View More View Less
  • 1 University of Warmia and Mazury in Olsztyn Department of Clinical Diagnostics, Faculty of Veterinary Medicine Oczapowskiego 14 10-957 Olsztyn Poland
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The aim of the study was to evaluate the usefulness of immunomodulators in the treatment of inflammatory bowel disease (IBD) in dogs. Twenty-eight dogs diagnosed with IBD took part in the study. The animals received a food containing extruded immunomodulators: β-1,3/1,6-D-glucan, β-hydroxy-β-methyl-butyrate (HMB) and levamisole for 42 days. Whole blood samples were analysed before and after therapy assessing changes in phagocyte activity (respiratory burst activity, RBA and potential killing activity, PKA), evaluation of proliferation response of mitogen-stimulated lymphocytes and serum gamma globulin levels, lysozyme activity, ceruloplasmin levels and interleukin activity (IL-6 and IL-10). In this experiment, β-1,3/1,6-D-glucan delivered the highest level of treatment efficacy by producing the quickest therapeutic effect, lowering Canine Inflammatory Bowel Disease Activity Index (CIBDAI) values to below 3, improving histopathological parameters, decreasing IL-6 levels, increasing IL-10 concentrations, and producing remission periods longer than six months. HMB and levamisole were also effective in lowering CIBDAI scores, but the abatement of clinical symptoms was slower and less pronounced in comparison with β-1,3/1,6-D-glucan. The results indicate that β-1,3/1,6-D-glucan can be useful in the treatment of canine IBD.

  • Carey, R., Jurickova, I., Ballard, E., Bonkowski, E., Han, X., Xu, H. and Denson, L. A. (2008): Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease. Inflamm. Bowel Dis. 14, 446–457.

    Denson L. A. , 'Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease ' (2008 ) 14 Inflamm. Bowel Dis. : 446 -457.

    • Search Google Scholar
  • Chung, S. and Secombes, S. J. (1988): Analysis of events occurring within teleost macrophages during the respiratory burst. Comp. Biochem. Physiol. 89 B, 539–544.

    Secombes S. J. , 'Analysis of events occurring within teleost macrophages during the respiratory burst ' (1988 ) 89B Comp. Biochem. Physiol. : 539 -544.

    • Search Google Scholar
  • Day, M. J., Blizer, T., Mansell, J., Wilcock, B., Hall, E. J., Jergens, A., Minami, T., Willard, M. and Washabau R. (2008): Histopathological standards for the diagnosis of gastrointestinal in biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J. Comp. Path. 138(Suppl. 1), S1–S43.

    Washabau R. , 'Histopathological standards for the diagnosis of gastrointestinal in biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group ' (2008 ) 138 J. Comp. Path. : S1 -S43.

    • Search Google Scholar
  • Gasche, C., Bakos, S., Dejaco, C., Tillinger, W., Zakeri, S. and Reinisch, W. (2000): IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel. J. Clin. Immunol. 20, 362–370.

    Reinisch W. , 'IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel ' (2000 ) 20 J. Clin. Immunol. : 362 -370.

    • Search Google Scholar
  • Guarner, F. (2011): The intestinal microbiota and inflammatory bowel disease. Gastroenterol. Hepatol. 34, 147–154.

    Guarner F. , 'The intestinal microbiota and inflammatory bowel disease ' (2011 ) 34 Gastroenterol. Hepatol. : 147 -154.

    • Search Google Scholar
  • Hosokawa, T., Kusugami, K., Ina, K., Ando, T., Shinoda, M., Imada, A., Ohsuga, M., Sakai, T., Matsuura, T., Ito, K. and Kaneshiro, K. (1999): Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease. J. Gastroenterol. Hepatol. 14, 987–996.

    Kaneshiro K. , 'Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease ' (1999 ) 14 J. Gastroenterol. Hepatol. : 987 -996.

    • Search Google Scholar
  • Jergens, A. J. and Simpson, K. W. (2012): Inflammatory bowel disease in veterinary medicine. Frontiers in Bioscience E4, 1404–1419.

    Simpson K. W. , 'Inflammatory bowel disease in veterinary medicine ' (2012 ) 4 Frontiers in Bioscience : 1404 -1419.

    • Search Google Scholar
  • Jergens, A. E., Schreiner, C. A., Frank, D. E., Niyo, Y., Ahrens, F. E., Eckersall, P. D., Benson, T. J. and Evans, R. (2003): A scoring index for disease activity in canine inflammatory bowel disease. J. Vet. Intern. Med. 17, 291–297.

    Evans R. , 'A scoring index for disease activity in canine inflammatory bowel disease ' (2003 ) 17 J. Vet. Intern. Med. : 291 -297.

