View More View Less
  • 1 Department of Zoology University of Colombo Colombo-03, Sri Lanka
  • | 2 Department of Chemistry, University of Colombo Colombo-03, Sri Lanka
  • | 3 Department of Chemistry, University of Colombo Colombo-03, Sri Lanka
  • | 4 Department of Chemistry, University of Colombo Colombo-03, Sri Lanka
  • | 5 Department of Zoology University of Colombo Colombo-03, Sri Lanka
Restricted access

The aim of this study was to examine the antinociceptive potential of leaves of Ixoracoccinea (family: Rubeaceae). One of four doses (500, 750, 1000 or 1500 mg/kg, n=8/dose) of aqueous leaf extract (ALE) or 1 ml of distilled water was orally administered to male rats and antinociceptive activity was ascertained using three models of nociception (tail flick, hot plate and formalin tests). The results showed that ALE possesses considerable antinociceptive activity (when evaluated in hot plate and formalin test but not in tail flick test). The antinociceptive activity of the ALE had a rapid onset (within 1 h) and a fairly long duration of action (up to 5 h) with a peak effect at 3 h. Further, the antinociceptive activity was dose-dependent and was not associated with harmful side-effects or toxicity even following subchronic administration. The antinociceptive action was mediated centrally at the supraspinal level mainly via dopaminergic mechanism. In addition, it is likely that antioxidant activity of the ALE could have played an auxiliary role in inducing antinociception. Dopaminergic and antioxidative activities of ALE could arise, respectively, from its quaternary base alkaloid and flavonoid constituents.

  • Farsam, H., Amanlou, M., Dehpour, A. Z., Jahaniani, F. (2000) Anti-inflammatory and analgesic activity of Biebersteinia multifida DC. root extract. J. Ethnopharmaco. 71, 443-447.

    'Anti-inflammatory and analgesic activity of Biebersteinia multifida DC. root extract ' () 71 J. Ethnopharmaco : 443 -447.

    • Search Google Scholar
  • File, S. E., Wardill, A. (1975) Validity of head dipping as a measure of exploration in modified hole-board. Psychopharmacologia 44, 53-57.

    'Validity of head dipping as a measure of exploration in modified hole-board ' () 44 Psychopharmacologia : 53 -57.

    • Search Google Scholar
  • Ghai, C. L. (1993) A Textbook of Practical Physiology. Jaypee Brothers Medical Publishers Ltd., New Delhi, pp. 119-202.

    A Textbook of Practical Physiology , () 119 -202.

  • Halliwell, B. (1994) Free radical antioxidants in human disease: Curiosity, cause or consequence. Lancet 344, 721-724.

    'Free radical antioxidants in human disease: Curiosity, cause or consequence ' () 344 Lancet : 721 -724.

    • Search Google Scholar
  • Latha, P. G., Panikkar, K. R. (1999) Modulatory effects of Ixora coccinea flower on cyclophosphamide-induced toxicity in mice. Phytotherapy Res. 13, 517-520.

    'Modulatory effects of Ixora coccinea flower on cyclophosphamide-induced toxicity in mice ' () 13 Phytotherapy Res : 517 -520.

    • Search Google Scholar
  • Luedtke, R. R., Freeman, R. A., Volk, M., Arfan, M., Reinecke, M. G. (2003) Pharmacological survey of medicinal plants for activity at dopamine receptor subtypes. II. Screen for binding activity at the D1 and D2 dopamine receptor subtypes. Pharmaceutical Biol. 41, 45-58.

    'Pharmacological survey of medicinal plants for activity at dopamine receptor subtypes. II. Screen for binding activity at the D1 and D2 dopamine receptor subtypes ' () 41 Pharmaceutical Biol : 45 -58.

    • Search Google Scholar
  • Dharmasiri, M. G., Ratnasooriya, W. D., Thabrew, M. I. (2003) Water extract of leaves and stems of pre-flowering but not flowering plants of Anisomeles indica possesses analgesic and antihyperalgesic activity in rats. Pharm. Biol. 41, 37-44.

    'Water extract of leaves and stems of pre-flowering but not flowering plants of Anisomeles indica possesses analgesic and antihyperalgesic activity in rats ' () 41 Pharm. Biol : 37 -44.

