View More View Less
  • 1 Szent István University, Páter K. u. 1, H-2103 Gödöllő, Hungary
  • | 2 Hungarian Academy of Sciences – Kaposvár University ‘MTA-KE Mycotoxins in the Food Chain’ Research Group, Kaposvár, Hungary
  • | 3 Szent István University, Gödöllő, Hungary
Open access

Short-term (48-hour) effects of 3.74/1.26 mg kg−1 T-2/HT-2 toxin or 16.12 mg kg−1 DON in feed were investigated in the liver of three-week-old cockerels (body weight: 749.60 ± 90.98 g). Markers of lipid peroxidation showed no significant changes. At hour 24, glutathione content in the T-2/HT-2 toxin group was significantly higher than in the control. Glutathione peroxidase activity was significantly higher than the control at hour 24 in the T-2/H-2 toxin group and at hour 48 in the DON group. In the DON group, expression of the glutathione peroxidase 4 gene (GPX4) was significantly lower than in the control at hours 12 and 14, and higher at hour 48. Expression of the glutathione reductase gene (GSR) was significantly lower than in the control at hour 12 in the T-2/HT-2 toxin group, and at hours 12, 24 and 48 in the DON group. However, at hour 36 higher GSR expression was measured in the DON group. Due to the effect of both trichothecenes, expression of the glutathione synthetase gene (GSS) was significantly lower than in the control at hours 24 and 48. In conclusion, T-2/HT-2 toxin and DON had a moderate short-term effect on free radical formation. T-2/HT-2 toxin induced more pronounced activation of the glutathione redox system than did DON.

  • 2006/576/EC (2006): Commission Recommendation on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding.

  • 2013/165/EU (2013): Commission Recommendation on the presence of T-2 and HT-2 toxin in cereals and cereal products.

  • AOAC (1984): Official Methods of Analysis. 14th edition. Method 28.054. Association of Official Analytical Chemists, Arlington.

  • Awad, W. A., Ghareeb, K., Böhm, J., Razzazzi, E. and Zentek, J. (2008): The impact of Fusarium toxin deoxynivalenol (DON) on poultry. Int. J. Poult. Sci. 7, 827842.

    • Search Google Scholar
    • Export Citation
  • Awad, W. A., Hess, M., Twaruzek, M., Grajewski, J., Kosicki, R., Böhm, J. and Zentek, J. (2011 a): The impact of the Fusarium mycotoxin deoxynivalenol on the health and performance of broiler chickens. Int. J. Mol. Sci. 12, 79968012.

    • Search Google Scholar
    • Export Citation
  • Awad, W. A., Vahjen, W., Aschenbach, J. R. and Zentek, J. (2011 b): A diet naturally contaminated with the Fusarium mycotoxin deoxynivalenol (DON) downregulates gene expression of glucose transporters in the intestine of broiler chickens. Livestock Sci. 140, 7279.

    • Search Google Scholar
    • Export Citation
  • Awad, W. A., Ghareeb, K., Dadak, A., Hess, H. and Böhm, J. (2014): Single and combined effects of deoxynivalenol mycotoxin and a microbial feed additive on lymphocyte DNA damage and oxidative stress in broiler chickens. PLoS ONE 9, e88028. doi: 10.371/journal. pone.0088028

    • Search Google Scholar
    • Export Citation
  • Balogh, K., Bócsai, A., Pelyhe, Cs., Zándoki, E., Erdélyi, M., Szabó-Fodor, J. and Mézes, M. (2015): Effects of long-term feeding of graded levels of T-2 toxin-contaminated diets on performance, some lipid peroxide and glutathione redox status parameters of broiler chickens J. Poult. Sci. 52, 176182.

    • Search Google Scholar
    • Export Citation
  • Binder, E. M., Tan, L. M., Chin, L. J., Handl, J. and Richard, J. (2007): Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Anim. Feed Sci. Technol. 137, 265282.

    • Search Google Scholar
    • Export Citation
  • Botsoglou, N. A., Fletouris, D. J., Papageorgiou, G. E., Vassilopoulos, V. N., Mantis, A. J. and Trakatellis, A. G. (1994): Rapid, sensitive and specific thiobarbituric acid method for measuring lipid peroxidation in animal tissue, food and feedstuff samples. J. Agric. Food Chem. 42, 19311937.

