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  • 1 Department of Pharmacognosy, University of Pécs, Rókus u. 2., Pécs, H-7624, Hungary
  • | 2 Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre u. 9., Budapest H-1092, Hungary
  • | 3 Institutional Excellence Program, Natural Bioactive Compounds Group, Eötvös Loránd University, Kazinczy u. 23–27., Budapest H-1075, Hungary
  • | 4 Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Szigeti út 12, Pécs H-7624, Hungary
Open access

Introduction

Several Aristolochia species were used as medicinal herb across Europe and in recent years, their antimicrobial activity has also been investigated.

Materials and methods

In this study, A. clematitis was selected to evaluate the aristolochic acids I and II (AA I and AA II) concentrations and the antimicrobial activity of methanol, hexane, butanol, and ethyl acetate extracts of the root, stem, leaf, root, and fruit. AA I and AA II contents were measured by a validated high-performance liquid chromatography–ultraviolet method.

Results

Each fraction of the plant contained AA I and AA II and the root was found to have the highest contents of AA I (1.09%) and AA II (0.7454%). The minimum inhibitory concentrations of all extracts were determined by standard microdilution method. The fruit’s extracts showed the most efficient antimicrobial effect against both methicillin sensitive and resistant Staphylococcus aureus strains.

Conclusion

Correlation between the AA I and AA II concentrations and the antimicrobial effect was not found.

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Biologia Futura
Language English
Size A4
Year of
Foundation
2019 (1950)
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia  
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2676-8615 (Print)
ISSN 2676-8607 (Online)