    • Search Google Scholar
  • Dorman, H. S. D., Deans, S. G., Noble, R. C. (1995) Evaluation in vitro of plant essential oils as natural antioxidants. J. Essent. Oil Res. 7, 645-651.

    'Evaluation in vitro of plant essential oils as natural antioxidants ' () 7 J. Essent. Oil Res : 645 -651.

    • Search Google Scholar
  • Farnsworth, N. R. (1998) Phytochemical Screening. Chicago College of Pharmacy, University of Illinois, pp. 32-65.

    Phytochemical Screening , () 32 -65.

  • Hull, E. M., Du, J., Lorrain, D. S., Matuszewich, L. (1997) Testosteron, preoptic dopamine, and copulation in male rats. Brain Res. Bull. 44, 327-333.

    'Testosteron, preoptic dopamine, and copulation in male rats ' () 44 Brain Res. Bull : 327 -333.

    • Search Google Scholar
  • Jayaweera, D. M. A. (1982) Medicinal Plants Used in Ceylon, part IV. National Science Council of Sri Lanka, Colombo, Sri Lanka.

    Medicinal Plants Used in Ceylon part IV , ().

  • Kaseda, S., Nomoto, M., Iwata, S. (1999) Effect of selegiline on dopamine concentration in the striatum of a primate. Brain Res. 815, 44-50.

    'Effect of selegiline on dopamine concentration in the striatum of a primate ' () 815 Brain Res : 44 -50.

    • Search Google Scholar
  • Deraniyagala, S. A., Ratnasooriya, W. D., Goonesekera, C. L. (2003) Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats. J. Ethnopharmacol. 2846, 1-6.

    'Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats ' () 2846 J. Ethnopharmacol : 1 -6.

    • Search Google Scholar
  • Latha, P. G., Nayar, M. N. S., Sing, O. V., George, K. R., Panikkar, K. R., Pushpangadan, P. (2001) Isolation of antigenotoxic ursolic acid from Ixora coccinea flowers. Actual Biol. 23, 21-24.

    'Isolation of antigenotoxic ursolic acid from Ixora coccinea flowers ' () 23 Actual Biol : 21 -24.

    • Search Google Scholar
  • Latha, P. G., Panikkar, K. R. (1998) Cytotoxic and antitumor principles from Ixora coccinea flowers. Cancer Lett. 130, 197-202.

    'Cytotoxic and antitumor principles from Ixora coccinea flowers ' () 130 Cancer Lett : 197 -202.

    • Search Google Scholar
  • Latha, P. G., Panikkar, K. R. (2001) Chemoprotective effect of Ixora coccinea L. flowers on cisplatin induced toxicity in mice. Phytotherapy Res. 15, 364-366.

    'Chemoprotective effect of Ixora coccinea L. flowers on cisplatin induced toxicity in mice ' () 15 Phytotherapy Res : 364 -366.

    • Search Google Scholar
  • Ratnasooriya, W. D., Galhena, G., Liyanage, S. S. P., Jayakody, J. R. A. C., Ediriwcera, E. R. H. S. S. (2003) Analgesic and antihyperalgesic activities of decoction of Sri Lankan Scoparia dulcis in rats. J. Tropical Med. Plants (in press).

  • de Campos, R. O. P., Santos, A. R. S., Vaz, Z. R., Pinheiro, T. R., Pizzolatti, M. G., Filho, V. C., Monache, F. D., Yunes, R. A., Calixto, J. B. (1997) Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias. Life Sci. 61, 1619-1630.

    'Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias ' () 61 Life Sci : 1619 -1630.

    • Search Google Scholar
  • Reena, Z., Sudhakaran, N., Velayudha, C. R., Panicker, P. (1994) Anti-inflammatory and anti-mitotic activities of lupeol isolated from the leaves of Ixora coccinea. Linn. Indian J. Pharm. Sci. 56, 129-132.

    'Anti-inflammatory and anti-mitotic activities of lupeol isolated from the leaves of Ixora coccinea ' () 56 Linn. Indian J. Pharm. Sci : 129 -132.

    • Search Google Scholar
  • Richardson, J. D., Aanonsen, L., Hargreaves, K. M. (1998) Antihyperalgesic effects of spinal connabinoids. European J. Pharmacol. 345, 145-153.