    • Search Google Scholar
    • Export Citation
  • Dänicke, S., Gareis, M. and Bauer, J. (2001): Orientation values for critical concentrations of deoxynivalenol and zearalenone in diets for pigs, ruminants and gallinaceous poultry. Proc. Soc. Nutr. Physiol. 10, 171174.

    • Search Google Scholar
    • Export Citation
  • Eriksen, G. S. and Pettersson, H. (2004): Toxicological evaluation of trichothecenes in animal feed. Anim. Feed Sci. Technol. 114, 205239.

    • Search Google Scholar
    • Export Citation
  • Fodor, J., Németh, M., Kametler, L., Pósa, R., Kovács, M. and Horn, P. (2006): Novel methods of Fusarium toxins’ production for toxicological experiments. Acta Agraria Kaposváriensis 10, 277285.

    • Search Google Scholar
    • Export Citation
  • Frankic, T., Pajk, T., Rezar, V., Levart, A. and Salobir, J. (2006): The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. Food Chem. Toxicol. 44, 18381844.

    • Search Google Scholar
    • Export Citation
  • Gouze, M. E., Laffitte, J., Dedieu, G., Galinier, A., Thouvenot, J. P., Oswald, I. P. and Galtier, P. (2005): Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice. Cell Mol. Biol. 51 (Suppl.), OL809OL817.

    • Search Google Scholar
    • Export Citation
  • Grabarevic, Z., Nemanic, A., Jagic, V., Tisljar, M., Artukovic, B., Dzaja, P., Culjak, K. and Rinck, I. (1992): Subacute toxicity of T-2 toxin and DAS in broiler chicks. Vet. Arhiv 62, 317324.

    • Search Google Scholar
    • Export Citation
  • Greiner, B. and Applegate, T. J. (2013): Modulation of intestinal functions following mycotoxin ingestion: Meta-analysis of published experiments in animals. Toxins 5, 396430.

    • Search Google Scholar
    • Export Citation
  • Guerre, P., Eeckhoutte, C., Burgat, V. and Galtier, P. (2000): The effects of T-2 toxin exposure on liver drug metabolising enzymes in rabbit. Food Addit. Contam. 12, 10191026.

    • Search Google Scholar
    • Export Citation
  • Hoechler, D. and Marquardt, R. R. (1996): Influence of vitamins E and C on the toxic effects of ochratoxin A and T-2 toxin in chicks. Poult. Sci. 75, 15081515.

    • Search Google Scholar
    • Export Citation
  • Hungarian Feed Code (2004): Nutrient requirements of broiler chicken. Volume II [in Hungarian]. OMMI, Budapest. pp. 6567.

  • Konjevi, D., Sreboan, E., Gudan, A., Lojki, I., Severin, K. and Sokolovi, M. (2004): A pathological condition possibly caused by spontaneous trichotecene poisoning in Brahma poultry: first report. Avian Pathol. 33, 377380.

    • Search Google Scholar
    • Export Citation
  • Lawrence, R. A. and Burk, R. F. (1976): Glutathione peroxidase activity in selenium deficient rat liver. Biochem. Biophys. Res. Commun. 71, 952956.

    • Search Google Scholar
    • Export Citation
  • Livak, K. J. and Schmittgen, T. D. (2001): Analysis of relative gene expression data using realtime quantitative PCR and the 2 [-Delta Delta C (T)] method. Methods 25, 402408.

    • Search Google Scholar
    • Export Citation
  • Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265275.

    • Search Google Scholar
    • Export Citation
  • Mézes, M., Barta, M. and Nagy, G. (1998): Comparative investigation on the effect of T-2 mycotoxin on lipid peroxidation and antioxidant status in different poultry species. Res. Vet. Sci. 66, 1923.

    • Search Google Scholar
    • Export Citation
  • Pelyhe, Cs., Kövesi, B., Zándoki, E., Kovács, B., Szabó-Fodor, J., Mézes, M. and Balogh, K. (2016): Short-term effects of T-2 toxin or deoxynivalenol on lipid peroxidation and the glutathione system in common carp. Acta Vet. Hung. 64, 449466.