    • Search Google Scholar
  • Kornasio, R., Riederer, I., Butler-Browne, G., Mouly, V., Uni, Z. and Halevy, O. (2009): β-Hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways. Biochim. Biophys. Acta 1793, 755–763.

    Halevy O. , 'β-Hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways ' (2009 ) 1793 Biochim. Biophys. Acta : 755 -763.

    • Search Google Scholar
  • Mancho, C., Sainz, A., Garca-Sancho, M., Villaescusa, A., Tesouro, M. and Rodriguez-Franco, F. (2010): Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease. J. Vet. Diagn. Invest. 22, 553–558.

    Rodriguez-Franco F. , 'Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease ' (2010 ) 22 J. Vet. Diagn. Invest. : 553 -558.

    • Search Google Scholar
  • Markowitz, J., Grancher, K., Kohn, N. and Daum, F. (2002): Immunomodulatory therapy for pediatric inflammatory bowel disease: changing patterns of use, 1990–2000. Am. J. Gastroenterol. 97, 928–932.

    Daum F. , 'Immunomodulatory therapy for pediatric inflammatory bowel disease: changing patterns of use, 1990–2000 ' (2002 ) 97 Am. J. Gastroenterol. : 928 -932.

    • Search Google Scholar
  • Mitsuyama, K., Toyonaga, M. and Sata, M. (2002): Intestinal microflora as a therapeutic target in inflammatory bowel disease. J. Gastroenterol. 37(Suppl 14), 73–77.

    Sata M. , 'Intestinal microflora as a therapeutic target in inflammatory bowel disease ' (2002 ) 37 J. Gastroenterol. : 73 -77.

    • Search Google Scholar
  • Mosmann, T. (1983): Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65, 55–63.

    Mosmann T. , 'Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays ' (1983 ) 65 J. Immunol. Meth. : 55 -63.

    • Search Google Scholar
  • Nguyen Van, N., Taglinger, K., Helps, C. R., Tasker, S., Gruffydd-Jones, T. J. and Day, M. J. (2006): Measurement of cytokine mRNA expression in intestinal biopsies of cats with inflammatory enteropathy using quantitative real time RT-PCR. Vet. Immunol. Immunopathol. 113, 404–414.

    Day M. J. , 'Measurement of cytokine mRNA expression in intestinal biopsies of cats with inflammatory enteropathy using quantitative real time RT-PCR ' (2006 ) 113 Vet. Immunol. Immunopathol : 404 -414.

    • Search Google Scholar
  • Niederau, C., Backmerhoff, F., Schumacher, B. and Niederau, Ch. (1997): Inflammatory mediators and acute phase proteins in patients with Crohn’s disease and ulcerative colitis. Hepatogastroenterology 44, 90–107.

    Niederau Ch. , 'Inflammatory mediators and acute phase proteins in patients with Crohn’s disease and ulcerative colitis ' (1997 ) 44 Hepatogastroenterology : 90 -107.

    • Search Google Scholar
  • Nielsen, A. A., Nielsen, J. N., Schmedes, A., Brandslund, I. and Hey, H. (2005): Saliva interleukin-6 in patients with inflammatory bowel disease. Scand. J. Gastroenterol. 40, 1444–1448.

    Hey H. , 'Saliva interleukin-6 in patients with inflammatory bowel disease ' (2005 ) 40 Scand. J. Gastroenterol. : 1444 -1448.

    • Search Google Scholar
  • Parry, R. M., Chandau, R. C. and Shahani, R. M. (1965): A rapid and sensitive assay of muramidase. Proc. Soc. Exp. Biol. Med. 119, 384–386.

    Shahani R. M. , 'A rapid and sensitive assay of muramidase ' (1965 ) 119 Proc. Soc. Exp. Biol. Med. : 384 -386.

    • Search Google Scholar
  • Ramberg, J. E., Nelson, E. D. and Sinnott, R. A. (2010): Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr. J. 9, 1–60.

    Sinnott R. A. , 'Immunomodulatory dietary polysaccharides: a systematic review of the literature ' (2010 ) 9 Nutr. J. : 1 -60.

    • Search Google Scholar
  • Rook, G. A. W., Steele, J., Umar, J. and Dockrel, H. M. (1995): A simple method for the solubilization of reduced NBT and its use as a colorimetric assay for activation of human macrophages by gamma interferon. J. Immunol. Meth. 82, 161–167.

    Dockrel H. M. , 'A simple method for the solubilization of reduced NBT and its use as a colorimetric assay for activation of human macrophages by gamma interferon ' (1995 ) 82 J. Immunol. Meth. : 161 -167.

    • Search Google Scholar
  • Simpson, K. W. (2010): Managing chronic enteropathies in dogs. North American Veterinary Conference (NAVC), Small Animal Gastroenterology, Orlando, Florida, USA. pp. 577–580.