    'Antihyperalgesic effects of spinal connabinoids ' () 345 European J. Pharmacol : 145 -153.

    • Search Google Scholar
  • Sasidharan, V. K. (1997) Search for antibacterial and antifungal activity of some plants of Kerala. Acta Pharm. 47, 47-51.

    'Search for antibacterial and antifungal activity of some plants of Kerala ' () 47 Acta Pharm : 47 -51.

    • Search Google Scholar
  • Miguel, O. G., Calixto, J. B., Santos, A. R. S., Messana, I., Ferrari, F., Filho, V. C., Pizzolatti, M. G., Yunes, R. A. (1996) Chemical and preliminary analgesic evaluation of Geraniin and Furosin isolated from Phyllanthus sellowianus. Planta Medica 62, 97-192.

    'Chemical and preliminary analgesic evaluation of Geraniin and Furosin isolated from Phyllanthus sellowianus ' () 62 Planta Medica : 97 -192.

    • Search Google Scholar
  • Rang, H. P., Dale, M. M., Ritter, J. M. (1995) Pharmacology. Churchill, Livingston, London.

    Pharmacology , ().

  • Ratnasooriya, W. D., Dharmasiri, M. G. (1999) Water extracts of Psychotria sarmentosa has analgesic and antihyperalgesic activity in rats. Med. Sci. Res. 27, 715-718.

    'Water extracts of Psychotria sarmentosa has analgesic and antihyperalgesic activity in rats ' () 27 Med. Sci. Res : 715 -718.

    • Search Google Scholar
  • Ratnasooriya, W. D., Deraniyagala, S. A., Bathige, S. D. N. K., Galhena, G., Liyanage, S. S. P., Jayakody, J. R. A. C. (2004) Anti-inflammatory activity of the aqueous leaf extract of Ixora coccinea in rats. J. Pharm. Biol. (in press).

  • Tjolsen, A., Berge, O. G., Hunskaar, S., Rosland, J. H., Hole, K. (1992) The formalin test: an evaluation of the method. Pain 51, 5-17.

    'The formalin test: an evaluation of the method ' () 51 Pain : 5 -17.

  • Wong, C. H., Day, P., Yarmush, J., Wu, W., Zbuzek, U. K. (1994) Nifedipine-induced analgesic after epidural injections in rats. Anesthesia Analgesia 79, 303-306.

    'Nifedipine-induced analgesic after epidural injections in rats ' () 79 Anesthesia Analgesia : 303 -306.

    • Search Google Scholar
  • Anonymous, British National Formulary 2000. The British Medical Association and the Royal Pharmaceutical Society of Great Britain, London.

    Anonymous, British National Formulary 2000 , ().

  • Bowers, M. B., Van Woert, M., Davis, L. (1971) Sexual behavior during L-dopa treatment for Parkinsonism. Am. J. Psychiatry 127, 1691-1693.

    127 1691 1693

Editorial Board

      Csányi, Vilmos (Göd)
      Dudits, Dénes (Szeged)
      Falus, András (Budapest)
      Fischer, Ernő (Pécs)
      Gábriel, Róbert (Pécs)
      Gulya, Károly (Szeged)
      Gulyás, Balázs (Stockholm)
      Hajós, Ferenc (Budapest)
      Hámori, József (Budapest)
      Heszky, László (Gödöllő)
      Hideg, Éva (Szeged)
      E. Ito (Sanuki)
      Janda, Tibor (Martonvásár)
      Kavanaugh, Michael P. (Missoula)
      Kása, Péter (Szeged)
      Klein, Éva (Stockholm)
      Kovács, János (Budapest)
      Brigitte Mauch-Mani (Neuchâtel)
      Nässel, Dick R. (Stockholm)
      Nemcsók, János (Szeged)
      Péczely, Péter (Gödöllő)
      Roberts, D. F. (Newcastle-upon-Tyne)
      Sakharov, Dimitri A. (Moscow)
      Singh, Meharvan (Fort Worth)
      Sipiczky, Mátyás (Debrecen)
      Szeberényi, József (Pécs)
      Székely, György (Debrecen)
      Tari, Irma (Szeged)
      Vágvölgyi, Csaba (Szeged),
      L. Zaborszky (Newark)

 

Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture
  • Biology and Environmental Sciences
  • Elsevier BIOBASE
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)