    • Search Google Scholar
    • Export Citation
  • Peng, Z., Chen, L., Nüssler, A. K., Liu, L. and Yang, W. (2017): Current sights for mechanisms of deoxynivalenol-induced hepatotoxicity and prospective views for future scientific research: A mini review. J. Appl. Toxicol. 37, 518529.

    • Search Google Scholar
    • Export Citation
  • Pussemier, L., Piérard, J. Y., Anselme, M., Tangni, E. K., Motte, J. C. and Larondelle, Y. (2006): Development and application of analytical methods for the determination of mycotoxins in organic and conventional wheat. Food Addit. Contam. 23, 12081218.

    • Search Google Scholar
    • Export Citation
  • Rezar, V., Frankic, T., Nara, M., Levart, A. and Salobir, J. (2007): Dose dependent effects of T-2 toxin on performance, lipid peroxidation, and genotoxicity in broiler chicken. Poult. Sci. 86, 11551160.

    • Search Google Scholar
    • Export Citation
  • Sedlak, J. and Lindsay, R. H. C. (1968): Estimation of total, protein bound and non-protein sulfhyryl groups in tissue with Ellmann’s reagent. Anal. Biochem. 25, 192205.

    • Search Google Scholar
    • Export Citation
  • Sehata, S., Kiyosawa, N., Atsumi, F., Ito, K., Yamoto, T., Teranishi, M., Uetsuka, K., Nakayama, H. and Doi, K. (2005): Microarray analysis of T-2 toxin-induced liver, placenta and fetal liver lesions in pregnant rats. Exp. Toxicol. Pathol. 57, 1528.

    • Search Google Scholar
    • Export Citation
  • Shelly, C. and Lu, M. D. (2013): Glutathione synthesis. Biochim. Biophys. Acta 1830, 31433153.

  • Trebstein, A., Seefelder, W., Lauber, U. and Humpf, H. U. (2008): Determination of T-2 and HT-2 toxins in cereals including oats after immunoaffinity cleanup by liquid chromatography and fluorescence detection. J. Agric. Food Chem. 56, 49684975.

    • Search Google Scholar
    • Export Citation
  • Ványi, A., Sályi, G., Majoros, G., Glávits, R., Sándor, G. and Bagó, Gy. (1989): Investigations on the connection between T-2 fusariotoxin and monensin in coccidian infected boiler chicken [in Hungarian, with English abstract). Magy. Allatorvosok 44, 293298.

    • Search Google Scholar
    • Export Citation
  • Yang, L., Yu, Z., Hou, J., Deng, Y., Zhou, Z., Zhao, Z. and Cui, J. (2016): Toxicity and oxidative stress induced by T-2 toxin and HT-2 toxin in broilers and broiler hepatocytes Food Chem. Toxicol. 87, 128137.

    • Search Google Scholar
    • Export Citation
  • Zimniak, L., Awasthi, S., Srivastava, S. K. and Zimniak, P. (1997): Increased resistance to oxidative stress in transfected cultured cells overexpressing glutathione S-transferase mGSTA4- 4. Toxicol. Appl. Pharmacol. 143, 221229.

    • Search Google Scholar
    • Export Citation

Author information is available in PDF.
Please, download the file from HERE.

The manuscript preparation instructions is available in PDF.
Please, download the file from HERE.

Senior editors

Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture, Biology and Environmental Sciences
  • Elsevier Science Navigator
  • Focus On: Veterinary Science and Medicine
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
sumbission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

Acta Veterinaria Hungarica
Publication Model Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article
Printed Color Illustrations 40 EUR (or 10 000 HUF) + VAT / piece
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2021 Online subsscription: 696 EUR / 872 USD
Print + online subscription: 804 EUR / 1004 USD
Subscription fee 2022 Online subsscription: 710 EUR / 892 USD
Print + online subscription: 824 EUR / 1028 USD
Subscription Information Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Publication
Programme
2020 Volume 68
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 0 11 8
May 2021 0 8 10
Jun 2021 0 13 8
Jul 2021 0 4 5
Aug 2021 0 19 2
Sep 2021 0 10 7
Oct 2021 0 7 4