoprotein (G) génjének felsokszorozását RT-PCR módszerrel végeztük, majd a termékeket szekvenáltuk és filogenetikailag elemeztük. Eredmények: A 104 légúti mintából 23 (22,1%) – 16 fiú (69,6%) és 7 lány (30,4%) – tartalmazott hRSV-t (az első szezonban: 1/49, 2%; a második szezonban: 22/55, 40%). A hRSV-fertőzések december és március között történtek. Az átlagéletkor 2,1 év (1 hónap–8 év) volt. A vezető tünetek a következők voltak: orrfolyás, láz, köhögés és légúti nehezítettség. A hRSV-fertőzött gyermekek 39,1%-ának voltak alapbetegségei. Az F-régió alapján 22 (96%) vírusgenetikailag az A típusba tartozott, 1 (4%) a B típusba volt sorolható. A 11 A típusú vírus közül 8 (72,7%) a GA5-ös, 3 (27,3%) a GA2-es csoportba tartozik a G-régió alapján. A vírusok nukleotidsorrendje több esetben azonos volt. Következtetések: A közleményben a hRSV két típusának (A és B) – tudomásunk szerint – első hazai, közvetlen molekuláris kimutatásáról és elemzéséről számolunk be, 10 éven aluli gyermekek légúti fertőzéseiből. A hRSV a gyermekkori, elsősorban a csecsemőkori kórházi kezelést igénylő légúti fertőzések jelentős kóroki tényezője a téli-tavaszi hónapokban.

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wheezing among children of Turkish origin living in Germany. Clin. exp. Allergy , 32 , 526–531. Wahn U. Cultural adaptation is associated with atopy and wheezing among children

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pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. Jama 266 , 225–230 (1991). Golubjatnikov R. Association of Chlamydia pneumoniae (strain

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