Acta Veterinaria Hungarica
Volume/Issue:
Volume 53: Issue 3
Urinary ggt/creatinine ratio and fractional excretion of electrolytes in diarrhoeic calves
Authors: B. Ulutas 1 and M. Sahal 2
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  • 1 Department of Internal Medicine, Faculty of Veterinary Medicine, Adnan Menderes University 09016 Aydın, Turkey
  • | 2 Ankara University Ankara, Turkey
Pages:
351–359
Online Publication Date:
19 Sep 2005
Publication Date:
01 Aug 2005
Article Category:
Research Article
DOI:
https://doi.org/10.1556/avet.53.2005.3.8
Keywords:
Calves; Calves; Calves; Calves; fractional excretion; diarrhoea; fluid therapy; renal function; urinary GGT/Cr ratio
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The aim of this study was to monitor renal function in diarrhoeic calves and to determine the effectiveness of an applied fluid therapy. A total of 28 diarrhoeic (n = 18) and healthy (n = 10) Holstein-Friesian calves of different sexes, between 1 and 30 days of age, were used. Blood and urine samples were obtained from diarrhoeic calves before the treatment and then three more times at 24-h intervals during the treatment. From healthy calves, samples were taken only once. Therapy was started by the intravenous administration of 8.4% sodium bicarbonate and 0.9% sodium chloride solutions for the first 24 h, followed by the oral application of a commercial electrolyte solution (sodium chloride 3.5 g, trisodium citrate 2.9 g, potassium chloride 1.5 g and glucose anhydrous 20 g in 1 litre H2O) up to the 48th h of therapy. Before the therapy, the average levels of pH (7.10 ± 0.12), bicarbonate (HCO3-) (16.48 ± 3.80 mmol/l), base deficit (-12.65 ± 5.97 mmol/l) and fractional excretion (FE) of sodium (0.16 ± 0.11%) and potassium (15.07 ± 8.56%) were significantly lower while serum urea (17.48 ± 10.32 mmol/l) and creatinine (Cr) concentrations (169.72 ± 98.12 µmol/l), haematocrit levels (45.13 ± 13.60%) and urinary gamma glutamyl transferase (GGT)/Cr ratio (8.6 ± 4.3 × 1/103 U/µmol) were significantly higher in diarrhoeic calves than in healthy calves. Alterations in parameters indicating the presence of renal dysfunction were normalised in the diarrhoeic calves that survived (83.3%). Three calves with severe metabolic acidosis and azotaemia died at the beginning of therapy. It was concluded that the FE of Na and K (FENa, FEK) and urine GGT/Cr ratio may have an important role in assessing renal function in diarrhoeic calves and in evaluating the effectiveness of an applied fluid therapy.

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Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
Online ISSN:
1588-2705

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  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
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  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
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  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation		 1951
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia
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Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
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ISSN 0236-6290 (Print)
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