Acta Veterinaria Hungarica
Volume/Issue:
Volume 52: Issue 3
Effect of composition and quality of diet and feeding time on the kinetics and efficacy of some anthelmintic drugs: A mini-review
Author: B. H. Ali 1
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  • 1 Department of Veterinary Medicine, King Saud University P.O. Box 10158 Buraydah, Al Gaseem Branch 81999, Saudi Arabia
Pages:
339–347
Online Publication Date:
22 Jul 2005
Publication Date:
01 Sep 2004
Article Category:
Research Article
DOI:
https://doi.org/10.1556/avet.52.2004.3.9
Keywords:
cattle; cattle; cattle; sheep; Kinetics; feed restriction; anthelmintics; feed
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This article reviews the literature dealing with the effects of composition and quality of diet and feeding time on the pharmacokinetics and efficacy of some anthelmintic drugs in ruminants. Studies have suggested that greater availability, and therefore improved anthelmintic activity, is possible through temporary feed restriction. It is also recommended that anthelmintic drugs should not be given to animals whilst they are maintained on large feed intakes, particularly of lush pasture that promotes rapid gastric transit, as this may reduce drug availability and anthelmintic efficacy. Generally, feeding animals low-quality fibrous diets reduces the passage rate of digesta and allows more time for absorption of several anthelmintic drugs and their metabolites from the gut. Some kinetic data of drugs given to animals on such diets may be slightly different, but this does not necessarily indicate alteration of the dosages of the anthelmintic drug. Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times.

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Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
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  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
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  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation		 1951
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia
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Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
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ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

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