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  • 1 Department of Animal Health (AGR-149) , 14014, Córdoba, Spain
  • 2 Department of Pathological Anatomy, Córdoba, Spain
  • 3 Veterinary Consultant, Córdoba, 14071, Spain
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This paper describes the first documented outbreak of haemorrhagic septicaemia (HS) caused by Pasteurella multocida type B in cattle in Spain. This acute, highly fatal septicaemia causes major economic losses in cattle and buffaloes in many areas of Asia and Africa. In other species and in European countries it is an infrequently reported disease. Acute septicaemic pasteurellosis occurred in a free-range farm of 150 cattle and 70 beef calves in Southern Spain. Twenty-one calves and one cow were affected, of which three calves and the adult cow died. Postmortem examination revealed characteristic oedema in the ventral area of the neck and the brisket region, and widespread haemorrhages in all organs. Pure cultures of P. multocida were obtained from all tissues and organs studied. The aetiological agent was further confirmed by molecular and biochemical analysis as P. multocida capsular type B, biovar 3. Although the source of infection could not be determined, wildlife may play an important role. The use of tulathromycin in the initial stage of the disease might be related to the low morbidity and mortality of this outbreak. After using an autogenous vaccine no more cases of HS were observed.

  • Blackall, P. J., Pahoff, J. L. and Bowles, R. (1997): Phenotypic characterisation of Pasteurella multocida isolates from Australian pigs. Vet. Microbiol. 57, 355360.

    • Search Google Scholar
    • Export Citation
  • Borge, C., Barranco, I., Márquez del Cid, J. M., Rodríguez-Guerra, M. A., Carbonero, A., Carrasco, L. and Perea, A. (2011): Outbreak of acute septicaemia by Pasteurella multocida type B in pigs reared in extensive system in Spain. In: Proceedings of the 3rd European Symposium of Porcine Health Management (ESPHM). Espoo, Finland. p 127.

    • Search Google Scholar
    • Export Citation
  • Cardoso-Toset, F., Gomez-Laguna, J., Callejo, M., Vela, A. I., Carrasco, L., Fernandez-Garayzabal, J. F., Maldonado, A. and Luque, I. (2013): Septicaemic pasteurellosis in free-range pigs associated with an unusual biovar 13 of Pasteurella multocida. Vet. Microbiol. 167, 690694.

    • Search Google Scholar
    • Export Citation
  • De Alwis, M. C. (1992): Haemorrhagic septicaemia – A general review. Br. Vet. J. 148, 99112.

  • Eriksen, L., Aalbaek, B., Leifsson, P. S., Basse, A., Christiansen, T., Eriksen, E. and Rimler, R. B. (1999): Hemorrhagic septicemia in fallow deer (Dama dama) caused by Pasteurella multocida multocida. J. Zoo Wildl. Med. 30, 285292.

    • Search Google Scholar
    • Export Citation
  • Gamage, L. N. A., Wijewardana, T. G., Bastiansz, H. L. G. and Vipulasiri, A. A. (1995): An outbreak of acute pasteurellosis in swine caused by serotype B:2 in Sri Lanka. Sri Lanka Vet. J. 42, 1519.

    • Search Google Scholar
    • Export Citation
  • Harper, M., Boyce, J. D. and Adler, B. (2006): Pasteurella multocida pathogenesis: 125 years after Pasteur. FEMS Microbiol. Lett. 265, 110.

    • Search Google Scholar
    • Export Citation
  • Magyar, T., Ujvári, B., Szeredi, L., Virsinger, N., Albert, E., Német, Z., Csuka, E. and Biksi, I. (2017): Re-emergence of bovine haemorrhagic septicaemia in Hungary. Acta Vet. Hung. 65, 4149.

    • Search Google Scholar
    • Export Citation
  • Mutters, R., Ihm, P., Pohl, S., Frederiksen, W. and Mannheim, W. (1985): Reclassification of the genus Pasteurella Trevisan 1887 on the basis of deoxyribonucleic acid homology, with proposals for the new species Pasteurella dagmatis, Pasteurella canis, Pasteurella stomatis, Pasteurella anatis and Pasteurella langaa. Int. J. Syst. Bacteriol. 35, 309322.