  • Simpson, K. W. and Jergens, A. E. (2011): Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet. Clin. North. Am. Small Anim. Pract. 41, 381–398.

    Jergens A. E. , 'Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease ' (2011 ) 41 Vet. Clin. North. Am. Small Anim. Pract. : 381 -398.

    • Search Google Scholar
  • Siwicki, A. K. and Anderson, D. P. (1993): Immunostimulation in fish: measuring the effects of stimulants by serological and immunological methods. US Fish Wildl. Service-IFI, Olsztyn 1, 17.

    Anderson D. P. , 'Immunostimulation in fish: measuring the effects of stimulants by serological and immunological methods ' (1993 ) 1 US Fish Wildl. Service-IFI, Olsztyn : 17 -.

    • Search Google Scholar
  • Siwicki, A. K. and Studnicka, M. (1986): Ceruloplasmin activity in carp (Cyprinus carpio). Isr. J. Aquacult. — Bamidgeh 38, 126–129.

    Studnicka M. , 'Ceruloplasmin activity in carp (Cyprinus carpio) ' (1986 ) 38 Isr. J. Aquacult. — Bamidgeh : 126 -129.

    • Search Google Scholar
  • Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W. and Remaut, E. (2000): Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289, 1352–1355.

    Remaut E. , 'Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 ' (2000 ) 289 Science : 1352 -1355.

    • Search Google Scholar
  • Suchodolski, J., Xenoulis, P., Paddock, C., Steiner, J. and Jergens, A. (2010): Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease. Vet. Microbiol. 142, 394–400.

    Jergens A. , 'Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease ' (2010 ) 142 Vet. Microbiol. : 394 -400.

    • Search Google Scholar
  • Volman, J. J., Ramakers, J. D. and Plat, J. (2008): Dietary modulation of immune function by β-glucans. Physiol. Behav. 94, 276–284.

    Plat J. , 'Dietary modulation of immune function by β-glucans ' (2008 ) 94 Physiol. Behav. : 276 -284.

    • Search Google Scholar
  • Washabau, R. J., Day, M. J., Willard, M. D., Hall, E. J., Jergens, A. E., Mansell, J., Minami, T. and Blizer, T. W. (2010): Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. J. Vet. Intern. Med. 24, 10–26.

    Blizer T. W. , 'Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals ' (2010 ) 24 J. Vet. Intern. Med. : 10 -26.

    • Search Google Scholar
  • Willard, M. D., Mansell, J., Fosgate, G. T., Gualtieri, M., Olivero, D., Lecoindre, P., Twedt, D. C., Collett, M. G., Day, M. J., Hall, E. J., Fergens, A. E., Simpson, J. W., Else, R. W. and Washabau, R. J. (2008): Effect of sample quality on the sensitivity of endoscopic biopsy for detecting gastric and duodenal lesions in dogs and cats. J. Vet. Intern. Med. 22, 1084–1089.

    Washabau R. J. , 'Effect of sample quality on the sensitivity of endoscopic biopsy for detecting gastric and duodenal lesions in dogs and cats ' (2008 ) 22 J. Vet. Intern. Med. : 1084 -1089.

    • Search Google Scholar

The author instruction is available in PDF.
Please, download the file from HERE.

 

MANUSCRIPT SUBMISSION

  • Impact Factor (2019): 0.991
  • Scimago Journal Rank (2019): 0.372
  • SJR Hirsch-Index (2019): 32
  • SJR Quartile Score (2019): Q2 Veterinary (miscellaneous)
  • Impact Factor (2018): 1.059
  • Scimago Journal Rank (2018): 0.517
  • SJR Hirsch-Index (2018): 30
  • SJR Quartile Score (2018): Q2 Veterinary (miscellaneous)

Language: English

Founded in 1951
Publication: One volume of four issues annually
Publication Programme: 2020. Vol. 68.
Indexing and Abstracting Services:

  • Biological Abstracts

     

  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture, Biology and Environmental Sciences
  • Elsevier Science Navigator
  • Focus On: Veterinary Science and Medicine
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Subscribers can access the electronic version of every printed article.

Senior editors

Editor(s)-in-Chief: Benkő, Mária

Managing Editor(s): Székely, András

Editorial Board

      Dénes, Béla
      Eszterbauer, Edit
      Fébel, Hedvig
      Fodor, László
      Harrach, Balázs
      Andras Komaromy (USA)
      Peter Massanyi (Slovak Republic)
      Nagy, Béla
      Németh, Tibor
      Neogrády, Zsuzsanna
      Kurt Pfister (Germany)
      Solti, László
      Szabó, József
      Vajdovich, Péter
      Varga, János
      Štefan, Vilĉek (Slovak Republic)
      Vörös, Károly
      Herbert Weissenböck (Austria)
      Zsarnovszky, Attila

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793