    • Search Google Scholar
    • Export Citation
  • Risco, D., Fernández-Llario, P., Cuesta, J. M., García-Jiménez, W. L., Gil, M., Gonçalves, P., Martínez, R., Gómez, L., García, A., Rey, J., Hermoso de Mendoza, M. and Hermoso de Mendoza, J. H. (2013): Fatal outbreak of systemic pasteurellosis in a wild boar (Sus scrofa) population from southwest Spain. J. Vet. Diagn. Invest. 25, 791794.

    • Search Google Scholar
    • Export Citation
  • Shivachandra, S. B., Viswas, K. N. and Kumar, A. A. (2011): A review of hemorrhagic septicemia in cattle and buffalo. Anim. Health Res. Rev./Conference of Research Workers in Animal Diseases 12, 6782.

    • Search Google Scholar
    • Export Citation
  • Soike, D., Schulze, C., Kutzer, P., Ewert, B., van der Grinten, E., Schliephake, A., Ewers, C., Bethe, A. and Rau, J. (2012): Acute pasteurellosis in fallow deer, cattle and pigs in a region of Eastern Germany. Berl. Munch. Tierarztl. Wschr. 125, 122128.

    • Search Google Scholar
    • Export Citation
  • Townsend, K. M., Boyce, J. D., Chung, J. Y., Frost, A. J. and Adler, B. (2001): Genetic organization of Pasteurella multocida cap loci and development of a multiplex capsular PCR typing system. J. Clin. Microbiol. 39, 924929.

    • Search Google Scholar
    • Export Citation
  • Townsend, K. M., Frost, A. J., Lee, C. W., Papadimitriou, J. M. and Dawkins, H. J. S. (1998a): Development of PCR assays for species- and type-specific identification of Pasteurella multocida isolates. J. Clin. Microbiol. 36, 10961100.

    • Search Google Scholar
    • Export Citation
  • Townsend, K. M., O'Boyle, D., Phan, T. T., Hanh, T. X., Wijewardana, T. G., Wilkie, I., Trung, N. T. and Frost, A. J. (1998b): Acute septicaemic pasteurellosis in Vietnamese pigs. Vet. Microbiol. 63, 205215.

    • Search Google Scholar
    • Export Citation
  • Ujvári, B., Makrai, L. and Magyar, T. (2018): Characterisation of a multiresistant Pasteurella multocida strain isolated from cattle. Acta Vet. Hung. 66, 1219.

    • Search Google Scholar
    • Export Citation
  • Ujvári, B., Szeredi, L., Pertl, L., Tóth, G., Erdélyi, K., Jánosi, S., Molnár, T. and Magyar, T. (2015): First detection of Pasteurella multocida type B:2 in Hungary associated with systemic pasteurellosis in backyard pigs. Acta Vet. Hung. 63, 141156.

    • Search Google Scholar
    • Export Citation
  • Verma, N. D. (1988): Pasteurella multocida B:2 in haemorrhagic septicaemia outbreak in pigs in India. Vet. Rec. 123, 63.

  • Volker, I., Kehler, W., Hewicker-Trautwein, M., Seehusen, F., Verspohl, J., Bilk, S. and Baumgartner, W. (2014): Re-emergence of haemorrhagic septicaemia in ungulates in Lower-Saxony in Germany. Vet. Rec. 175, 460.

    • Search Google Scholar
    • Export Citation

  • Impact Factor (2018): 1.059
  • Veterinary (miscellaneous) SJR Quartile Score (2018): Q2
  • Scimago Journal Rank (2018): 0.517
  • SJR Hirsch-Index (2018): 30

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Senior editors

Editor(s)-in-Chief: Benkő, Mária

Managing Editor(s): Székely, András

Editorial Board

      Dénes, Béla
      Eszterbauer, Edit
      Fébel, Hedvig
      Fodor, László
      Harrach, Balázs
      Andras Komaromy (USA)
      Peter Massanyi (Slovak Republic)
      Nagy, Béla
      Németh, Tibor
      Neogrády, Zsuzsanna
      Kurt Pfister (Germany)
      Solti, László
      Szabó, József
      Vajdovich, Péter
      Varga, János
      Štefan, Vilĉek (Slovak Republic)
      Vörös, Károly
      Herbert Weissenböck (Austria)
      Zsarnovszky, Attila

Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793

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